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Goal-conditioned reinforcement learning (RL) is a promising direction for training agents that are capable of solving multiple tasks and reach a diverse set of objectives. How to \textit{specify} and \textit{ground} these goals in such a…

Due to the challenge posed by multi-source and heterogeneous data collected from diverse environments, causal relationships among features can exhibit variations influenced by different time spans, regions, or strategies. This diversity…

Machine Learning · Computer Science 2025-02-11 Lu Liu , Yang Tang , Kexuan Zhang , Qiyu Sun

Understanding the latent causal factors of a dynamical system from visual observations is considered a crucial step towards agents reasoning in complex environments. In this paper, we propose CITRIS, a variational autoencoder framework that…

Machine Learning · Computer Science 2022-06-16 Phillip Lippe , Sara Magliacane , Sindy Löwe , Yuki M. Asano , Taco Cohen , Efstratios Gavves

Causal representation learning (CRL) has garnered increasing interest from the causal inference and artificial intelligence communities due to its potential to disentangle complex data-generating mechanism into causally interpretable latent…

Machine Learning · Statistics 2026-05-28 Hao Chen , Lin Liu , Yu Guang Wang

T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and malignancies. Modeling the distribution of TCR sequences is of…

Quantitative Methods · Quantitative Biology 2020-07-01 Giulio Isacchini , Zachary Sethna , Yuval Elhanati , Armita Nourmohammad , Aleksandra M. Walczak , Thierry Mora

Concept Factorization (CF) models have attracted widespread attention due to their excellent performance in data clustering. In recent years, many variant models based on CF have achieved great success in clustering by taking into account…

Machine Learning · Computer Science 2025-05-07 Zhengqin Yang , Di Wu , Jia Chen , Xin Luo

Causal representation learning (CRL) aims to identify the underlying latent variables from high-dimensional observations, even when variables are dependent with each other. We study this problem for latent variables that follow a…

Machine Learning · Statistics 2026-04-16 Danru Xu , Sébastien Lachapelle , Sara Magliacane

This paper presents a novel approach that leverages domain variability to learn representations that are conditionally invariant to unwanted variability or distractors. Our approach identifies both spurious and invariant latent features…

Machine Learning · Computer Science 2023-07-04 Hananeh Aliee , Ferdinand Kapl , Soroor Hediyeh-Zadeh , Fabian J. Theis

Causal representation learning promises to extend causal models to hidden causal variables from raw entangled measurements. However, most progress has focused on proving identifiability results in different settings, and we are not aware of…

Machine Learning · Computer Science 2025-02-04 Dingling Yao , Caroline Muller , Francesco Locatello

This thesis develops methods for causal inference and causal representation learning (CRL) in high-dimensional, time-varying data. The first contribution introduces the Causal Dynamic Variational Autoencoder (CDVAE), a model for estimating…

Machine Learning · Statistics 2025-12-05 Mouad EL Bouchattaoui

Causal representation learning seeks to extract high-level latent factors from low-level sensory data. Most existing methods rely on observational data and structural assumptions (e.g., conditional independence) to identify the latent…

Machine Learning · Statistics 2024-02-26 Kartik Ahuja , Divyat Mahajan , Yixin Wang , Yoshua Bengio

Navigating the complex landscape of single-cell transcriptomic data presents significant challenges. Central to this challenge is the identification of a meaningful representation of high-dimensional gene expression patterns that sheds…

Quantitative Methods · Quantitative Biology 2023-12-13 Mu Qiao

Causal representation learning seeks to recover latent factors that generate observational data through a mixing function. Needing assumptions on latent structures or relationships to achieve identifiability in general, prior works often…

Artificial Intelligence · Computer Science 2025-09-24 Kwonho Kim , Heejeong Nam , Inwoo Hwang , Sanghack Lee

Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

Machine Learning · Computer Science 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Imitation learning, which learns agent policy by mimicking expert demonstration, has shown promising results in many applications such as medical treatment regimes and self-driving vehicles. However, it remains a difficult task to interpret…

Machine Learning · Computer Science 2024-01-31 Tianxiang Zhao , Wenchao Yu , Suhang Wang , Lu Wang , Xiang Zhang , Yuncong Chen , Yanchi Liu , Wei Cheng , Haifeng Chen

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

Genomics · Quantitative Biology 2019-06-04 Tianle Ma , Aidong Zhang

Temporal knowledge graph reasoning (TKGR) is increasingly gaining attention for its ability to extrapolate new events from historical data, thereby enriching the inherently incomplete temporal knowledge graphs. Existing graph-based…

Machine Learning · Computer Science 2025-01-27 Jinze Sun , Yongpan Sheng , Lirong He , Yongbin Qin , Ming Liu , Tao Jia

With the resurgence of interest in neural networks, representation learning has re-emerged as a central focus in artificial intelligence. Representation learning refers to the discovery of useful encodings of data that make domain-relevant…

Machine Learning · Computer Science 2016-12-19 Karl Ridgeway

Physicochemically informed biological sequence generation has the potential to accelerate computer-aided cellular therapy, yet current models fail to \emph{jointly} ensure novelty, diversity, and biophysical plausibility when designing…

Computational Engineering, Finance, and Science · Computer Science 2025-10-08 Jiahao Ma , Hongzong Li , Ye-Fan Hu , Jian-Dong Huang

We introduce a framework for learning robust visual representations that generalize to new viewpoints, backgrounds, and scene contexts. Discriminative models often learn naturally occurring spurious correlations, which cause them to fail on…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Chengzhi Mao , Augustine Cha , Amogh Gupta , Hao Wang , Junfeng Yang , Carl Vondrick