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The geometry of blood vessels strongly affects hemostasis and thrombosis through red blood cell (RBC) dynamics and platelet margination. Growing platelet aggregates, in turn, reshape the local vessel wall topography, leading to a strongly…
In microfluidic systems, droplets undergo intricate deformations as they traverse flow-focusing junctions, posing a challenging task for accurate measurement, especially during short transit times. This study investigates the physical…
This work has explored interface evolution and pinch-off mechanism of the droplet formation in two-phase flow through cross-flow microfluidic device. The two-dimensional mathematical model equations have been solved using the finite element…
Understanding the physics of blood is challenging due to its nature as a suspension of soft particles and the fact that typical problems involve different scales. This is valid also for numerical investigations. In fact, many computational…
Blood accounts for 7-8% of total body weight, with an average adult containing 4.5 to 6 quarts. It delivers oxygen and nutrients to cells, removes waste products, supports immunity, and regulates body temperature. Comprising over 4,000…
We present a particle method for estimating the curvature of interfaces in volume-of-fluid simulations of multiphase flows. The method is well suited for under-resolved interfaces, and it is shown to be more accurate than the parabolic…
This study investigates the hydrodynamics of droplet formation in a T-shaped cylindrical microfluidic device using micro-PIV experiments and CFD simulations. Devices of 150 micro-m internal diameter were fabricated from PDMS via a…
A full characterization of the water flow past a silicon superhydrophobic surface with longitudinal micro-grooves enclosed in a microfluidic device is presented. Fluorescence microscopy images of the flow seeded with fluorescent passive…
In this work the computer modeling has been used to show that longer ligands allow biological cells (e.g., blood platelets) to withstand stronger flows after their adhesion to solid walls. Mechanistic model of polymer-mediated…
Background and Objective: The role of red blood cell dynamics is emphasised in certain cardiovascular diseases, and thus needs to be closely studied. A multiphase model of blood flow allows the resolution of locally varying density of red…
Adhesive interactions between white blood cells and the interior surface of the blood vessels they contact is important in inflammation and in the progression of heart disease. Parallel-plate microchannels have been useful in characterizing…
Hematotoxicity, drug-induced damage to the blood-forming system, is a frequent side effect of cytotoxic chemotherapy and poses a significant challenge in clinical practice due to its high inter-patient variability and limited…
The manipulation and control of microparticles through non-intrusive methods is pivotal in biomedical applications such as cell sorting and cell focusing. Although several experimental and numerical studies have been dedicated to single…
A new type of microfluidic system for biological cell manipulation, a CMOS/microfluidic hybrid, is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a…
We present an experimental micro-model of drying porous media, based on microfluidic cells made of arrays of pillars on a regular grid, and complement these experiments with a matching two-dimensional pore-network model of drying. Disorder,…
The efficient mixing of fluid samples in miniaturized total analysis systems is essential for numerous applications including biological screening assays, chemical extraction, polymerization, cell analysis, and protein folding. Miniaturized…
In this paper, we are concerned with the simulation of blood flow in microvascular networks and the surrounding tissue. To reduce the computational complexity of this issue, the network structures are modeled by a one-dimensional graph,…
Ischemia leading to heart attacks and strokes is the major cause of deaths in the world. Whether an occlusion occurs or not, depends on the ability of a growing thrombus to resist forces exerted on its structure. This manuscript provides…
Microfluidics and lab-on-a-chip technologies have made it possible to manipulate small volume liquids with unprecedented resolution, automation and integration. However, most current microfluidic systems still rely on bulky off-chip…
A microfluidic approach to probing the first normal stress difference from single-point pressure measurements in transient shear flows is presented. Using an original experimental design, we examine the near-zero-mean pulsatile flow of…