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In an era where the volume of data drives the effectiveness of self-supervised learning, the specificity and clarity of data semantics play a crucial role in model training. Addressing this, we introduce HYPerbolic Entailment filtering…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Wonjae Kim , Sanghyuk Chun , Taekyung Kim , Dongyoon Han , Sangdoo Yun

Recently, model merging methods have demonstrated powerful strengths in combining abilities on various tasks from multiple Large Language Models (LLMs). While previous model merging methods mainly focus on merging homogeneous models with…

Computation and Language · Computer Science 2026-04-23 Yiyang Du , Xiaochen Wang , Chi Chen , Jiabo Ye , Yiru Wang , Peng Li , Ming Yan , Ji Zhang , Fei Huang , Zhifang Sui , Maosong Sun , Yang Liu

The widespread adoption of Large Language Models (LLMs) has exponentially increased the demand for efficient serving systems. With growing requests and context lengths, key-value (KV)-related operations, including attention computation and…

Hardware Architecture · Computer Science 2026-02-13 Lian Liu , Shixin Zhao , Yutian Zhou , Yintao He , Mengdi Wang , Yinhe Han , Ying Wang

Medical anomaly detection has emerged as a promising solution to challenges in data availability and labeling constraints. Traditional methods extract features from different layers of pre-trained networks in Euclidean space; however,…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Alvaro Gonzalez-Jimenez , Simone Lionetti , Ludovic Amruthalingam , Philippe Gottfrois , Fabian Gröger , Marc Pouly , Alexander A. Navarini

We present a unique, multitask dataset comprising 143 drug and drug candidate molecules, each evaluated on in vitro, parallel artificial-membrane permeability assays (PAMPA) using six different model membranes. Using this resource, we…

Machine Learning · Computer Science 2026-05-04 Andrs Formanek , Anna Vincze , Richrd Bicsak , Yves Moreau , Gyorgy T. Balogh , Adam Arany

Deep learning models show promise in digital pathology, but their opaque decision-making processes limit trust and clinical adoption. To address this challenge, we present HIPPO, an explainable AI method for analyzing weakly-supervised…

Tissues and Organs · Quantitative Biology 2025-12-10 Jakub R. Kaczmarzyk , Chanwoo Kim , Soham Gadgil , Deepika Savant , Zhen Zhao , Joel H. Saltz , Su-In Lee , Peter K. Koo

Antibody design remains a critical challenge in therapeutic and diagnostic development, particularly for complex antigens with diverse binding interfaces. Current computational methods face two main limitations: (1) capturing geometric…

Machine Learning · Computer Science 2025-06-27 Jiameng Chen , Xiantao Cai , Jia Wu , Wenbin Hu

A novel framework has recently been proposed for designing the molecular structure of chemical compounds with a desired chemical property, where design of novel drugs is an important topic in bioinformatics and chemo-informatics. The…

In this work, we have developed a multiscale computational algorithm to couple finite element method with an open source molecular dynamics code --- the Large scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) --- to perform…

Soft Condensed Matter · Physics 2019-09-17 Takahiro Murashima , Shingo Urata , Shaofan Li

Metamaterials exhibit materials response deviation from conventional elasticity. This phenomenon is captured by the generalized elasticity as a result of extending the theory at the expense of introducing additional parameters. These…

Computational Engineering, Finance, and Science · Computer Science 2021-06-10 Bilen Emek Abali , Emilio Barchiesi

High Bandwidth Memory with Processing-in-Memory (HBM-PIM) offers an opportunity to reduce data movement by executing computation directly inside memory, but current commercial platforms expose limited instruction sets and require…

Hardware Architecture · Computer Science 2026-05-01 Emanuele Venieri , Simone Manoni , Alberto Florian , Jaehyun Park , Kyomin Sohn , Andrea Bartolini

In this study, linear matrix inequality (LMI) approaches and multiobjective (MO) evolutionary algorithms are integrated to design controllers. An MO matrix inequality problem (MOMIP) is first defined. A hybrid MO differential evolution…

Systems and Control · Electrical Eng. & Systems 2026-01-16 Wei-Yu Chiu

For their excellent stiffness-to-weight characteristics, triply periodic minimal surfaces (TPMS) are widely adopted in architected materials. However, their geometric regularity often leads to elastic anisotropy, limiting their…

Computational Physics · Physics 2025-05-21 Minwoo Park , Junheui Jo , Seunghwa Ryu

Molecular representation learning, a cornerstone for downstream tasks like molecular captioning and molecular property prediction, heavily relies on Graph Neural Networks (GNN). However, GNN suffers from the over-smoothing problem, where…

Machine Learning · Computer Science 2025-08-13 Zihang Shao , Wentao Lei , Lei Wang , Wencai Ye , Li Liu

Multimodal Large Language Models (MLLMs) have experienced significant advancements recently. Nevertheless, challenges persist in the accurate recognition and comprehension of intricate details within high-resolution images. Despite being…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Haogeng Liu , Quanzeng You , Xiaotian Han , Yiqi Wang , Bohan Zhai , Yongfei Liu , Yunzhe Tao , Huaibo Huang , Ran He , Hongxia Yang

This paper contributes to interpretable machine learning via visual knowledge discovery in parallel coordinates. The concepts of hypercubes and hyper-blocks are used as easily understandable by end-users in the visual form in parallel…

Machine Learning · Computer Science 2021-07-06 Boris Kovalerchuk , Dustin Hayes

Unsupervised Domain Adaptation (UDA) is essential for deploying medical segmentation models across diverse clinical environments. Existing methods are fundamentally limited, suffering from semantically unaware feature alignment that results…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Linkuan Zhou , Yinghao Xia , Yufei Shen , Xiangyu Li , Wenjie Du , Cong Cong , Leyi Wei , Ran Su , Qiangguo Jin

This paper explores the use of optimization to design multifunctional metamaterials, and proposes a methodology for constructing a design envelope of potential properties. A thermal-mechanical metamaterial, proposed by Ai and Gao (2017), is…

Computational Engineering, Finance, and Science · Computer Science 2020-04-29 Ewan Fong , Sadik L. Omairey , Peter D. Dunning

Predictive Business Process Monitoring (PBPM) aims to forecast future outcomes of ongoing business processes. However, existing methods often lack flexibility to handle real-world challenges such as simultaneous events, class imbalance, and…

Machine Learning · Computer Science 2025-08-06 Fang Wang , Paolo Ceravolo , Ernesto Damiani

Recent shifts in global health priorities have positioned Population Health Management (PHM) as a central area of focus. However, optimizing PHM strategies presents several challenges: managing high-dimensional patient covariates, tracking…

Optimization and Control · Mathematics 2026-04-10 Daniel Adelman , Alba V Olivares-Nadal , Miaolan Xie
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