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Markov state models (MSMs) have become a popular approach for investigating the conformational dynamics of proteins and other biomolecules. MSMs are typically built from numerous molecular dynamics simulations by dividing the sampled…

Biomolecules · Quantitative Biology 2015-06-12 Yuan Yao , Raymond Z. Cui , Gregory R. Bowman , Daniel Silva , Jian Sun , Xuhui Huang

In this paper we propose a new method to detect and classify coexisting solutions in nonlinear systems. We focus on mechanical and structural systems where we usually avoid multistability for safety and reliability. We want to be sure that…

Adaptation and Self-Organizing Systems · Physics 2016-02-12 P. Brzeski , M. Lazarek , T. Kapitaniak , J. Kurths , P. Perlikowski

Identifying parameters in a system of nonlinear, ordinary differential equations is vital for designing a robust controller. However, if the system is stochastic in its nature or if only noisy measurements are available, standard…

Systems and Control · Electrical Eng. & Systems 2022-10-10 Tobias Nagel , Marco F. Huber

The automated construction of coarse-grained models represents a pivotal component in computer simulation of physical systems and is a key enabler in various analysis and design tasks related to uncertainty quantification. Pertinent methods…

Machine Learning · Statistics 2019-09-11 Constantin Grigo , Phaedon-Stelios Koutsourelakis

Model uncertainty quantification is an essential component of effective data assimilation. Model errors associated with sub-grid scale processes are often represented through stochastic parameterizations of the unresolved process. Many…

Methodology · Statistics 2021-04-13 Sahani Pathiraja , Peter Jan van Leeuwen

Recent advances in deep learning frameworks have established valuable tools for analyzing the long-timescale behavior of complex systems such as proteins. Especially the inclusion of physical constraints, e.g. time-reversibility, was a…

Quantitative Methods · Quantitative Biology 2021-12-22 Andreas Mardt , Frank Noé

We extend classical coarse-grained entropy, commonly used in many branches of physics, to the quantum realm. We find two coarse-grainings, one using measurements of local particle numbers and then total energy, and the second using local…

Quantum Physics · Physics 2019-01-17 Dominik Šafránek , J. M. Deutsch , Anthony Aguirre

Despite the increasing visibility of fine-grained recognition in our field, "fine-grained'' has thus far lacked a precise definition. In this work, building upon clustering theory, we pursue a framework for measuring dataset granularity. We…

Computer Vision and Pattern Recognition · Computer Science 2019-12-24 Yin Cui , Zeqi Gu , Dhruv Mahajan , Laurens van der Maaten , Serge Belongie , Ser-Nam Lim

We propose a measure of macroscopic coherence based on the degree of disturbance caused by a coarse-grained measurement. Based on our measure, we point out that recently proposed criteria of macroscopic coherence may lead to inconsistent…

Quantum Physics · Physics 2017-05-09 Hyukjoon Kwon , Chae-Yeun Park , Kok Chuan Tan , Hyunseok Jeong

We construct explicit examples of one-dimensional driven diffusive systems for two and three species of interacting particles, defined by asymmetric dynamical rules which do not obey detailed balance, but whose nonequilibrium…

Statistical Mechanics · Physics 2007-05-23 J. M. Luck , C. Godreche

Linear causal models are important tools for modeling causal dependencies and yet in practice, only a subset of the variables can be observed. In this paper, we examine the parameter identifiability of these models by investigating whether…

Machine Learning · Computer Science 2025-02-11 Xinshuai Dong , Ignavier Ng , Biwei Huang , Yuewen Sun , Songyao Jin , Roberto Legaspi , Peter Spirtes , Kun Zhang

Precision control of a quantum system requires accurate determination of the effective system Hamiltonian. We develop a method for estimating the Hamiltonian parameters for some unknown two-state system and providing uncertainty bounds on…

We tackle the problem of system identification, where we select inputs, observe the corresponding outputs from the true system, and optimize the parameters of our model to best fit the data. We propose a practical and computationally…

Systems and Control · Electrical Eng. & Systems 2025-10-02 Alexandros E. Tzikas , Mykel J. Kochenderfer

Self-testing is a device-independent method that usually amounts to show that the maximal quantum violation of a Bell's inequality certifies a unique quantum state, up to some symmetries inherent to the device-independent framework. In this…

Quantum Physics · Physics 2021-12-15 Irénée Frérot , Antonio Acín

In present paper we suggest a new universal approach to study complex systems by microscopic, mesoscopic and macroscopic methods. We discuss new possibilities of extracting information on nonstationarity, unsteadiness and non-Markovity of…

Disordered Systems and Neural Networks · Physics 2007-05-23 Renat M. Yulmetyev , Anatolii V. Mokshin , Peter Hänggi

We present a coarse-graining method applicable to dry scalar active matter with motility regulation. Our approach, based on a multiscale perturbative expansion of the backward Kolmogorov equation, does not rely on any specific microscopic…

Statistical Mechanics · Physics 2026-04-13 Alberto Dinelli , Pietro Luigi Muzzeddu

We study the problem of learning clusters of partially observed linear dynamical systems from multiple input-output trajectories. This setting is particularly relevant when there are limited observations (e.g., short trajectories) from…

Systems and Control · Electrical Eng. & Systems 2025-07-24 Maryann Rui , Munther A. Dahleh

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde

Coarse-grained (CG) modeling simplifies molecular systems by mapping groups of atoms into representative units. However, traditional CG approaches rely on fixed mapping rules, which limit their ability to handle diverse chemical systems and…

Computational Physics · Physics 2025-09-26 Zhixuan Zhong , Linbo Ma , Jian Jiang

Coarse-grained models are a core computational tool in theoretical chemistry and biophysics. A judicious choice of a coarse-grained model can yield physical insight by isolating the essential degrees of freedom that dictate the…

Statistical Mechanics · Physics 2023-04-12 Shriram Chennakesavalu , David J. Toomer , Grant M. Rotskoff
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