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Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient…

We study the problem of finding an optimal radiotherapy treatment plan. A time-dependent Boltzmann particle transport model is used to model the interaction between radiative particles with tissue. This model allows for the modeling of…

Optimization and Control · Mathematics 2015-03-19 Richard Barnard , Martin Frank , Michael Herty

Proton Computed Tomography (pCT) provides a promising solution to enhance the accuracy of Relative Stopping Power (RSP) required for proton therapy planning. This research introduces a novel high-granularity pCT architecture that…

Proton therapy provides superior dose conformity compared with photon radiotherapy, concentrating radiation within the tumor while sparing adjacent healthy tissue. This advantage has been most effectively realized for static tumors in…

Medical Physics · Physics 2025-10-09 Vivek Maradia , Nick Yue , Adam Molzahn , Jingqian Wang , Mark Pankuch , Serdar Charyyev , Billy W. Loo

Radiation therapy is an effective and widely accepted form of treatment for many types of cancer that requires extensive computerized planning. Unfortunately, current treatment planning systems have limited or no visual aid that combines…

Graphics · Computer Science 2018-11-30 Felix G. Hamza-Lup , Ivan Sopin , Omar Zeidan

Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…

Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…

Medical Physics · Physics 2024-11-28 Aoxiang Wang , Ya-Nan Zhu , Jufri Setianegara , Yuting Lin , Peng Xiao , Qingguo Xie , Hao Gao

In this study, two proton beam delivery designs, passive scattering proton therapy (PSPT) and pencil beam scanning (PBS), were quantitatively compared in terms of dosimetric indices. The GATE Monte Carlo code was used to simulate the proton…

Medical Physics · Physics 2022-09-21 A. Asadi , A. Akhavanallaf , S. A. Hosseini , H. Zaidi

Proton transfer reactions are fundamental to many chemical and biological systems, where quantum effects such as tunneling, delocalization, and zero-point motion play key kinetic control roles. However, classical methods capable of…

Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while sparing healthy tissues. However, the clinical implementation is…

This report outlines the concepts, mechanisms and inner dynamics of the BEAM (Behavior, Energy, Autonomy, and Mobility) modeling framework. BEAM is an open-source large-scale high-resolution transportation model that harnesses the…

Multiagent Systems · Computer Science 2023-08-07 Haitam Laarabi , Zachary Needell , Rashid Waraich , Cristian Poliziani , Tom Wenzel

In this paper we propose a solution to the need for a fast particle transport algorithm in Online Adaptive Proton Therapy capable of cheaply, but accurately computing the changes in patient dose metrics as a result of changes in the system…

Medical Physics · Physics 2022-08-26 Tiberiu Burlacu , Danny Lathouwers , Zoltán Perkó

Ubiquitous mobile devices are generating vast amounts of location-based service data that reveal how individuals navigate and utilize urban spaces in detail. In this study, we utilize these extensive, unlabeled sequences of user…

Machine Learning · Computer Science 2024-06-06 Xinhua Wu , Haoyu He , Yanchao Wang , Qi Wang

We introduce a modeling framework for an urban tram network based on a hyperbolic partial differential equation describing the transport of passengers along the network, coupled with a family of stochastic processes representing passenger…

Numerical Analysis · Mathematics 2026-02-27 Thomas Schillinger

Background and purpose: In-beam Positron Emission Tomography (PET) is one of the modalities that can be used for in-vivo non-invasive treatment monitoring in proton therapy. PET distributions obtained during various treatment sessions can…

Electromagnetic radiation plays a crucial role in various physical and chemical processes. Hence, almost all astrophysical simulations require some form of radiative transfer model. Despite many innovations in radiative transfer algorithms…

Instrumentation and Methods for Astrophysics · Physics 2022-12-07 Frederik De Ceuster , Thomas Ceulemans , Jon Cockayne , Leen Decin , Jeremy Yates

In this manuscript we analyse generalised port-based teleportation (PBT) schemes, allowing for transmitting more than one unknown quantum state (or a composite quantum state) in one go, where the state ends up in several ports at Bob's…

Quantum Physics · Physics 2022-11-28 Michał Studziński , Marek Mozrzymas , Piotr Kopszak , Michał Horodecki

The process of protons transport in molecular water chains is of fundamental interest for many biological systems. Although many features of such systems can be analyzed using large-scale computational modeling, other features are better…

Biological Physics · Physics 2011-08-23 Artem Korzhimanov , Mattias Marklund , Tatiana Shutova , Goran Samuelsson

Physical and biological range uncertainties limit the clinical potential of Proton Beam Therapy (PBT). In this proceedings, we report on two research projects, which we are conducting in parallel and which both tackle the problem of range…

Pre-trained Transformer-based models have achieved state-of-the-art performance for various Natural Language Processing (NLP) tasks. However, these models often have billions of parameters, and, thus, are too resource-hungry and…

Machine Learning · Computer Science 2021-09-29 Prakhar Ganesh , Yao Chen , Xin Lou , Mohammad Ali Khan , Yin Yang , Hassan Sajjad , Preslav Nakov , Deming Chen , Marianne Winslett