Related papers: DNA Sensing with Whispering Gallery Mode Microlase…
Image denoising plays a critical role in biomedical and microscopy imaging, especially when acquiring wide-field fluorescence-stained images. This task faces challenges in multiple fronts, including limitations in image acquisition…
Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…
Whispering gallery mode (WGM) microresonators, benefitting from the ultrahigh quality (Q) factors and small mode volumes, could considerably enhance the light-matter interaction, making it an ideal platform for studying a broad range of…
Navigation, bio-tracking devices and gravity gradiometry are amongst the diverse range of applications requiring ultrasensitive measurements of acceleration. We describe an accelerometer that exploits the dispersive and dissipative coupling…
The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…
Optical fiber sensing carries a number of potential advantages for diagnostics and biomarker detection and monitoring, yet particular challenges persist in linking molecular recognition events to a change in the refractive index. DNA…
Graph-structured data can be found in numerous domains, yet the scarcity of labeled instances hinders its effective utilization of deep learning in many scenarios. Traditional unsupervised domain adaptation (UDA) strategies for graphs…
In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological…
Silica and water are known as exceptionally inert chemical materials whose interaction is not completely understood. Here we show that the effect of this interaction can be significantly enhanced by optical whispering gallery modes (WGMs)…
The emerging field of DNA storage employs strands of DNA bases (A/T/C/G) as a storage medium for digital information to enable massive density and durability. The DNA storage pipeline includes: (1) encoding the raw data into sequences of…
In this paper, we present the design of a Deoxyribonucleic Acid (DNA) shearing system based on unique acoustic waves generated using a phased-array Fresnel Lens transducer. Four 90-degree sector-transducers are used to build a circular…
Diamond containing the negatively charged nitrogen-vacancy (NV) center is emerging as a significant new system for magnetometry. However, most NV sensors require microscopes to collect the fluorescence signals and are therefore limited to…
Genome modeling conventionally treats gene sequence as a language, reflecting its structured motifs and long-range dependencies analogous to linguistic units and organization principles such as words and syntax. Recent studies utilize…
Nonlinear optics in whispering-gallery-mode (WGM) microresonators have attracted much attention. Owing to strong confinement of the light in a small volume, a WGM microresonator can dramatically boost the strength of light field, giving…
DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function. To fully understand this molecular heterogeneity, DNA and…
The fundamentals of the whispering gallery mode (WGM) resonators are well established in the literature, with several successful proof-of-concept experiments. One remarkable benefit of this technology is the room-temperature operation. This…
Whispering gallery mode (WGM) microcavities can efficiently store and manipulate light with strong light confinement and long photon lifetime, while coupling light into and from WGMs is intrinsically hindered by their unique feature of…
Nanoparticle-induced modifications of the spectrum of whispering-gallery-modes (WGM) of optical spheroidal resonators are studied theoretically. Combining an ab initio solution of a single resonator problem with a dipole approximation for…
DNA methylation plays a pivotal role in the genetic evolution of both embryonic and adult cells. For adult somatic cells, location and dynamics of methylation has been very precisely pinned down with the 5-cytosine markers on…
We report on fabrication of whispering-gallery-mode microlasers in a Nd:glass chip by femtosecond laser three-dimensional (3D) micromachining. Main fabrication procedures include the fabrication of freestanding microdisks supported by thin…