Plasmonic Nanoparticle-based Protein Detection by Optical Shift of a Resonant Microcavity
Optics
2011-08-12 v1 Instrumentation and Detectors
Abstract
We demonstrated a biosensing approach which, for the first time, combines the high-sensitivity of whispering gallery modes (WGM) with a metallic nanoparticle based assay. We provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection through Plasmonic enhancement. We quantitatively analyzed the binding of a model protein (i.e., BSA) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model.
Keywords
Cite
@article{arxiv.1108.2337,
title = {Plasmonic Nanoparticle-based Protein Detection by Optical Shift of a Resonant Microcavity},
author = {Miguel A. Santiago-Cordoba and Svetlana V. Boriskina and Frank Vollmer and Melik C. Demirel},
journal= {arXiv preprint arXiv:1108.2337},
year = {2011}
}
Comments
12 pages, three figures first submitted to APL March 4 2011