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Stochastic reaction networks are mathematical models with a wide range of applications in biochemistry, ecology, and epidemiology, and are often complex to analyze. Except for some special cases, it is generally difficult to predict how the…

Probability · Mathematics 2026-04-02 Daniele Cappelletti , Giulio Cuniberti , Paola Siri

We show that spectral fluctuation of interaction matrices of yeast a core protein interaction network and a metabolic network follows the description of the Gaussian orthogonal ensemble (GOE) of random matrix theory (RMT). Furthermore, we…

Molecular Networks · Quantitative Biology 2009-11-11 Feng Luo , Jianxin Zhong , Yunfeng Yang , Richard H. Scheuermann , Jizhong Zhou

In living cells, chemical reactions form a complex network. Complicated dynamics arising from such networks are the origins of biological functions. We propose a novel mathematical method to analyze bifurcation behaviors of a reaction…

Molecular Networks · Quantitative Biology 2018-08-08 Takashi Okada , Je-Chiang Tsai , Atsushi Mochizuki

Recent years have seen a large amount of interest in epidemics on networks as a way of representing the complex structure of contacts capable of spreading infections through the modern human population. The configuration model is a popular…

Populations and Evolution · Quantitative Biology 2017-01-23 Frank Ball , Thomas House

In chemical reaction network theory, ordinary differential equations are used to model the temporal change of chemical species concentration. As the functional form of these ordinary differential equations systems is derived from an…

Molecular Networks · Quantitative Biology 2025-02-27 Anna C. M. Thöni , William E. Robinson , Yoram Bachrach , Wilhelm T. S. Huck , Tal Kachman

We study the network reconstruction problem for an epidemic reaction-diffusion. These models are an extension of deterministic, compartmental models to a graph setting, where the reactions within the nodes are coupled by a diffusion. We…

Chaotic Dynamics · Physics 2021-09-24 Louis-Brahim Beaufort , Pierre-Yves Massé , Antonin Reboulet , Laurent Oudre

The aim of this paper is to study the steady states of the mathematical models with delay kernels which describe pathogen-immune dynamics of many kinds of infectious diseases. In the study of mathematical models of infectious diseases it is…

Dynamical Systems · Mathematics 2007-05-23 M. Neamtu , L. Buliga , F. R. Horhat , D. Opris , A. T. Ceausu

Systems of ODEs coupled with the topology of a closed ring are common models in biology, robotics, electrical engineering, and many other areas of science. When the component systems and couplings are identical, the system has a cyclic…

Dynamical Systems · Mathematics 2024-03-26 Ian Stewart

Complex contagion models that involve contagion along higher-order structures, such as simplicial complexes and hypergraphs, yield new classes of mean-field models. Interestingly, the differential equations arising from many such models…

Physics and Society · Physics 2025-09-24 István Z. Kiss , Christian Bick , Péter L. Simon

Biochemical networks are used in computational biology, to model the static and dynamical details of systems involved in cell signaling, metabolism, and regulation of gene expression. Parametric and structural uncertainty, as well as…

Molecular Networks · Quantitative Biology 2014-10-15 Ovidiu Radulescu , Alexander N. Gorban , Andrei Zinovyev , Vincent Noel

This study examines the behavior of solutions in a multi-patch epidemic model that includes a saturation incidence mechanism. When the fatality rate due to the disease is not null, our findings show that the solutions of the model tend to…

Populations and Evolution · Quantitative Biology 2024-09-19 Yawo Ezunkpe , Cynthia T. Nnolum , Rachidi B. Salako , Shuwen Xue

We present new algorithms for detecting the emergence of a community in large networks from sequential observations. The networks are modeled using Erdos-Renyi random graphs with edges forming between nodes in the community with higher…

Machine Learning · Statistics 2015-06-22 David Marangoni-Simonsen , Yao Xie

We study the Suscectible-Infected-Recovered-Susceptible (SIRS) epidemic model on deterministic networks. For connected but otherwise general interaction patterns and heterogeneous recovery and loss-of-immunity rates, we identify a…

Systems and Control · Electrical Eng. & Systems 2026-04-24 Giulia Gatti , Giacomo Como

In this paper we study bifurcations in mass-action networks with two chemical species and reactant complexes of molecularity no more than two. We refer to these as planar, quadratic networks as they give rise to (at most) quadratic…

Dynamical Systems · Mathematics 2024-10-22 Murad Banaji , Balázs Boros , Josef Hofbauer

In the work two ways of evolutionary interpretation of entropy model for correspondence matrix calculation are proposed. Both approaches based on the stochastic chemical kinetic evolution under the detailed balance condition. The first…

Optimization and Control · Mathematics 2020-03-30 Alexander Gasnikov , Evgenia Gasnikova , Mikhail Mendel , Ksenya Chepurchenko

We are concerned with random ordinary differential equations (RODEs). Our main question of interest is how uncertainties in system parameters propagate through the possibly highly nonlinear dynamical system and affect the system's…

Dynamical Systems · Mathematics 2021-08-30 Christian Kuehn , Kerstin Lux

A reaction network is a chemical system involving multiple reactions and chemical species. Stochastic models of such networks treat the system as a continuous time Markov chain on the number of molecules of each species with reactions as…

Probability · Mathematics 2007-05-23 Karen Ball , Thomas G. Kurtz , Lea Popovic , Greg Rempala

Reaction networks have become a major modelling framework in the biological sciences from epidemiology and population biology to genetics and cellular biology. In recent years, much progress has been made on stochastic reaction networks…

Probability · Mathematics 2025-08-14 Linard Hoessly , Carsten Wiuf , Panqiu Xia

Chemical Reaction Networks (CRNs) provide a useful abstraction of molecular interaction networks in which molecular structures as well as mass conservation principles are abstracted away to focus on the main dynamical properties of the…

Molecular Networks · Quantitative Biology 2020-07-31 Elisabeth Degrand , François Fages , Sylvain Soliman

Systems biology uses large networks of biochemical reactions to model the functioning of biological cells from the molecular to the cellular scale. The dynamics of dissipative reaction networks with many well separated time scales can be…

Molecular Networks · Quantitative Biology 2013-05-28 Vincent Noel , Dima Grigoriev , Sergei Vakulenko , Ovidiu Radulescu