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Phylogenetic networks extend phylogenetic trees to model non-vertical inheritance, by which a lineage inherits material from multiple parents. The computational complexity of estimating phylogenetic networks from genome-wide data with…

Populations and Evolution · Quantitative Biology 2022-06-28 Jingcheng Xu , Cécile Ané

We consider the classical estimation problem of an unknown drift parameter within classes of nondegenerate diffusion processes. Using rough path theory (in the sense of T. Lyons), we analyze the Maximum Likelihood Estimator (MLE) with…

Probability · Mathematics 2016-09-29 Joscha Diehl , Peter Friz , Hilmar Mai

We introduce a simple modification to the standard maximum likelihood estimation (MLE) framework. Rather than maximizing a single unconditional likelihood of the data under the model, we maximize a family of \textit{noise conditional}…

Machine Learning · Computer Science 2022-10-20 Henry Li , Yuval Kluger

This study focuses on the estimation of the Emax dose-response model, a widely utilized framework in clinical trials, agriculture, and environmental experiments. Existing challenges in obtaining maximum likelihood estimates (MLE) for model…

Methodology · Statistics 2025-06-11 Giacomo Aletti , Nancy Flournoy , Caterina May , Chiara Tommasi

The mathematical analysis of random phylogenetic networks via analytic and algorithmic methods has received increasing attention in the past years. In the present work we introduce branching process methods to their study. This approach…

Probability · Mathematics 2021-02-23 Benedikt Stufler

In the critical beta-splitting model of a random $n$-leaf rooted tree, clades are recursively (from the root) split into sub-clades, and a clade of $m$ leaves is split into sub-clades containing $i$ and $m-i$ leaves with probabilities…

Probability · Mathematics 2025-04-21 David J. Aldous , Svante Janson

Electromagnetic field reconstruction is crucial in many applications, including antenna diagnostics, electromagnetic interference analysis, and system modeling. This paper presents a deep learning-based approach for Far-Field to Near-Field…

Machine Learning · Computer Science 2025-04-25 Sahar Bagherkhani , Jackson Christopher Earls , Franco De Flaviis , Pierre Baldi

This paper presents a new Graph Neural Network (GNN) type using feature-wise linear modulation (FiLM). Many standard GNN variants propagate information along the edges of a graph by computing "messages" based only on the representation of…

Machine Learning · Computer Science 2020-06-29 Marc Brockschmidt

A big challenge in branch and bound lies in identifying the optimal node within the search tree from which to proceed. Current state-of-the-art selectors utilize either hand-crafted ensembles that automatically switch between naive sub-node…

Machine Learning · Computer Science 2024-06-06 Alexander Mattick , Christopher Mutschler

A complexity-adaptive tree search algorithm is proposed for $\boldsymbol{G}_N$-coset codes that implements maximum-likelihood (ML) decoding by using a successive decoding schedule. The average complexity is close to that of the successive…

Information Theory · Computer Science 2021-09-03 Peihong Yuan , Mustafa Cemil Coşkun

This work proposes a very simple random matrix model, the Flip Matrix Model, liable to approximate the behavior of a two dimensional electron in a weak random potential. Its construction is based on a phase space analysis, a suitable…

Statistical Mechanics · Physics 2007-05-23 J. Bellissard , J. Magnen , V. Rivasseau

Least squares trees, multi-dimensional scaling and Neighbor Nets are all different and popular ways of visualizing multi-dimensional data. The method of flexi-Weighted Least Squares (fWLS) is a powerful method of fitting phylogenetic trees,…

Populations and Evolution · Quantitative Biology 2010-12-30 Peter J. Waddell , Ishita Khan , Xi Tan , Sunghwan Yoo

Estimating model parameters is a crucial step in mathematical modelling and typically involves minimizing the disagreement between model predictions and experimental data. This calibration data can change throughout a study, particularly if…

Quantitative Methods · Quantitative Biology 2023-11-03 Tyler Cassidy

Normal networks are an important class of phylogenetic networks that have compelling mathematical properties which align with intuition about inference from genetic data. While tools enabling widespread use of phylogenetic networks in the…

Combinatorics · Mathematics 2025-12-16 Andrew Francis , Charles Semple

In regression analysis under artificial neural networks, the prediction performance depends on determining the appropriate weights between layers. As randomly initialized weights are updated during back-propagation using the gradient…

Machine Learning · Computer Science 2020-09-09 Eunho Koo , Hyungjun Kim

An important problem of reconstruction of diffusion network and transmission probabilities from the data has attracted a considerable attention in the past several years. A number of recent papers introduced efficient algorithms for the…

Physics and Society · Physics 2015-09-24 Andrey Y. Lokhov , Theodor Misiakiewicz

The goal of the trace reconstruction problem is to recover a string $x\in\{0,1\}^n$ given many independent {\em traces} of $x$, where a trace is a subsequence obtained from deleting bits of $x$ independently with some given probability…

Information Theory · Computer Science 2024-01-30 Kuan Cheng , Elena Grigorescu , Xin Li , Madhu Sudan , Minshen Zhu

Phylogenetic trees are leaf-labelled trees used to model the evolution of species. In practice it is not uncommon to obtain two topologically distinct trees for the same set of species, and this motivates the use of distance measures to…

Data Structures and Algorithms · Computer Science 2026-03-24 David Mestel , Steven Chaplick , Steven Kelk , Ruben Meuwese

We present an efficient and flexible method for computing likelihoods of phenotypic traits on a phylogeny. The method does not resort to Monte-Carlo computation but instead blends Felsenstein's discrete character pruning algorithm with…

Populations and Evolution · Quantitative Biology 2015-12-04 Gordon Hiscott , Colin Fox , Matthew Parry , David Bryant

In phylogenetics, tree-based networks are used to model and visualize the evolutionary history of species where reticulate events such as horizontal gene transfer have occurred. Formally, a tree-based network $N$ consists of a phylogenetic…

Discrete Mathematics · Computer Science 2020-08-21 Jonathan Klawitter , Peter Stumpf