Long ligands reinforce biological adhesion under shear flow
Soft Condensed Matter
2018-04-18 v2 Biological Physics
Cell Behavior
Abstract
In this work the computer modeling has been used to show that longer ligands allow biological cells (e.g., blood platelets) to withstand stronger flows after their adhesion to solid walls. Mechanistic model of polymer-mediated ligand-receptor adhesion between a microparticle (cell) and a flat wall has been developed. Theoretical threshold between adherent and non-adherent regimes has been derived analytically and confirmed by simulations. These results lead to a deeper understanding of numerous biophysical processes, e.g., arterial thrombosis, and to the design of new biomimetic colloid-polymer systems.
Keywords
Cite
@article{arxiv.1803.06544,
title = {Long ligands reinforce biological adhesion under shear flow},
author = {Aleksey V. Belyaev},
journal= {arXiv preprint arXiv:1803.06544},
year = {2018}
}