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Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…

Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…

Medical Physics · Physics 2022-11-02 Valentin Hamaide , Kevin Souris , Damien Dasnoy , Francois Glineur , Benoit Macq

We present a generalized multinodal model for simulating particle and energy transport in toroidal plasma configurations, developed to support burning plasma analysis and reactor-scale modeling. Unlike fixed-node models, this formulation…

Plasma Physics · Physics 2025-07-21 Zefang Liu , Weston M. Stacey

Positron Emission Tomography (PET) is an imaging technique which can be used to investigate chemical changes in human biological processes such as cancer development or neurochemical reactions. Most dynamic PET scans are currently analyzed…

Applications · Statistics 2014-11-11 Ci-Ren Jiang , John A D Aston , Jane-Ling Wang

Proton computed tomography (pCT) is an image modality that will improve treatment planning for patients receiving proton radiation therapy compared with the current treatment techniques, which are based on X-ray CT. Reconstruction of a pCT…

Medical Physics · Physics 2021-08-30 Micah Witt , Blake Schultze , Reinhard Schulte , Keith Schubert , Ernesto Gomez

Quantum teleportation is one of the fundamental building blocks of quantum Shannon theory. While ordinary teleportation is simple and efficient, port-based teleportation (PBT) enables applications such as universal programmable quantum…

Systems biology and whole-cell modelling are demanding increasingly comprehensive mathematical models of cellular biochemistry. These models require the development of simplified models of specific processes which capture essential…

Quantitative Methods · Quantitative Biology 2020-08-03 Peter J. Gawthrop , Peter Cudmore , Edmund J. Crampin

A programmable quantum networks model is used in this paper for development of methods of control of a quantum state transport. These methods may be applied for a wide variety of patterns of controlled state transmission and spreading in…

Quantum Physics · Physics 2007-09-12 Alexander Yu. Vlasov

We present multiscale models of cancer tumor invasion with components at the molecular, cellular, and tissue levels. We provide biological justifications for the model components, present computational results from the model, and discuss…

Quantitative Methods · Quantitative Biology 2023-02-14 Bruce P. Ayati , Glenn F. Webb , Alexander R. A. Anderson

Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct…

Understanding the relationship between the structure of light-harvesting systems and their excitation energy transfer properties is of fundamental importance in many applications including the development of next generation photovoltaics.…

Chemical Physics · Physics 2017-07-21 Florian Häse , Christoph Kreisbeck , Alán Aspuru-Guzik

A model for beam customization with collimators and a range-compensating filter based on the phase-space theory for beam transport is presented for dose distribution calculation in treatment planning of radiotherapy with protons and heavier…

Medical Physics · Physics 2008-05-27 Nobuyuki Kanematsu , Shunsuke Yonai , Azusa Ishizaki , Masami Torikoshi

A plasma transport theory that spans weak to strong coupling is developed from a binary collision picture, but where the interaction potential is taken to be an effective potential that includes correlation effects and screening…

Plasma Physics · Physics 2016-05-11 Scott D. Baalrud , Jerome Daligault

Boron Neutron Capture Therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction 10B(n,$\alpha$)7Li, consisting in the exposition of patients to neutron…

Thoroughly understanding the transport and energy loss of intense ion beams in dense matter is essential for high-energy-density physics and inertial confinement fusion. Here, we report a stopping power experiment with a high-intensity…

In this work, we report on the advantageous aspects of the i-TED Compton imager for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that…

We propose a fast beam orientation selection method, based on deep neural networks (DNN), capable of developing a plan comparable to those by the state-of-the-art column generation method. The novelty of Our model lies in its supervised…

Medical Physics · Physics 2019-12-23 Azar Sadeghnejad Barkousaraie , Olalekan Ogunmolu , Steve Jiang , Dan Nguyen

This work is the second part of a simulation study investigating the processing of densely packed and moving granular assemblies by positron emission particle tracking (PEPT). Since medical PET scanners commonly used for PEPT are very…

A protocol for fast and robust magnon transport in a one-dimensional spin chain is devised. Employing an approximate mapping between the chain and a single harmonically trapped particle, we exploit the known analytic control protocols for…

Quantum Physics · Physics 2021-03-30 Anthony Kiely , Steve Campbell

This contribution describes general concepts for control and safety systems in proton therapy. These concepts are illustrated by concrete examples implemented in the Proscan facility at PSI.

Medical Physics · Physics 2018-04-25 Martin Grossmann