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Related papers: Chaining thoughts and LLMs to learn DNA structural…

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We report a flexible language-model based deep learning strategy, applied here to solve complex forward and inverse problems in protein modeling, based on an attention neural network that integrates transformer and graph convolutional…

Biomolecules · Quantitative Biology 2023-10-20 Markus J. Buehler

AI and generative AI tools, including chatbots like ChatGPT that rely on large language models (LLMs), have burst onto the scene this year, creating incredible opportunities to increase work productivity and improve our lives. Statisticians…

Computation and Language · Computer Science 2024-03-27 Mark Glickman , Yi Zhang

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

With the surge of ChatGPT,the use of large models has significantly increased,rapidly rising to prominence across the industry and sweeping across the internet. This article is a comprehensive review of fine-tuning methods for large models.…

Machine Learning · Computer Science 2024-04-16 Benjue Weng

The paper aims to fulfil three main functions: (1) to serve as an introduction for the physics education community to the functioning of Large Language Models (LLMs), (2) to present a series of illustrative examples demonstrating how…

Physics Education · Physics 2024-01-31 Giulia Polverini , Bor Gregorcic

This paper explores the enhancement of small language models through strategic dataset augmentation via ChatGPT-3.5-Turbo, in the domain of Natural Language Inference (NLI). By employing knowledge distillation-based techniques and synthetic…

Computation and Language · Computer Science 2024-09-20 Tom Pieper , Mohamad Ballout , Ulf Krumnack , Gunther Heidemann , Kai-Uwe Kühnberger

Chain of thought (CoT) fine-tuning aims to endow large language models (LLMs) with reasoning capabilities by training them on curated reasoning traces. It leverages both supervised and reinforced fine-tuning to cultivate human-like…

Computation and Language · Computer Science 2026-03-24 Xiaoshu Chen , Sihang Zhou , Ke Liang , Duanyang Yuan , Haoyuan Chen , Xiaoyu Sun , Lingyuan Meng , Xinwang Liu

Chain-of-thought prompting has demonstrated great success in facilitating the reasoning abilities of large language models. In this work, we explore how these enhanced reasoning abilities can be exploited to improve the robustness of large…

Computation and Language · Computer Science 2025-04-30 Wenxiao Wang , Parsa Hosseini , Soheil Feizi

This paper examines the application of ChatGPT, a large language model (LLM), for question-and-answer (Q&A) tasks in the highly specialized field of nuclear data. The primary focus is on evaluating ChatGPT's performance on a curated test…

Computation and Language · Computer Science 2024-09-04 Muhammad Anwar , Mischa de Costa , Issam Hammad , Daniel Lau

AI tasks encompass a wide range of domains and fields. While numerous AI models have been designed for specific tasks and applications, they often require considerable human efforts in finding the right model architecture, optimization…

Computation and Language · Computer Science 2023-05-05 Shujian Zhang , Chengyue Gong , Lemeng Wu , Xingchao Liu , Mingyuan Zhou

Large Language Models (LLMs) demonstrate remarkable performance on a variety of natural language understanding (NLU) tasks, primarily due to their in-context learning ability. This ability could be applied to building babylike models, i.e.…

Computation and Language · Computer Science 2023-10-24 Zheyu Zhang , Han Yang , Bolei Ma , David Rügamer , Ercong Nie

Continual pre-training (CPT) has been an important approach for adapting language models to specific domains or tasks. To make the CPT approach more traceable, this paper presents a technical report for continually pre-training Llama-3…

Large language models are powerful systems that excel at many tasks, ranging from translation to mathematical reasoning. Yet, at the same time, these models often show unhuman-like characteristics. In the present paper, we address this gap…

Computation and Language · Computer Science 2023-06-08 Marcel Binz , Eric Schulz

Discovering new materials better suited to specific purposes is an important issue in improving the quality of human life. Here, a neural network that creates molecules that meet some desired conditions based on a deep understanding of…

Machine Learning · Computer Science 2022-02-15 Hyunseung Kim , Jonggeol Na , Won Bo Lee

With the advent of large language models (LLMs), in both the open source and proprietary domains, attention is turning to how to exploit such artificial intelligence (AI) systems in assisting complex scientific tasks, such as material…

Human-Computer Interaction · Computer Science 2024-01-26 Yongtao Liu , Marti Checa , Rama K. Vasudevan

The capabilities of AI for biomedicine span a wide spectrum, from the atomic level, where it solves partial differential equations for quantum systems, to the molecular level, predicting chemical or protein structures, and further extending…

Computation and Language · Computer Science 2024-03-26 Zhenyu Bi , Sajib Acharjee Dip , Daniel Hajialigol , Sindhura Kommu , Hanwen Liu , Meng Lu , Xuan Wang

Large language models (LLMs) such as those embedded in 'chatbots' are accelerating and democratizing research by providing comprehensible information and expertise from many different fields. However, these models may also confer easy…

Computers and Society · Computer Science 2023-06-07 Emily H. Soice , Rafael Rocha , Kimberlee Cordova , Michael Specter , Kevin M. Esvelt

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li

Modern language model-based AI systems are remarkably powerful, yet their capabilities remain fundamentally capped by their human creators in three key ways. First, although a model's weights can be updated via fine-tuning, acquiring new…

Artificial Intelligence · Computer Science 2026-03-20 Zitong Yang

This paper introduces ClimateGPT, a model family of domain-specific large language models that synthesize interdisciplinary research on climate change. We trained two 7B models from scratch on a science-oriented dataset of 300B tokens. For…