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We study a susceptible-infected-recovered (SIR) epidemic model on a network of $n$ interacting subpopulations. We analyze the transient and asymptotic behavior of the infection dynamics in each node of the network. In contrast to the…

Dynamical Systems · Mathematics 2024-03-18 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani

Neural field models with transmission delay may be cast as abstract delay differential equations (DDE). The theory of dual semigroups (also called sun-star calculus) provides a natural framework for the analysis of a broad class of delay…

Dynamical Systems · Mathematics 2017-12-11 Stephan A. van Gils , Sebastiaan G. Janssens , Yuri A. Kuznetsov , Sid Visser

The probability distribution describing the state of a Stochastic Reaction Network evolves according to the Chemical Master Equation (CME). It is common to estimated its solution using Monte Carlo methods such as the Stochastic Simulation…

Quantitative Methods · Quantitative Biology 2015-06-18 Benjamin Hepp , Ankit Gupta , Mustafa Khammash

In this paper we describe a combined combinatorial/numerical approach to studying equilibria and bifurcations in network models arising in Systems Biology. ODE models of the dynamics suffer from high dimensional parameters which presents a…

Dynamical Systems · Mathematics 2024-11-28 Shane Kepley , Konstantin Mischaikow , Elena Queirolo

In this paper we investigate the bifurcation structure of the triangular SKT model in the weak competition regime and of the corresponding fast-reaction system in 1D and 2D domains via numerical continuation methods. We show that the…

Analysis of PDEs · Mathematics 2019-11-06 Christian Kuehn , Cinzia Soresina

We study a diffusive SIS epidemic model with the mass-action transmission mechanism and show, under appropriate assumptions on the parameters, the existence of multiple endemic equilibria (EE). Our results answer some open questions on…

Analysis of PDEs · Mathematics 2023-11-07 Keoni Castellano , Rachidi B. Salako

This paper analyses of a stochastic model of a chemical reaction network with three types of chemical species ${\cal R}$, ${\cal M}$ and ${\cal U}$ that interact to transform a flow of external resources, the chemical species ${\cal Q}$, to…

Probability · Mathematics 2025-12-01 Vincent Fromion , Philippe Robert , Jana Zaherddine

We introduce the Graph Mixture Density Networks, a new family of machine learning models that can fit multimodal output distributions conditioned on graphs of arbitrary topology. By combining ideas from mixture models and graph…

Machine Learning · Computer Science 2021-06-28 Federico Errica , Davide Bacciu , Alessio Micheli

A feature often observed in epidemiological networks is significant heterogeneity in degree. A popular modelling approach to this has been to consider large populations with highly heterogeneous discrete contact rates. This paper defines an…

Populations and Evolution · Quantitative Biology 2014-03-13 Thomas House

The exploration of epidemic dynamics on dynamically evolving ("adaptive") networks poses nontrivial challenges to the modeler, such as the determination of a small number of informative statistics of the detailed network state (that is, a…

Quantitative Methods · Quantitative Biology 2015-07-07 Assimakis A. Kattis , Alexander Holiday , Ana-Andreea Stoica , Ioannis G. Kevrekidis

A system of two cubic reaction-diffusion equations for two independent gene frequencies arising in population dynamics is studied. Depending on values of coefficients, all possible Lie and $Q$-conditional (nonclassical) symmetries are…

Exactly Solvable and Integrable Systems · Physics 2026-03-27 Philip Broadbridge , Roman Cherniha , Vasyl' Davydovych , Ian Marquette

Optimal control of interdependent epidemics spreading over complex networks is a critical issue. We first establish a framework to capture the coupling between two epidemics, and then analyze the system's equilibrium states by categorizing…

Systems and Control · Computer Science 2017-10-19 Juntao Chen , Rui Zhang , Quanyan Zhu

Across many disciplines, chemical reaction networks (CRNs) are an established population model defined as a system of coupled nonlinear ordinary differential equations. In many applications, for example, in systems biology and epidemiology,…

Systems and Control · Electrical Eng. & Systems 2023-01-23 Kim G. Larsen , Daniele Toller , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

Dynamics on networks is considered from the perspective of Markov stochastic processes. We partially describe the state of the system through network motifs and infer any missing data using the available information. This versatile approach…

We address the challenge of identifying all real positive steady states in chemical reaction networks (CRNs) governed by mass-action kinetics. Traditional numerical methods often require specific initial guesses and may fail to find all the…

Molecular Networks · Quantitative Biology 2025-09-29 Paola Ferrari , Sara Sommariva , Michele Piana , Federico Benvenuto , Matteo Varbaro

The spatial structure of populations is a key element in the understanding of the large scale spreading of epidemics. Motivated by the recent empirical evidence on the heterogeneous properties of transportation and commuting patterns among…

Populations and Evolution · Quantitative Biology 2008-03-19 Vittoria Colizza , Alessandro Vespignani

Considerable attention has been paid, in recent years, to the use of networks in modeling complex real-world systems. Among the many dynamical processes involving networks, propagation processes -- in which final state can be obtained by…

Populations and Evolution · Quantitative Biology 2017-10-06 Antoine Allard , Pierre-André Noël , Louis J. Dubé , Babak Pourbohloul

The epidemic threshold is probably the most studied quantity in the modelling of epidemics on networks. For a large class of networks and dynamics the epidemic threshold is well studied and understood. However, it is less so for clustered…

Physics and Society · Physics 2018-06-19 Rosanna C. Barnard , Luc Berthouze , Péter L. Simon , István Z. Kiss

We calculate epidemic thresholds and investigate the dynamics of a disease in a networked metapopulation model. To study the specific role of mobility levels and network geometry, we utilize the SIR-Network model and consider a range of…

Physics and Society · Physics 2023-08-07 Haridas K. Das , Lucas M. Stolerman

The development of chemical reaction models aids understanding and prediction in areas ranging from biology to electrochemistry and combustion. A systematic approach to building reaction network models uses observational data not only to…

Computational Engineering, Finance, and Science · Computer Science 2019-01-23 Nikhil Galagali , Youssef M. Marzouk