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A phase-sensitive microscopy technique is proposed and demonstrated that employs the momentum correlations inherent in spontaneous parametric down-conversion. One photon from a correlated pair is focused onto a microscopic target while the…

Quantum Physics · Physics 2023-01-23 Hazel Hodgson , Yingwen Zhang , Duncan England , Benjamin Sussman

X-ray near field holography has proven to be a powerful 2D and 3D imaging technique with applications ranging from biomedical research to material sciences. To reconstruct meaningful and quantitative images from the measurement intensities,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-04 Jens Lucht , Leon M. Lohse , Thorsten Hohage , Tim Salditt

High-resolution non-invasive 3D study of intact spine and spinal cord morphology on the level of complex vascular and neuronal organization is a crucial issue for the development of treatments for the injuries and pathologies of central…

Medical Physics · Physics 2017-03-01 I. Bukreeva , V. Asadchikov , A. Buzmakov , V. Grigoryev , A. Bravin , A. Cedola

Off-axis X-ray holography is a lensless imaging technique that allows unambiguous retrieval of an object's exit-wave function with high fidelity. It has been used with great success to study nanoscale phenomena and spatio-temporal dynamics…

Scanning transmission electron microscopy (STEM) has been extensively used for imaging complex materials down to atomic resolution. The most commonly employed STEM modality, annular dark-field imaging, produces easily-interpretable…

Atomically controlled crystal growth of thin films has established foundations of nanotechnology aimed at the development of advanced functional devices. Crystallization under non-equilibrium conditions allows engineering of new materials…

X-ray interferometry provides valuable information in terms of attenuation, small-angle scatter, and differential phase contrast. This multi-modal contrast can aid in many clinical applications, such as lung diseases and breast cancer.…

Optics · Physics 2026-03-12 Murtuza S. Taqi , Joyoni Dey , Hunter C. Meyer

Usually, lesions are not isolated but are associated with the surrounding tissues. For example, the growth of a tumour can depend on or infiltrate into the surrounding tissues. Due to the pathological nature of the lesions, it is…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Lin Wang , Xiufen Ye , Donghao Zhang , Wanji He , Lie Ju , Yi Luo , Huan Luo , Xin Wang , Wei Feng , Kaimin Song , Xin Zhao , Zongyuan Ge

The ability to gain insights into the 3D properties of artificial or biological systems is often critical. However, 3D structures are difficult to retrieve at low dose and with extremely fast processing, as most techniques are based on…

Image and Video Processing · Electrical Eng. & Systems 2019-09-11 J. Duarte , R. Cassin , J. Huijts , M. Kholodtsova , B. Iwan , M. Kovacev , M. Fajardo , F. Fortuna , L. Delbecq , W. Boutu , H. Merdji

Phase-contrast microscopy converts the optical phase introduced by transparent, unlabeled specimens into modulation in the intensity image. Modern phase imaging techniques are capable of quantifying phase shift at each point in the field of…

In this work, a general theoretical framework is presented to explain the formation of the phase signal in an X-ray microscope integrated with a grating interferometer, which simultaneously enables the high spatial resolution imaging and…

Optics · Physics 2022-09-28 Jiecheng Yang , Yongshuai Ge , Dong Liang , Hairong Zheng

Imaging of microvasculature is primarily performed with X-ray contrast agents, owing to the wide availability of absorption-contrast laboratory source microCT compared to phase contrast capable devices. Standard commercial contrast agents…

Tissues and Organs · Quantitative Biology 2023-01-18 Willy Kuo , Ngoc An Le , Bernhard Spingler , Georg Schulz , Bert Müller , Vartan Kurtcuoglu

X-ray phase-contrast imaging has the potential to improve image contrast with lower dose by probing an object's refractive properties as well as its absorptive properties. To reconstruct a phase-contrast image from a raw dataset, a phase…

Medical Physics · Physics 2025-08-19 Giavanna Jadick , Patrick La Rivière

Detection of phase variations across optically transparent samples is often a difficult task. We propose and demonstrate a compact, lightweight and low cost quantitative phase contrast imager. Light diffracted from a pinhole is incident on…

This paper presents an approach for understanding the soft tissue behavior in surface contact with a probe scanning the tissue. The application domain is confocal microlaparoscopy, mostly used for imaging the outer surface of the organs in…

Robotics · Computer Science 2018-04-16 M. Erden , B. Rosa , J. Szewczyk , G. Morel

We develop an integrated system of holographic optical trapping and multimodal nonlinear microscopy and perform simultaneous three-dimensional optical manipulation and non-invasive structural imaging of composite soft-matter systems. We…

Soft Condensed Matter · Physics 2015-05-20 Rahul P. Trivedi , Taewoo Lee , Kris A. Bertness , Ivan I. Smalyukh

We integrate a small and portable medical x-ray device with mechanical testing equipment to enable in-situ, non-invasive measurements of a granular material's response to mechanical loading. We employ an orthopedic C-arm as the x-ray source…

The Fourier inversion of phased coherent diffraction patterns offers images without the resolution and depth-of-focus limitations of lens-based tomographic systems. We report on our recent experimental images inverted using recent…

The development of three-dimensional (3D) non-destructive X-ray characterization techniques in home laboratories is essential for enabling many more researchers to perform 3D characterization daily, overcoming the limitations imposed by…

In this article, we demonstrate the viability of highly monochromatic full-field X-ray absorption near edge structure based tomography using a laboratory-scale Johann-type X-ray absorption spectrometer based on a conventional X-ray tube…

Instrumentation and Detectors · Physics 2022-10-04 Ari-Pekka Honkanen , Simo Huotari