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Quantifying the dynamics of tumor burden reveals useful information about cancer evolution concerning treatment effects and drug resistance, which play a crucial role in advancing model-informed drug developments (MIDD) towards personalized…

Other Quantitative Biology · Quantitative Biology 2023-01-10 Nam Nguyen , Kwang-Cheng Chen

In its broadest terms, doctoral dissertation entitled "Track structure modelling for ion radiotherapy" is part of the supporting research background in the development of the ambitious proton radiotherapy project currently under way at the…

Medical Physics · Physics 2014-10-21 Marta Korcyl

Biomedical optical imaging has a possibility of a comprehensive diagnosis of thyroid cancer in conjunction with ultrasound imaging. For improvement of the optical imaging, this study develops a higher order scheme for solving the…

Medical Physics · Physics 2016-03-15 Hiroyuki Fujii , Shinpei Okawa , Ken Nadamoto , Eiji Okada , Yukio Yamada , Yoko Hoshi , Masao Watanabe

We present an efficient and robust numerical model for simulation of electrokinetic phenomena in porous networks over a wide range of applications including energy conversion, desalination, and lab-on-a-chip systems. Coupling between fluid…

Fluid Dynamics · Physics 2016-10-04 Shima Alizadeh , Ali Mani

We establish a general mechanism for highly efficient quantum transport through finite, disordered 3D networks. It relies on the interplay of disorder with centro-symmetry and a dominant doublet spectral structure, and can be controlled by…

The traditional picture of heat transfer in solids by atomic vibrations, also known as phonons, involves phonons scattering with each other like gas particles and is commonly referred to as the phonon gas model (PGM). This physical picture…

Materials Science · Physics 2021-08-11 Andrew Rohskopf , Ruiyang Li , Tengfei Luo , Asegun Henry

Port-based teleportation (PBT) is a variant of quantum teleportation that, unlike the canonical protocol by Bennett et al., does not require a correction operation on the teleported state. Since its introduction by Ishizaka and Hiroshima in…

Quantum Physics · Physics 2024-05-24 Dmitry Grinko , Adam Burchardt , Maris Ozols

We present a machine learning based approach to address the study of transport processes, ubiquitous in continuous mechanics, with particular attention to those phenomena ruled by complex micro-physics, impractical to theoretical…

Plasma Physics · Physics 2022-06-16 Francesco Miniati , Gianluca Gregori

Purpose: This study explores the feasibility of dose-escalated proton beam therapy (dPBT) for Locally Advanced Pancreatic Cancer (LAPC) patients by modeling common patient scenarios using current clinically-adopted practices. Methods: Five…

Medical Physics · Physics 2025-07-30 M. A. McIntyre , J. Midson , P. Wilson , P Gorayski , C. E. Hsieh , S. W. Wu , E. Bezak

Positron emission tomography (PET) is an advanced medical imaging technique that plays a crucial role in non-invasive clinical diagnosis. However, while reducing radiation exposure through low-dose PET scans is beneficial for patient…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Bin Huang , Xubiao Liu , Lei Fang , Qiegen Liu , Bingxuan Li

The determination of relative stopping power (RSP) via proton computed tomography (pCT) of a patient is dependent in part on the knowledge of the incoming proton kinetic energies; the uncertainty in these energies is in turn determined by…

Hadrontherapy is a novel technique of cancer radiation therapy which employs beams of charged hadrons, protons and carbon ions in particular. Due to their physical and radiobiological properties, they allow one to obtain a more conformal…

Medical Physics · Physics 2015-05-14 Saverio Braccini

Approximation methods for calculating individual particle/ field motions in spacetime at the quantum level of accuracy (a key feature of the Bohm Picture of Quantum Mechanics (BP)), are studied. Modern textbook presentations of Quantum…

Nuclear Theory · Physics 2009-04-17 A. Miranda

Purpose: Variations in proton Relative Biological Effectiveness (RBE) with Linear Energy Transfer (LET) remain one of the largest sources of uncertainty in proton radiotherapy. This work seeks to identify physics-based metrics which can be…

Medical Physics · Physics 2018-12-05 Stephen J McMahon , Harald Paganetti , Kevin M Prise

Technologies based on the use of hydrogen are promising for future energy requirements in a more sustainable world. Consequently, modelling fuel cells is crucial, for instance, to optimize their control to achieve excellent performance, to…

Systems and Control · Electrical Eng. & Systems 2024-10-18 Raphaël Gass , Zhongliang Li , Rachid Outbib , Samir Jemei , Daniel Hissel

Proton therapy is a modality in fast development. Characterized by a maximum dose deposition at the end of the proton trajectory followed by a sharp fall-off, proton beams can deliver a highly conformal dose to the tumor while sparing…

Medical Physics · Physics 2022-05-18 François Smekens , Nicolas Freud , Bruno Sixou , Guillaume Beslon , Jean M Létang

An effective radiative divertor maximizes the utilization of atomic processes to spread out the energy deposition to the divertor chamber walls and to reduce the peak heat flux. Because the mixture of neutral atoms and ions in the divertor…

plasm-ph · Physics 2009-10-28 A. S. Wan , H. E. Dalhed , H. A. Scott , D. E. Post , T. D. Rognlien

Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from…

Trapped Bosons exhibit fundamental physical phenomena and are potentially useful for quantum technologies. We present a method for simulating Bosons using path integral molecular dynamics. A main challenge for simulations is including all…

Quantum Gases · Physics 2020-05-07 Barak Hirshberg , Valerio Rizzi , Michele Parrinello

Back translation (BT) is one of the most significant technologies in NMT research fields. Existing attempts on BT share a common characteristic: they employ either beam search or random sampling to generate synthetic data with a backward…

Computation and Language · Computer Science 2023-12-25 Jiahao Xu , Yubin Ruan , Wei Bi , Guoping Huang , Shuming Shi , Lihui Chen , Lemao Liu