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Large-scale biological discovery requires integrating massive, heterogeneous datasets like those from the JUMP Cell Painting consortium, but technical batch effects and a lack of generalizable models remain critical roadblocks. To address…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Cedric Caruzzo , Jong Chul Ye

Representation learning is a central challenge across a range of machine learning areas. In reinforcement learning, effective and functional representations have the potential to tremendously accelerate learning progress and solve more…

Machine Learning · Computer Science 2019-01-30 Dibya Ghosh , Abhishek Gupta , Sergey Levine

Causal reasoning and compositional reasoning are two core aspirations in AI. Measuring the extent of these behaviors requires principled evaluation methods. We explore a unified perspective that considers both behaviors simultaneously,…

Computation and Language · Computer Science 2025-06-11 Jacqueline R. M. A. Maasch , Alihan Hüyük , Xinnuo Xu , Aditya V. Nori , Javier Gonzalez

Unobserved confounding is a fundamental challenge for estimating causal effects. To address unobserved confounding, recent literature has turned to two different approaches -- proxy variables and the use of multiple treatments. The first…

Methodology · Statistics 2026-05-20 Aytijhya Saha , Stephen Bates , Devavrat Shah

Learning causal relationships among a set of variables, as encoded by a directed acyclic graph, from observational data is complicated by the presence of unobserved confounders. Instrumental variables (IVs) are a popular remedy for this…

Methodology · Statistics 2025-04-17 Jing Zou , Wei Li , Wei Lin

As a pivotal component to attaining generalizable solutions in human intelligence, reasoning provides great potential for reinforcement learning (RL) agents' generalization towards varied goals by summarizing part-to-whole arguments and…

Machine Learning · Computer Science 2023-05-18 Wenhao Ding , Haohong Lin , Bo Li , Ding Zhao

Causal inference and model interpretability are gaining increasing attention, particularly in the biomedical domain. Despite recent advance, decorrelating features in nonlinear environments with human-interpretable representations remains…

Machine Learning · Computer Science 2024-11-12 Junda Wang , Weijian Li , Han Wang , Hanjia Lyu , Caroline P. Thirukumaran , Addisu Mesfin , Hong Yu , Jiebo Luo

This work extends the theory of identifiability in supervised learning by considering the consequences of having access to a distribution of tasks. In such cases, we show that linear identifiability is achievable in the general multi-task…

Machine Learning · Statistics 2024-08-26 Wenlin Chen , Julien Horwood , Juyeon Heo , José Miguel Hernández-Lobato

Learning meaningful causal representations from observations has emerged as a crucial task for facilitating machine learning applications and driving scientific discoveries in fields such as climate science, biology, and physics. This…

Machine Learning · Computer Science 2026-02-06 Jiaxu Ren , Yixin Wang , Biwei Huang

Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in…

Machine Learning · Statistics 2017-10-31 Dustin Tran , David M. Blei

In text classification tasks, models often rely on spurious correlations for predictions, incorrectly associating irrelevant features with the target labels. This issue limits the robustness and generalization of models, especially when…

Machine Learning · Computer Science 2025-02-04 Yuqing Zhou , Ziwei Zhu

Predicting and enhancing inherent properties based on molecular structures is paramount to design tasks in medicine, materials science, and environmental management. Most of the current machine learning and deep learning approaches have…

Machine Learning · Computer Science 2024-04-08 Zachary R. Fox , Ayana Ghosh

Recently in the field of unsupervised representation learning, strong identifiability results for disentanglement of causally-related latent variables have been established by exploiting certain side information, such as class labels, in…

Machine Learning · Computer Science 2022-10-26 Weiran Yao , Guangyi Chen , Kun Zhang

Sequential experimental design to discover interventions that achieve a desired outcome is a key problem in various domains including science, engineering and public policy. When the space of possible interventions is large, making an…

Machine Learning · Computer Science 2023-08-17 Jiaqi Zhang , Louis Cammarata , Chandler Squires , Themistoklis P. Sapsis , Caroline Uhler

Many causal systems such as biological processes in cells can only be observed indirectly via measurements, such as gene expression. Causal representation learning -- the task of correctly mapping low-level observations to latent causal…

Machine Learning · Computer Science 2025-10-31 Elliot Layne , Jason Hartford , Sébastien Lachapelle , Mathieu Blanchette , Dhanya Sridhar

Unsupervised representation learning with variational inference relies heavily on independence assumptions over latent variables. Causal representation learning (CRL), however, argues that factors of variation in a dataset are, in fact,…

Machine Learning · Computer Science 2023-07-13 Avinash Kori , Pedro Sanchez , Konstantinos Vilouras , Ben Glocker , Sotirios A. Tsaftaris

Integrating causal inference (CI) with reinforcement learning (RL) has emerged as a powerful paradigm to address critical limitations in classical RL, including low explainability, lack of robustness and generalization failures. Traditional…

Artificial Intelligence · Computer Science 2025-12-23 Cristiano da Costa Cunha , Wei Liu , Tim French , Ajmal Mian

Humans learn quickly even in tasks that contain complex visual information. This is due in part to the efficient formation of compressed representations of visual information, allowing for better generalization and robustness. However,…

Artificial Intelligence · Computer Science 2025-05-16 Tailia Malloy , Miao Liu , Matthew D. Riemer , Tim Klinger , Gerald Tesauro , Chris R. Sims

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

Machine Learning · Computer Science 2023-04-26 Payam Dibaeinia , Saurabh Sinha

Inducing causal relationships from observations is a classic problem in machine learning. Most work in causality starts from the premise that the causal variables themselves are observed. However, for AI agents such as robots trying to make…

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