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We demonstrate experimentally that optical phase conjugation can be used to focus light through strongly scattering media even when far less than a photon per optical degree of freedom is detected. We found that the best achievable…

Optics · Physics 2017-03-08 M. Jang , C. Yang , I. M. Vellekoop

Differential phase contrast microscopy (DPC) provides high-resolution quantitative phase distribution of thin transparent samples under multi-axis asymmetric illuminations. Typically, illumination in DPC microscopic systems is designed with…

Optics · Physics 2019-03-27 Yao Fan , Jiasong Sun , Qian Chen , Xiangpeng Pan , Lei Tian , Chao Zuo

Fluorescence microscopy has revolutionized biomedical research over the past three decades. Its high molecular specificity and unrivaled single molecule level sensitivity have enabled breakthroughs in a variety of research fields. For in…

Optics · Physics 2012-03-21 Meng Cui , Ke Si , Reto Fiolka

This publication presents an investigation of the performance of different analytical electron ptychography methods for low-dose imaging. In particular, benchmarking is performed for two model-objects, monolayer MoS$_2$ and apoferritin, by…

Applied Physics · Physics 2025-05-20 Hoelen L. Lalandec Robert , Max Leo Leidl , Knut Müller-Caspary , Jo Verbeeck

X-ray diffusive dark-field imaging, which allows spatially unresolved microstructure to be mapped across a sample, is an increasingly popular tool in an array of settings. Here, we present a new algorithm for phase and dark-field computed…

Medical Physics · Physics 2023-12-07 T. A. Leatham , D. M. Paganin , K. S. Morgan

Nonlinear optical generation from a crystalline material can reveal the symmetries of both its lattice structure and underlying ordered electronic phases and can therefore be exploited as a complementary technique to diffraction based…

Strongly Correlated Electrons · Physics 2014-11-04 D. H. Torchinsky , H. Chu , T. Qi , G. Cao , D. Hsieh

Propagation-based X-ray phase contrast enables nanoscale imaging of biological tissue by probing not only the attenuation, but also the real part of the refractive index of the sample. Since only intensities of diffracted waves can be…

Numerical Analysis · Mathematics 2017-09-11 Simon Maretzke , Thorsten Hohage

Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Volodymyr Sydorskyi , Igor Krashenyi , Oleksii Yakubenko

Phase contrast imaging seeks to reconstruct the complex refractive index of an unknown sample from scattering intensities, measured for example under illumination with coherent X-rays. By incorporating refraction, this method yields…

Numerical Analysis · Mathematics 2018-11-06 Simon Maretzke

X-ray interaction with matter is an energy-dependent process that is contingent on the atomic structure of the constituent material elements. The most advanced models to capture this relationship currently rely on Monte Carlo (MC)…

Machine Learning · Computer Science 2023-07-11 Raziye Kubra Kumrular , Thomas Blumensath

We develop and thoroughly test a stress-controlled, parallel plates shear cell that can be coupled to an optical microscope or a small angle light scattering setup, for simultaneous investigation of the rheological properties and the…

Soft Condensed Matter · Physics 2017-01-04 S. Aime , L. Ramos , J. -M. Fromental , G. Prévot , R. Jelinek , L. Cipelletti

Electron microscopy is a powerful tool for visualizing the shapes of sub-nanometer objects. However, contrast is not in proportional to density distribution, and therefore achieving a quantitative understanding of specimens is not…

Instrumentation and Detectors · Physics 2020-05-14 Masato Tomita , Yukinori Nagatani , Kazuyoshi Murata , Atsushi Momose

Histological visualizations are critical to clinical disease management and are fundamental to biological understanding. However, current approaches that rely on bright-field microscopy require extensive tissue preparation prior to imaging.…

We describe a method to compute photon-matter interaction and atomic dynamics with X-ray lasers using a hybrid code based on classical molecular dynamics and collisional-radiative calculations. The forces between the atoms are dynamically…

Superconducting microcircuits and metamaterials are promising candidates for use in new generation cryogenic electronics. Their functionality is largely justified by the macroscopic distribution of electromagnetic fields in arranged unit…

Superconductivity · Physics 2022-02-16 A. A. Leha , A. P. Zhuravel , A. Karpov , A. V. Lukashenko , A. V. Ustinov

This paper introduces the methodology proposed by our group to model the biological soft tissues deformations and to couple these models with Computer-Assisted Surgical (CAS) applications. After designing CAS protocols that mainly focused…

X-ray microspectroscopic techniques are essential for studying morphological and chemical changes in materials, providing high-resolution structural and spectroscopic information. However, its practical data analysis for reliably retrieving…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Ting Wang , Xiaotong Wu , Jizhou Li , Chao Wang

The microscopic distribution of strain and stress plays a crucial role for the performance, safety, and lifetime of components in aeronautics, automotive and critical infrastructure [1]. While non-destructive methods for measuring the…

Materials Science · Physics 2025-04-09 Peter Modregger , James. A. D. Ball , Felix Wittwer , Ahmar Khaliq , Jonathan Wright

The 3D structure of light scattering from dark-field illuminated live 3T3 cells marked with 40 nm gold nanomarkers is explored. For this purpose, we use a high resolution holographic microscope combining the off-axis heterodyne geometry and…

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