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Predicting clinical outcomes to anti-cancer drugs on a personalized basis is challenging in cancer treatment due to the heterogeneity of tumors. Traditional computational efforts have been made to model the effect of drug response on…

Machine Learning · Computer Science 2022-07-12 Jie Gao , Jing Hu , Wanqing Sun , Yili Shen , Xiaonan Zhang , Xiaomin Fang , Fan Wang , Guodong Zhao

Unveil, model, and comprehend the causal mechanisms underpinning natural phenomena stand as fundamental endeavors across myriad scientific disciplines. Meanwhile, new knowledge emerges when discovering causal relationships from data.…

Machine Learning · Computer Science 2023-12-13 Jiaxuan Liang , Jun Wang , Guoxian Yu , Shuyin Xia , Guoyin Wang

Learning representations purely from observations concerns the problem of learning a low-dimensional, compact representation which is beneficial to prediction models. Under the hypothesis that the intrinsic latent factors follow some casual…

Machine Learning · Computer Science 2023-10-24 Mengyue Yang , Xinyu Cai , Furui Liu , Weinan Zhang , Jun Wang

In a wide range of multimodal tasks, contrastive learning has become a particularly appealing approach since it can successfully learn representations from abundant unlabeled data with only pairing information (e.g., image-caption or…

Machine Learning · Computer Science 2023-10-31 Paul Pu Liang , Zihao Deng , Martin Ma , James Zou , Louis-Philippe Morency , Ruslan Salakhutdinov

In designing generative models, it is commonly believed that in order to learn useful latent structure, we face a fundamental tension between expressivity and structure. In this paper we challenge this view by proposing a new approach to…

Machine Learning · Statistics 2026-04-03 Alex Markham , Isaac Hirsch , Jeri A. Chang , Liam Solus , Bryon Aragam

Federated learning is a distributed framework designed to address privacy concerns. However, it introduces new attack surfaces, which are especially prone when data is non-Independently and Identically Distributed. Existing approaches fail…

Cryptography and Security · Computer Science 2025-05-27 Hyejun Jeong , Hamin Son , Seohu Lee , Jayun Hyun , Tai-Myoung Chung

We study the problem of experiment design to learn causal structures from interventional data. We consider an active learning setting in which the experimenter decides to intervene on one of the variables in the system in each step and uses…

Artificial Intelligence · Computer Science 2020-09-09 Amir Amirinezhad , Saber Salehkaleybar , Matin Hashemi

Data-driven individualized decision making has recently received increasing research interests. Most existing methods rely on the assumption of no unmeasured confounding, which unfortunately cannot be ensured in practice especially in…

Methodology · Statistics 2022-12-26 Zhengling Qi , Rui Miao , Xiaoke Zhang

Dynamic treatment regimes (DTRs) are used in medicine to tailor sequential treatment decisions to patients by considering patient heterogeneity. Common methods for learning optimal DTRs, however, have shortcomings: they are typically based…

Machine Learning · Statistics 2023-06-21 Theresa Blümlein , Joel Persson , Stefan Feuerriegel

Causal discovery serves a pivotal role in mitigating model uncertainty through recovering the underlying causal mechanisms among variables. In many practical domains, such as healthcare, access to the data gathered by individual entities is…

Machine Learning · Computer Science 2024-02-13 Amin Abyaneh , Nino Scherrer , Patrick Schwab , Stefan Bauer , Bernhard Schölkopf , Arash Mehrjou

Causal discovery is the challenging task of inferring causal structure from data. Motivated by Pearl's Causal Hierarchy (PCH), which tells us that passive observations alone are not enough to distinguish correlation from causation, there…

Machine Learning · Computer Science 2024-01-31 Andreas W. M. Sauter , Nicolò Botteghi , Erman Acar , Aske Plaat

Causal inference and model interpretability research are gaining increasing attention, especially in the domains of healthcare and bioinformatics. Despite recent successes in this field, decorrelating features under nonlinear environments…

Machine Learning · Computer Science 2022-09-30 Junda Wang , Weijian Li , Han Wang , Hanjia Lyu , Caroline Thirukumaran , Addisu Mesfin , Jiebo Luo

We consider linear structural equation models with explicitly modelled latent variables. In such models, observed and latent variables solve linear equations including stochastic noise terms. The goal of our work is to identify the direct…

Methodology · Statistics 2026-05-28 Tom Hochsprung , Nils Sturma , Jakob Runge , Mathias Drton , Andreas Gerhardus

Granger causality, commonly used for inferring causal structures from time series data, has been adopted in widespread applications across various fields due to its intuitive explainability and high compatibility with emerging deep neural…

Machine Learning · Computer Science 2024-06-18 Ziyi Zhang , Shaogang Ren , Xiaoning Qian , Nick Duffield

Rule-based models, e.g., decision trees, are widely used in scenarios demanding high model interpretability for their transparent inner structures and good model expressivity. However, rule-based models are hard to optimize, especially on…

Machine Learning · Computer Science 2021-10-01 Zhuo Wang , Wei Zhang , Ning Liu , Jianyong Wang

The prevailing graph neural network models have achieved significant progress in graph representation learning. However, in this paper, we uncover an ever-overlooked phenomenon: the pre-trained graph representation learning model tested…

Machine Learning · Computer Science 2023-02-14 Hang Gao , Jiangmeng Li , Wenwen Qiang , Lingyu Si , Bing Xu , Changwen Zheng , Fuchun Sun

Causal representation learning (CRL) seeks to recover latent variables with identifiability guarantees, typically up to permutation and component-wise reparameterization under appropriate assumptions. However, identifiability does not imply…

Machine Learning · Computer Science 2026-05-08 Shicheng Fan , Nour Elhendawy , Jianle Sun , Ke Fang , Kun Zhang , Yihang Wang , Lu Cheng

Causal structure discovery from observational data is fundamental to the causal understanding of autonomous systems such as medical decision support systems, advertising campaigns and self-driving cars. This is essential to solve well-known…

In recent years, there has been a growing interest in using machine learning techniques for the estimation of treatment effects. Most of the best-performing methods rely on representation learning strategies that encourage shared behavior…

Machine Learning · Computer Science 2024-04-19 Roger Pros , Jordi Vitrià

Identifying latent representations or causal structures is important for good generalization and downstream task performance. However, both fields have been developed rather independently. We observe that several methods in both…

Machine Learning · Statistics 2025-02-11 Patrik Reizinger , Siyuan Guo , Ferenc Huszár , Bernhard Schölkopf , Wieland Brendel
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