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Capturing the structure of a population and characterising contacts within the population are key to reliable projections of infectious disease. Two main elements of population structure -- contact heterogeneity and age -- have been…

Physics and Society · Physics 2025-03-17 Luke Murray Kearney , Emma L. Davis , Matt J. Keeling

As the interactions between people increases, the impending menace of COVID-19 outbreaks materialize, and there is an inclination to apply lockdowns. In this context, it is essential to have easy-to-use indicators for people to use as a…

Populations and Evolution · Quantitative Biology 2021-01-26 Joaquín Salas

This study proposes a nonhomogeneous birth--death model which captures the dynamics of a directly transmitted infectious disease. Our model accounts for an important aspect of observed epidemic data in which only symptomatic infecteds are…

Applications · Statistics 2016-09-09 Jan van den Broek , Hiroshi Nishiura

In this paper, we consider a compartmental SIRS epidemic model with asymptomatic infection and seasonal succession, which is a periodic discontinuous differential system. The basic reproduction number $\mathcal{R}_0$ is defined and valuated…

Dynamical Systems · Mathematics 2017-08-15 Yilei Tang , Dongmei Xiao , Weinian Zhang , Di Zhu

A random graph model with prescribed degree distribution and degree dependent edge weights is introduced. Each vertex is independently equipped with a random number of half-edges and each half-edge is assigned an integer valued weight…

Probability · Mathematics 2015-05-28 Tom Britton , Maria Deijfen , Fredrik Liljeros

Contact matrices have become a key ingredient of modern epidemic models. They account for the stratification of contacts for the age of individuals and, in some cases, the context of their interactions. However, age and context are not the…

Physics and Society · Physics 2023-07-03 Adriana Manna , Lorenzo Dall'Amico , Michele Tizzoni , Marton Karsai , Nicola Perra

The Markovian approach, which assumes exponentially distributed interinfection times, is dominant in epidemic modeling. However, this assumption is unrealistic as an individual's infectiousness depends on its viral load and varies over…

Populations and Evolution · Quantitative Biology 2023-08-02 Qihui Yang , Joan Saldaña , Caterina Scoglio

We propose a new modeling framework for evaluating the risk of disease transmission during a pandemic in small-scale settings driven by stochasticity in the arrival and service processes, i.e., congestion-prone confined-space service…

Probability · Mathematics 2021-03-26 Kang Kang , Sherwin Doroudi , Mohammad Delasay , Alexander Wickeham

It is essential to understand the dynamics of epidemics in the presence of coexisting pathogens. There are various phenomenon that can effect the dynamics. In this paper, we formulate a mathematical model using different assumptions to…

Populations and Evolution · Quantitative Biology 2021-11-02 S. Ghersheen , V. Kozlov , U. Wennergren

We study the problem of estimating the parameters (i.e., infection rate and recovery rate) governing the spread of epidemics in networks. Such parameters are typically estimated by measuring various characteristics (such as the number of…

Systems and Control · Electrical Eng. & Systems 2021-05-12 Lintao Ye , Philip E. Paré , Shreyas Sundaram

We propose a compartmental model for vector-transmitted diseases, such as Malaria and Dengue, spreading over complex networks. Individuals are represented by independent random walkers and vectors by infected nodes. Both walkers and nodes…

Populations and Evolution · Quantitative Biology 2025-05-05 Téo Granger , Thomas M. Michelitsch , Bernard A. Collet , Michael Bestehorn , Alejandro P. Riascos

The time varying effective reproduction number is an important parameter for communication and policy decisions during an epidemic. In this paper, we present new statistical methods for estimating the reproduction number based on the…

Methodology · Statistics 2025-10-02 Hans R. Künsch , Fabio Sigrist

We analyze a Markovian SIR epidemic model where individuals either recover naturally or are diagnosed, leading to isolation and potential contact tracing. Our focus is on digital contact tracing via a tracing app, considering both its…

Probability · Mathematics 2026-01-14 Tom Britton , Dongni Zhang

We present a mathematical model for within host viral infections that incorporates the Crowley Martin functional response, focusing on the dynamics influenced by periodic effects. This study establishes key properties of the model,…

Dynamical Systems · Mathematics 2025-03-14 Ibrahim Nali , Attila Dénes

Recent outbreaks of monkeypox and Ebola, and worrying waves of COVID-19, influenza and respiratory syncytial virus, have all led to a sharp increase in the use of epidemiological models to estimate key epidemiological parameters. The…

Populations and Evolution · Quantitative Biology 2023-12-01 B. K. M. Case , Jean-Gabriel Young , Laurent Hébert-Dufresne

A simplified method to compute $R_t$, the Effective Reproduction Number, is presented. The method relates the value of $R_t$ to the estimation of the doubling time performed with a local exponential fit. The condition $R_t = 1$ corresponds…

We consider the problem of estimating the reproduction number $R_t$ of an epidemic for populations where the probability of detection of cases depends on a known covariate. We argue that in such cases the normal empirical estimator can fail…

Applications · Statistics 2020-12-04 Guido Sanguinetti

We propose a new method in which a generative network (GN) integrate into a reduced-order model (ROM) framework is used to solve inverse problems for partial differential equations (PDE). The aim is to match available measurements and…

Machine Learning · Computer Science 2025-06-17 Vinicius L. S. Silva , Claire E. Heaney , Nenko Nenov , Christopher C. Pain

Many of the models used nowadays in mathematical epidemiology, in particular in COVID-19 research, belong to a certain sub-class of compartmental models whose classes may be divided into three "(x, y, z)" groups, which we will call…

Populations and Evolution · Quantitative Biology 2021-12-30 Florin Avram , Rim Adenane , David I. Ketcheson

Despite improved control measures, Ebola remains a serious public health risk in African regions where recurrent outbreaks have been observed since the initial epidemic in 1976. Using epidemic modeling and data from two well-documented…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Gerardo Chowell , Nick W. Hengartner , Carlos Castillo-Chavez , Paul W. Fenimore , J. M. Hyman