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Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex…

Biomolecules · Quantitative Biology 2021-02-02 Zichao Yan , William L. Hamilton , Mathieu Blanchette

A common network analysis task is comparison of two networks to identify unique characteristics in one network with respect to the other. For example, when comparing protein interaction networks derived from normal and cancer tissues, one…

Social and Information Networks · Computer Science 2020-08-18 Takanori Fujiwara , Jian Zhao , Francine Chen , Kwan-Liu Ma

A `trajectory' refers to a trace generated by a moving object in geographical spaces, usually represented by of a series of chronologically ordered points, where each point consists of a geo-spatial coordinate set and a timestamp. Rapid…

Machine Learning · Computer Science 2021-11-16 Seongjin Choi

Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we…

Genomics · Quantitative Biology 2024-04-17 Mahnoor N. Gondal , Saad Ur Rehman Shah , Arul M. Chinnaiyan , Marcin Cieslik

How a single fertilized cell gives rise to a complex array of specialized cell types in development is a central question in biology. The cells grow, divide, and acquire differentiated characteristics through poorly understood molecular…

Machine Learning · Computer Science 2025-03-26 Da Kuang , Guanwen Qiu , Junhyong Kim

The accurate retinal vessel segmentation (RVS) is of great significance to assist doctors in the diagnosis of ophthalmology diseases and other systemic diseases. Manually designing a valid neural network architecture for retinal vessel…

Image and Video Processing · Electrical Eng. & Systems 2020-03-19 Zhun Fan , Jiahong Wei , Guijie Zhu , Jiajie Mo , Wenji Li

Trajectory prediction of vehicles in city-scale road networks is of great importance to various location-based applications such as vehicle navigation, traffic management, and location-based recommendations. Existing methods typically…

Machine Learning · Computer Science 2021-12-16 Yuebing Liang , Zhan Zhao

Data visualisation is a key tool in data mining for understanding big datasets. Many visualisation methods have been proposed, including the well-regarded state-of-the-art method t-Distributed Stochastic Neighbour Embedding. However, the…

Neural and Evolutionary Computing · Computer Science 2020-01-29 Andrew Lensen , Bing Xue , Mengjie Zhang

Benchmark datasets play an important role in evaluating Natural Language Understanding (NLU) models. However, shortcuts -- unwanted biases in the benchmark datasets -- can damage the effectiveness of benchmark datasets in revealing models'…

Human-Computer Interaction · Computer Science 2023-01-16 Zhihua Jin , Xingbo Wang , Furui Cheng , Chunhui Sun , Qun Liu , Huamin Qu

Generative models, such as GANs and diffusion models, have been used to augment training sets and boost performances in different tasks. We focus on generative models for cell detection instead, i.e., locating and classifying cells in given…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Chen Li , Xiaoling Hu , Shahira Abousamra , Meilong Xu , Chao Chen

The study of complex many-body systems via analysis of the trajectories of the units that dynamically move and interact within them is a non-trivial task. The workflow for extracting meaningful information from the raw trajectory data is…

Materials Science · Physics 2025-10-31 Simone Martino , Matteo Becchi , Andrew Tarzia , Daniele Rapetti , Giovanni M. Pavan

Biological foundation models have shown strong performance in single-cell representation learning by applying transformer architectures directly to gene-expression matrices. However, these approaches predominantly operate in static settings…

Machine Learning · Computer Science 2026-05-28 Manuel Dileo , Andrea Sottoriva

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress…

We introduce a design study process model for medical visualization based on the analysis of existing medical visualization and visual analysis works, and our own interdisciplinary research experience. With a literature review of related…

Human-Computer Interaction · Computer Science 2025-12-25 Mengjie Fan , Liang Zhou

Vision-and-Language Navigation (VLN), where an agent follows instructions to reach a target destination, has recently seen significant advancements. In contrast to navigation in discrete environments with predefined trajectories, VLN in…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Guangzhao Dai , Jian Zhao , Yuantao Chen , Yusen Qin , Hao Zhao , Guosen Xie , Yazhou Yao , Xiangbo Shu , Xuelong Li

Many end-user evaluations of data visualization techniques have been run during the last decades. Their results are cornerstones to build efficient visualization systems. However, designing such an evaluation is always complex and…

Human-Computer Interaction · Computer Science 2020-04-20 L. Giovannangeli , R. Bourqui , R. Giot , D. Auber

The absence of a conventional association between the cell-cell cohabitation and its emergent dynamics into cliques during development has hindered our understanding of how cell populations proliferate, differentiate, and compete, i.e. the…

Machine Learning · Computer Science 2022-10-11 Baihan Lin

Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer…

Image and Video Processing · Electrical Eng. & Systems 2019-12-17 Wei Qiu , Jiaming Guo , Xiang Li , Mengjia Xu , Mo Zhang , Ning Guo , Quanzheng Li

The collection of large, complex datasets has become common across a wide variety of domains. Visual analytics tools increasingly play a key role in exploring and answering complex questions about these large datasets. However, many…

Human-Computer Interaction · Computer Science 2020-06-19 David Borland , Wenyuan Wang , Jonathan Zhang , Joshua Shrestha , David Gotz

A key step in the Bayesian workflow for model building is the graphical assessment of model predictions, whether these are drawn from the prior or posterior predictive distribution. The goal of these assessments is to identify whether the…

Methodology · Statistics 2025-03-04 Teemu Säilynoja , Andrew R. Johnson , Osvaldo A. Martin , Aki Vehtari
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