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In this work, we consider the problem of estimating summary statistics to characterise biochemical reaction networks of interest. Such networks are often described using the framework of the Chemical Master Equation (CME). For…

Quantitative Methods · Quantitative Biology 2018-11-27 Christopher Lester , Christian A. Yates , Ruth E. Baker

Stochastic evolution of Chemical Reactions Networks (CRNs) over time is usually analysed through solving the Chemical Master Equation (CME) or performing extensive simulations. Analysing stochasticity is often needed, particularly when some…

Logic in Computer Science · Computer Science 2015-09-11 Luca Laurenti , Luca Cardelli , Marta Kwiatkowska

Drug resistance and strong contacts actually play crucial roles in epidemic spread in complex systems. Nevertheless, neither theoretical model or methodology is proposed to address this. We thus consider an edge-based epidemic spread model…

Physics and Society · Physics 2017-09-13 Peng-Bi Cui , Lei Gao , Wei Wang

The stochastic dynamics of biochemical networks are usually modelled with the chemical master equation (CME). The stationary distributions of CMEs are seldom solvable analytically, and numerical methods typically produce estimates with…

Probability · Mathematics 2019-10-30 Juan Kuntz , Philipp Thomas , Guy-Bart Stan , Mauricio Barahona

Biochemical reactions with oscillatory behavior play an essential role in synthetic biology at the microscopic scale. Although a robust stability theory for deterministic chemical oscillators in the macroscopic limit exists, the dynamical…

Molecular Networks · Quantitative Biology 2019-02-27 Pedro H. Constantino , Yiannis N. Kaznessis

Real epidemic spreading networks often composed of several kinds of networks interconnected with each other, and the interrelated networks have the different topologies and epidemic dynamics. Moreover, most human diseases are derived from…

Physics and Society · Physics 2017-06-21 Zhongpu Xu , Xinchu Fu

We investigate the SIR epidemic on a dynamic inhomogeneous Erd\H{o}s-R\'enyi random graph, in which vertices are of one of $k$ types and in which edges appear and disappear independently of each other. We establish a functional law of large…

Probability · Mathematics 2024-04-22 Yuanfei Huang , Adrian Röllin

Traditional epidemic detection algorithms make decisions using only local information. We propose a novel approach that explicitly models spatial information fusion from several metapopulations. Our method also takes into account…

Computation · Statistics 2015-09-15 Michael Ludkovski , Katherine Shatskikh

Biochemical mechanisms with mass action kinetics are often modeled by systems of polynomial differential equations (DE). Determining directly if the DE system has multiple equilibria (multistationarity) is difficult for realistic systems,…

Molecular Networks · Quantitative Biology 2014-11-12 Carsten Conradi , Maya Mincheva

Moment-closure methods are popular tools to simplify the mathematical analysis of stochastic models defined on networks, in which high dimensional joint distributions are approximated (often by some heuristic argument) as functions of lower…

Data Analysis, Statistics and Probability · Physics 2011-05-25 Tim Rogers

Many real world networks are characterized by adaptive changes in their topology depending on the dynamic state of their nodes. Here we study epidemic dynamics in an adaptive network, where susceptibles are able to avoid contact with…

Populations and Evolution · Quantitative Biology 2007-05-23 Thilo Gross , Carlos Dommar D'Lima , Bernd Blasius

In this paper, the equivariant degree theory is used to analyze the occurrence of the Hopf bifurcation under effectively verifiable mild conditions. We combine the abstract result with standard interval polynomial techniques based on…

Dynamical Systems · Mathematics 2015-07-31 E. Hooton , Z. Balanov , W. Krawcewicz , D. Rachinskii

Critical transitions occur in a wide variety of applications including mathematical biology, climate change, human physiology and economics. Therefore it is highly desirable to find early-warning signs. We show that it is possible to…

Dynamical Systems · Mathematics 2015-03-17 Christian Kuehn

The objective of this paper is to study the dynamical behaviour systematically of an ecological system with Beddington-DeAngelis functional response which avoids the criticism occurred in the case of ratio-dependent functional response at…

Dynamical Systems · Mathematics 2015-01-21 Sahabuddin Sarwardi , Md. Reduanur Mandal , Nurul Huda Gazi

In this paper we consider a model of a nutrient-prey-predator system in a chemostat with general functional responses, using the input concentration of nutrient as the bifurcation parameter. We study the changes in the existence of isolated…

Dynamical Systems · Mathematics 2019-11-20 Mary Ballyk , Ibrahim Jawarneh , Ross Staffeldt

Network theory has often disregarded many-body relationships, solely focusing on pairwise interactions: neglecting them, however, can lead to misleading representations of complex systems. Hypergraphs represent a suitable framework for…

Social and Information Networks · Computer Science 2025-07-16 Fabio Saracco , Giovanni Petri , Renaud Lambiotte , Tiziano Squartini

A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…

Optimization and Control · Mathematics 2017-03-09 Sebastian Anita , Vincenzo Capasso

The concept of the limiting step is extended to the asymptotology of multiscale reaction networks. Complete theory for linear networks with well separated reaction rate constants is developed. We present algorithms for explicit…

Chemical Physics · Physics 2010-06-15 A. N. Gorban , O. Radulescu , A. Y. Zinovyev

We consider an opinion dynamics model coupled with an environmental dynamics. Based on a forward invariance argument, we can simplify the analysis of the asymptotic behavior to the case when all the opinions in the social network are…

Systems and Control · Electrical Eng. & Systems 2025-04-07 Anthony Couthures , Anastasia Bizyaeva , Vineeth S. Varma , Alessio Franci , Irinel-Constantin Morarescu

Cycles, which can be found in many different kinds of networks, make the problems more intractable, especially when dealing with dynamical processes on networks. On the contrary, tree networks in which no cycle exists, are simplifications…

Physics and Society · Physics 2021-04-07 Wenjun Zhang , Wei Li , Weibing Deng
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