Related papers: DNA Sensing with Whispering Gallery Mode Microlase…
The ability to detect and size individual nanoparticles with high resolution is crucial to understanding behaviours of single particles and effectively using their strong size-dependent properties to develop innovative products. We report…
The emerging field of hybrid DNA - protein nanotechnology brings with it the potential for many novel materials which combine the addressability of DNA nanotechnology with versatility of protein interactions. However, the design and…
We introduce a coarse-grained rigid nucleotide model of DNA that reproduces the basic thermodynamics of short strands: duplex hybridization, single-stranded stacking and hairpin formation, and also captures the essential structural…
DNA methylation is an important epigenetic mark that has been studied extensively for its regulatory role in biological processes and diseases. WGBS allows for genome-wide measurements of DNA methylation up to single-base resolutions, yet…
Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA…
Nature provides a set of solutions for photonic structures that are finely tuned, organically diverse and optically efficient. Exquisite knowledge of structure-property relationships in proteins aids in the design of materials with desired…
High-$Q$ whispering gallery mode microresonators are cornerstones to develop compact coherent sources like single frequency lasers or frequency combs. This work reports a detailed characterization of a whispering gallery mode microsphere in…
Genetic engineering of cells has a range of applications in treating incurable diseases. Plasmid DNA is a popular choice of nucleic acid for cell engineering due to its low cost and stability. However, plasmid DNA must survive the…
Our results demonstrate a new method for label-free, real-time oligonucleotide characterisation by their self-resonant modes, which are unique to their conformation and sequence. We anticipate that our assay will be used as a starting point…
In this paper, we study DNA-based molecular communication with microarray-style reception under reversible hybridization, where the bound-state observation exhibits both inter-symbol interference and colored counting noise. To capture these…
Controlled tuning of the whispering gallery modes of GaN/InGaN {\mu}-disk cavities is demonstrated. The whispering gallery mode (WGM) tuning is achieved at room temperature by immersing the {\mu}-disks in water and irradiating with…
Compact, low-noise coherent light sources in the visible remain challenging due to limited gain platforms and inefficient pumping. We report a new route to visible microlasing based on direct, one-photon blue pumping and an amorphous…
We propose a hybrid photonic-plasmonic resonant structure which consists of a metal nanoparticle (MNP) and a whispering gallery mode (WGM) microcavity. It is found that the hybrid mode enables a strong interaction between the light and…
Sensing biological forces with microscopic lasers is an emerging technique that offers significant advantages over conventional fluorescent probes and imaging-based techniques. However, the limited availability of suitable deformable or…
An ensemble of negatively charged nitrogen-vacancy centers in diamond can act as a precise quantum sensor even under ambient conditions. In particular, to optimize thier sensitivity, it is crucial to increase the number of spins sampled and…
Transcriptional profiling on microarrays to obtain gene expressions has been used to facilitate cancer diagnosis. We propose a deep generative machine learning architecture (called DeepCancer) that learn features from unlabeled microarray…
Electrical detection of messenger ribonucleic acid (mRNA) is a promising approach to enhancing transcriptomics and disease diagnostics because of its sensitivity, rapidity, and modularity. Reported here is a fast SARS-CoV-2 mRNA biosensor…
Whispering gallery mode (WGM) optical resonators utilizing resonance shift (RS) and mode splitting (MS) techniques have emerged as highly sensitive platforms for label-free detection of nano-scale objects. RS method has been demonstrated in…
Microcavities supporting Whispering-gallery modes (WGMs) are of great significance for on-chip optical information processing, which is frequently analyzed using ray dynamics that conventionally involves straight light trajectories in flat…
Spectroscopy of whispering-gallery mode (WGM) microresonators has become a powerful scientific tool, enabling detection of single viruses, nanoparticles, and even single molecules. Yet the demonstrated timescale of these schemes has been…