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Microscopy imaging plays a vital role in understanding many biological processes in development and disease. The recent advances in automation of microscopes and development of methods and markers for live cell imaging has led to rapid…

Computer Vision and Pattern Recognition · Computer Science 2017-05-10 Saad Ullah Akram , Juho Kannala , Lauri Eklund , Janne Heikkilä

Due to the advent of new mobile devices and tracking sensors in recent years, huge amounts of data are being produced every day. Therefore, novel methodologies need to emerge that dive through this vast sea of information and generate…

Computer Vision and Pattern Recognition · Computer Science 2022-05-31 Ioannis Kontopoulos , Antonios Makris , Konstantinos Tserpes , Vania Bogorny

We present a novel graph neural network (GNN) approach for cell tracking in high-throughput microscopy videos. By modeling the entire time-lapse sequence as a direct graph where cell instances are represented by its nodes and their…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Tal Ben-Haim , Tammy Riklin Raviv

The accurate tracking of live cells using video microscopy recordings remains a challenging task for popular state-of-the-art image processing based object tracking methods. In recent years, several existing and new applications have…

Image and Video Processing · Electrical Eng. & Systems 2025-02-03 Gergely Szabó , Paolo Bonaiuti , Andrea Ciliberto , András Horváth

Recent Large Vision-Language Models (LVLMs) demonstrate remarkable capabilities in image understanding and natural language generation. However, current approaches focus predominantly on global image understanding, struggling to simulate…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Fan Yang , Shurong Zheng , Hongyin Zhao , Yufei Zhan , Xin Li , Yousong Zhu , Chaoyang Zhao Ming Tang , Jinqiao Wang

Understanding the dynamic nature of biological systems is fundamental to deciphering cellular behavior, developmental processes, and disease progression. Single-cell RNA sequencing (scRNA-seq) has provided static snapshots of gene…

Quantitative Methods · Quantitative Biology 2025-05-02 Zhenyi Zhang , Yuhao Sun , Qiangwei Peng , Tiejun Li , Peijie Zhou

In visual exploration and analysis of data, determining how to select and transform the data for visualization is a challenge for data-unfamiliar or inexperienced users. Our main hypothesis is that for many data sets and common analysis…

Motivation: Networks underlie the generation and interpretation of many biological datasets: gene networks shed light on the regulatory structure of the genome, and cell networks can capture structure of the tumor micro-environment.…

Machine Learning · Statistics 2026-03-18 Bailey Andrew , Erica L. Harris , James A. Poulter , David R. Westhead , Luisa Cutillo

This paper presents a method for time-lapse 3D cell analysis. Specifically, we consider the problem of accurately localizing and quantitatively analyzing sub-cellular features, and for tracking individual cells from time-lapse 3D confocal…

Computer Vision and Pattern Recognition · Computer Science 2022-08-18 Jiaxiang Jiang , Amil Khan , S. Shailja , Samuel A. Belteton , Michael Goebel , Daniel B. Szymanski , B. S. Manjunath

Determining cell identities in imaging sequences is an important yet challenging task. The conventional method for cell identification is via cell tracking, which is complex and can be time-consuming. In this study, we propose an innovative…

Quantitative Methods · Quantitative Biology 2024-03-05 Baiyang Dai , Jiamin Yang , Hari Shroff , Patrick La Riviere

The rapid development of Convolutional Neural Networks (CNNs) in recent years has triggered significant breakthroughs in many machine learning (ML) applications. The ability to understand and compare various CNN models available is thus…

Machine Learning · Computer Science 2022-01-19 Xiwei Xuan , Xiaoyu Zhang , Oh-Hyun Kwon , Kwan-Liu Ma

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…

Genomics · Quantitative Biology 2024-12-09 Shuang Ge , Shuqing Sun , Huan Xu , Qiang Cheng , Zhixiang Ren

Advances in deep learning have greatly widened the scope of automatic computer vision algorithms and enable users to ask questions directly about the content in images and video. This paper explores the necessary steps towards a future…

Databases · Computer Science 2018-12-20 Sanjay Krishnan , Adam Dziedzic , Aaron J. Elmore

Vision-language models (VLMs) perform strongly on many multimodal benchmarks. However, the ability to follow complex visual paths -- a task that human observers typically find straightforward -- remains under-tested. We introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Clara Petrova , Zhuo Chen , Marin Soljačić

Many statistical learning models hold an assumption that the training data and the future unlabeled data are drawn from the same distribution. However, this assumption is difficult to fulfill in real-world scenarios and creates barriers in…

Human-Computer Interaction · Computer Science 2020-09-16 Yuxin Ma , Arlen Fan , Jingrui He , Arun Reddy Nelakurthi , Ross Maciejewski

There is a growing trend of applying machine learning methods to medical datasets in order to predict patients' future status. Although some of these methods achieve high performance, challenges still exist in comparing and evaluating…

Medical Physics · Physics 2020-03-25 Yiran Li , Takanori Fujiwara , Yong K. Choi , Katherine K. Kim , Kwan-Liu Ma

Retinal vessel segmentation serves as a critical prerequisite for automated diagnosis of retinal pathologies. While recent advances in Convolutional Neural Networks (CNNs) have demonstrated promising performance in this task, significant…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Zhanqiang Guo , Jianjiang Feng , Jie Zhou

The task of RNA design given a target structure aims to find a sequence that can fold into that structure. It is a computationally hard problem where some version(s) have been proven to be NP-hard. As a result, heuristic methods such as…

Biomolecules · Quantitative Biology 2024-12-13 Wei Yu Tang , Ning Dai , Tianshuo Zhou , David H. Mathews , Liang Huang

Single-cell sequencing has a significant role to explore biological processes such as embryonic development, cancer evolution, and cell differentiation. These biological properties can be presented by a two-dimensional scatter plot.…

Genomics · Quantitative Biology 2021-10-19 Ziyi Liu , Minghui Liao , Fulin luo , Bo Du