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While large language models (LLMs), such as GPT-3, appear to be robust and general, their reasoning ability is not at a level to compete with the best models trained for specific natural language reasoning problems. In this study, we…

Computation and Language · Computer Science 2023-07-18 Zhun Yang , Adam Ishay , Joohyung Lee

Advancements in artificial intelligence for molecular science are necessitating a paradigm shift from purely data-driven predictions to knowledge-guided computational reasoning. Existing molecular models are predominantly proprietary,…

Machine Learning · Computer Science 2026-03-16 Pengfei Liu , Shuang Ge , Jun Tao , Zhixiang Ren

Large Language Models, such as Generative Pre-trained Transformer 3 (aka. GPT-3), have been developed to understand language through the analysis of extensive text data, allowing them to identify patterns and connections between words.…

Computation and Language · Computer Science 2023-10-03 Baphumelele Masikisiki , Vukosi Marivate , Yvette Hlope

Random Number Generation Tasks (RNGTs) are used in psychology for examining how humans generate sequences devoid of predictable patterns. By adapting an existing human RNGT for an LLM-compatible environment, this preliminary study tests…

Artificial Intelligence · Computer Science 2024-08-21 Rachel M. Harrison

Large Language Models (LLMs) have the unique capability to understand and generate human-like text from input queries. When fine-tuned, these models show enhanced performance on domain-specific queries. OpenAI highlights the process of…

Computation and Language · Computer Science 2024-07-02 Scott Barnett , Zac Brannelly , Stefanus Kurniawan , Sheng Wong

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Unlocking deep and interpretable biological reasoning from complex genomic data remains a major AI challenge limiting scientific progress. While current DNA foundation models excel at representing sequences, they struggle with multi-step…

Deep learning is catalyzing a scientific revolution fueled by big data, accessible toolkits, and powerful computational resources, impacting many fields including protein structural modeling. Protein structural modeling, such as predicting…

Biomolecules · Quantitative Biology 2020-07-17 Wenhao Gao , Sai Pooja Mahajan , Jeremias Sulam , Jeffrey J. Gray

Recently, there has been a surge in interest in NLP driven by ChatGPT. ChatGPT, a transformer-based generative language model of substantial scale, exhibits versatility in performing various tasks based on natural language. Nevertheless,…

Computation and Language · Computer Science 2023-09-11 Xiaocheng Yang , Yik-Cheung Tam

While Large Language Models (LLMs) have demonstrated exceptional multitasking abilities, fine-tuning these models on downstream, domain-specific datasets is often necessary to yield superior performance on test sets compared to their…

Computation and Language · Computer Science 2024-03-15 Haoran Yang , Yumeng Zhang , Jiaqi Xu , Hongyuan Lu , Pheng Ann Heng , Wai Lam

The recent surge of generative AI has been fueled by the generative power of diffusion probabilistic models and the scalable capabilities of large language models. Despite their potential, it remains elusive whether diffusion language…

Computation and Language · Computer Science 2025-02-25 Jiasheng Ye , Zaixiang Zheng , Yu Bao , Lihua Qian , Quanquan Gu

In recent years, the detection of AI-generated text has become a critical area of research due to concerns about academic integrity, misinformation, and ethical AI deployment. This paper presents COT Fine-tuned, a novel framework for…

Computation and Language · Computer Science 2025-04-24 Shifali Agrahari , Sanasam Ranbir Singh

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Large language models (LLM) have achieved impressive progress across a broad range of general-purpose tasks, but their effectiveness in chemistry remains limited due to scarce domain-specific datasets and the demand for precise symbolic and…

Dialogue-based language models mark a huge milestone in the field of artificial intelligence, by their impressive ability to interact with users, as well as a series of challenging tasks prompted by customized instructions. However, the…

Artificial Intelligence · Computer Science 2023-04-26 Rui Hao , Linmei Hu , Weijian Qi , Qingliu Wu , Yirui Zhang , Liqiang Nie

Bayesian adaptive clinical trials offer a flexible and efficient alternative to traditional fixed-design trials, but their implementation is often hindered by the complexity of Bayesian computations and the need for advanced statistical…

Applications · Statistics 2025-07-04 Krishna Padmanabhan , Danny Baker

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

The rapid progression in artificial intelligence has facilitated the emergence of large language models like ChatGPT, offering potential applications extending into specialized engineering modeling, especially physics-based building energy…

Human-Computer Interaction · Computer Science 2024-11-18 Liang Zhang , Zhelun Chen , Vitaly Ford

Large language models (LLMs) such as ChatGPT and GPT-4 have demonstrated impressive capabilities in various generative tasks. However, their performance is often hampered by limitations in accessing and leveraging long-term memory, leading…

Artificial Intelligence · Computer Science 2024-07-16 Zhongsheng Wang , Jiamou Liu , Qiming Bao , Hongfei Rong , Jingfeng Zhang

Large language models (LLMs) are currently at the forefront of intertwining AI systems with human communication and everyday life. Therefore, it is of great importance to evaluate their emerging abilities. In this study, we show that LLMs…

Computation and Language · Computer Science 2023-10-10 Thilo Hagendorff , Sarah Fabi , Michal Kosinski