Related papers: Plasmonic Nanoparticle-based Protein Detection by …
Microcavity and whispering gallery mode (WGM) biosensors derive their sensitivity from monitoring frequency shifts induced by protein binding at sites of highly confined field intensities, where field strengths can be further amplified by…
We analyze a whispering gallery mode biosensor with a metallic nanorod bound to its surface. It is found that a localized surface plasmon resonance in the nanorod can reduce the optical mode volume of the resonator by as much as four orders…
Surface Plasmon Resonance sensors are a well-established class of sensors which includes a very large variety of materials and detection schemes. However, the development of portable devices is still challenging as due to the intrinsic…
Noble metal nanoparticles show specific optical properties due to the excitation of localized surface plasmons that make them attractive candidates for highly sensitive bionanosensors. The underlying physical principle is either an…
We performed a visualization of membrane proteins labeled with 10-nm gold nanoparticles in cells, using an all-optical method based on photothermal interference contrast. The high sensitivity of the method and the stability of the signals…
Micro and nanoscale particles are crucial in various fields, from biomedical imaging to environmental processes. While conventional spectroscopy and microscopy methods for characterizing these particles often involve bulky equipment and…
Biophotonics - and more recently, biointegrated photonics - offer transformative tools for probing cellular processes with unprecedented precision. Among these, whispering gallery mode (WGM) resonators - optical microcavities formed in…
Plasmonic lasers provide a paradigm-changing approach for the generation of coherent light at the nanoscale. In addition to the usual properties of coherent radiation, the emission of plasmonic lasers can feature high sensitivity to the…
There is a crucial need for effective and easily dispersible colloidal microsensors able to detect local pH changes before irreversible damages caused by demineralization, corrosion, or biofilms occur. One class of such microsensors is…
Sequence coverage in MS analysis of protein digestion-derived peptides is a key issue for detailed characterization of proteins or identification at low quantities. In gel-based proteomics studies, the sequence coverage greatly depends on…
Nanoparticle-induced modifications of the spectrum of whispering-gallery-modes (WGM) of optical spheroidal resonators are studied theoretically. Combining an ab initio solution of a single resonator problem with a dipole approximation for…
Current optical detection schemes for single molecules require light absorption, either to produce fluorescence or direct absorption signals. This severely limits the range of molecules that can be detected, because most molecules are…
We detect 39 nm x 10 nm gold nanorods using a microtoroid stabilized via the Pound-Drever-Hall method. Real-time detection is achieved with signal-to-noise ratios up to 12.2. These nanoparticles are a factor of three smaller in volume than…
Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the…
We propose a hybrid photonic-plasmonic resonant structure which consists of a metal nanoparticle (MNP) and a whispering gallery mode (WGM) microcavity. It is found that the hybrid mode enables a strong interaction between the light and…
Regular arrays of metal nanoparticles on metal films have tuneable optical resonances that can be applied for surface enhanced Raman scattering or biosensing. With the aim of developing more surface selective geometries we investigate…
Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive realtime observation of motor molecule motion. However, to date…
We report a theoretical study of clusters of evanescently-coupled 2D whispering-gallery (WG) mode optical micro-cavities (termed "photonic molecules") as chemosensing and biosensing platforms. Photonic molecules (PMs) supporting modes with…
Optical biosensors are indispensable in medical and environmental diagnostics, yet existing approaches are fundamentally limited in their sensitivity due to ensemble-averaged measurements. Digital biosensing has emerged as a promising…
Plasmonic devices, fundamental to modern nanophotonics, exploit resonant interactions between light and free electrons in metals to achieve enhanced light trapping and electromagnetic field confinement. However, modeling their complex,…