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The whispering gallery modes (WGMs) of optical resonators have prompted intensive research efforts due to their usefulness in the field of biological sensing, and their employment in nonlinear optics. While much information is available in…

Optical whispering gallery mode (WGM) microresonators, confining resonant photons in a microscale resonator for long periods of time, could strongly enhance light-matter interaction, making it an ideal platform for all kinds of sensors. In…

Optics · Physics 2021-07-06 Xuefeng Jiang , Abraham J. Qavi , Steven H. Huang , Lan Yang

Whispering gallery mode (WGM) resonators are garnering significant attention due to their unique characteristics and remarkable properties. When integrated with optical sensing and processing technology, WGM resonators offer numerous…

This work takes inspiration from chemistry where the spectral characteristics of the molecules are determined by hybridization of electronic states evolving from the individual atomic orbitals. Based on analogy between quantum mechanics and…

Whispering-gallery mode resonators host multiple trapped narrowband circulating optical resonances that find applications in quantum electrodynamics, optomechanics, and sensing. However, the spherical symmetry and low field leakage of…

Whispering gallery mode microlasers are known for their high Q-factors, characteristic emission spectra and sensitivity to local refractive index changes. This sensitivity combined with the ability of various cell types to internalise these…

Simple methods to detect biomolecules including specific nucleic acid sequences have received renewed attention since the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus pandemic. Notably, biomolecule detection that uses…

Biomolecules · Quantitative Biology 2024-09-09 A. A. Aldakheel , C. B. Raub , H. T. Bui

We demonstrated a biosensing approach which, for the first time, combines the high-sensitivity of whispering gallery modes (WGM) with a metallic nanoparticle based assay. We provided a computational model based on generalized Mie theory to…

Whispering gallery mode (WGM) laser sensors, utilizing the interaction between the in-plane evanescent field and the surface vicinity, provide enhanced sensitivity in label-free sensing for bioanalysis and disease screening. However, the…

Optics · Physics 2025-08-25 Xiaolu Cui , Jiyang Ma , Hao Wu , Shuoying Zhao , Xubiao Peng , Chuyu Li , Ruiqi Ming , Qing Zhao

Deoxyribonucleic acid (DNA) has shown great promise in enabling computational applications, most notably in the fields of DNA digital data storage and DNA computing. Information is encoded as DNA strands, which will naturally bind in…

Machine Learning · Computer Science 2021-10-22 David Buterez

Micro and nanoscale particles are crucial in various fields, from biomedical imaging to environmental processes. While conventional spectroscopy and microscopy methods for characterizing these particles often involve bulky equipment and…

Biological Physics · Physics 2024-11-26 Jie Liao , Maxwell Adolphson , Hangyue Li , Dipayon Kumar Sikder , Chenyang Lu , Lan Yang

Label-free detection techniques for single particles and molecules play an important role in basic science, disease diagnostics, and nanomaterial investigations. While traditional fluorescence-based methods offer powerful tools for single…

Optics · Physics 2024-08-20 Shuang Hao , Sartanee Suebka , Judith Su

A microfluidic whispering gallery mode (WGM) biosensing system is proposed for enhanced delivery and detection of target molecules. A microtoroid resonator coupled to a tapered optical fiber is immersed within a microfluidic channel, and…

Optics · Physics 2018-04-09 Kiran Khosla , Jon D. Swaim , Joachim Knittel , Warwick P. Bowen

This paper presents an electrolytically gated broadband microwave sensor where atomically-thin graphene layers are integrated into coplanar waveguides and coupled with microfluidic channels. The interaction between a solution under test and…

We report a comparison of two photonic techniques for single-molecule sensing: fluorescence nanoscopy and optoplasmonic sensing. As the test system, oligonucleotides with and without fluorescent labels are transiently hybridized to…

Studies of biochemical liquids require precise determination of their complex permittivity. We developed a microwave characterization technique on the basis of a high-quality whispering-gallery mode (WGM) sapphire resonator with a…

In combining DNA nanotechnology and high-bandwidth single-molecule detection in nanopipettes, we demonstrate an all-electric, label-free hybridisation sensor for short DNA sequences (< 100 nt). Such short fragments are known to occur as…

Detection and characterization of individual nano-scale particles, virions, and pathogens are of paramount importance to human health, homeland security, diagnostic and environmental monitoring[1]. There is a strong demand for…

Optics · Physics 2011-07-06 Lina He , Sahin Kaya Ozdemir , Jiangang Zhu , Woosung Kim , Lan Yang

Designing high-finesse resonant cavities for electronic waves faces challenges due to short electron coherence lengths in solids. Previous approaches, e.g. the seminal nanometer-sized quantum corrals, depend on careful positioning of…

Sensing with optical whispering gallery modes (WGMs) is a rapidly developing detection method in modern microfluidics research. This method explores the perturbations of spectra of WGMs propagating along the wall of an optical…