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We developed a low-cost, high-throughput microbiome profiling method that uses combinatorial sequence tags attached to PCR primers that amplify the rRNA V6 region. Amplified PCR products are sequenced using an Illumina paired-end protocol…

Background: The short reads output by first- and second-generation DNA sequencing instruments cannot completely reconstruct microbial chromosomes. Therefore, most genomes have been left unfinished due to the significant resources required…

DNA sequencing is the process of determining the exact order of the nucleotide bases of an individual's genome in order to catalogue sequence variation and understand its biological implications. Whole-genome sequencing techniques produce…

Data Structures and Algorithms · Computer Science 2015-09-18 Ljiljana Brankovic , Costas S. Iliopoulos , Ritu Kundu , Manal Mohamed , Solon P. Pissis , Fatima Vayani

The realization of single-molecule electronic devices, in which a nanometer-scale molecule is connected to macroscopic leads, requires the reproducible production of highly ordered nanoscale gaps in which a molecule of interest is…

Mesoscale and Nanoscale Physics · Physics 2009-05-08 Sujit S. Datta , Douglas R. Strachan , A. T. Charlie Johnson

Overcoming the influence of noise and imperfections in quantum devices is one of the main challenges for viable quantum applications. In this article, we present different protocols, which we denote as "superposed quantum error mitigation",…

Spins associated to solid-state colour centers are a promising platform for investigating quantum computation and quantum networks. Recent experiments have demonstrated multi-qubit quantum processors, optical interconnects, and basic…

Nanopore genome sequencing is the key to enabling personalized medicine, global food security, and virus surveillance. The state-of-the-art base-callers adopt deep neural networks (DNNs) to translate electrical signals generated by nanopore…

Hardware Architecture · Computer Science 2020-08-10 Qian Lou , Sarath Janga , Lei Jiang

Nanomechanical computers promise a greatly improved energetic efficiency compared to their electrical counterparts. However, progress towards this goal is hindered by a lack of modular components, such as logic gates or transistors, and…

Emerging Technologies · Computer Science 2019-10-09 Marc Serra-Garcia

Purpose Nanopore-based molecular sensing and measurement, specifically Deoxyribonucleic acid (DNA) sequencing, is advancing at a fast pace. Some embodiments have matured from coarse particle counters to enabling full human genome assembly.…

Instrumentation and Detectors · Physics 2021-10-06 Mehdi Habibi , Yunus Dawji , Ebrahim Ghafar-Zadeh , Sebastian Magierowski

High-fidelity logical \emph{T}-gate realization constitutes a core prerequisite for large-scale fault-tolerant quantum computing. However, conventional magic state distillation requires massive physical qubit overhead across successive…

Quantum Physics · Physics 2026-05-04 Cheng-Yun Ding , Li-Hua Zhang , Jian Zhou

A code clone is a pair of code fragments, within or between software systems that are similar. Since code clones often negatively impact the maintainability of a software system, several code clone detection techniques and tools have been…

Software Engineering · Computer Science 2020-05-05 Golam Mostaeen , Banani Roy , Chanchal Roy , Kevin Schneider , Jeffrey Svajlenko

Repeating a gate sequence multiple times amplifies systematic errors coherently, making it a useful tool for characterizing quantum gates. However, the precision of such an approach is limited by low-frequency noises, while its efficiency…

The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Motivation: New long read sequencers promise to transform sequencing and genome assembly by producing reads tens of kilobases long. However their high error rate significantly complicates assembly and requires expensive correction steps to…

Genomics · Quantitative Biology 2017-07-18 Antoine Recanati , Thomas Brüls , Alexandre d'Aspremont

This paper proposes the use of Eukaryotic cells, namely astrocytes, to develop logic gates. The logic gates are achieved by manipulating the threshold of Ca$^{2+}$ ion flows between the cells, based on the input signals. Through wet-lab…

Most near-term quantum information processing devices will not be capable of implementing quantum error correction and the associated logical quantum gate set. Instead, quantum circuits will be implemented directly using the physical native…

High-quality two-qubit gate operations are crucial for scalable quantum information processing. Often, the gate fidelity is compromised when the system becomes more integrated. Therefore, a low-error-rate, easy-to-scale two-qubit gate…

Quantum Physics · Physics 2020-12-24 Yuan Xu , Ji Chu , Jiahao Yuan , Jiawei Qiu , Yuxuan Zhou , Libo Zhang , Xinsheng Tan , Yang Yu , Song Liu , Jian Li , Fei Yan , Dapeng Yu

Amplitude Amplification offers a provable speedup for search problems, which is leveraged in combinatorial optimization by Grover Adaptive Search (GAS). The protocol demands deep circuits that are challenging with regards to NISQ…

Quantum Physics · Physics 2026-04-08 Laurin Demmler , Maximilian Hess

Genetic Algorithms (GAs) are used to solve search and optimization problems in which an optimal solution can be found using an iterative process with probabilistic and non-deterministic transitions. However, depending on the problem's…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-01-23 Matheus F. Torquato , Marcelo A. C. Fernandes

We consider error-correcting coding for deoxyribonucleic acid (DNA)-based storage using nanopore sequencing. We model the DNA storage channel as a sampling noise channel where the input data is chunked into $M$ short DNA strands, which are…

Information Theory · Computer Science 2024-06-21 Lorenz Welter , Roman Sokolovskii , Thomas Heinis , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat