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Recent innovations in x-ray technology (namely phase-based and energy-resolved imaging) offer unprecedented opportunities for material discrimination, however they are often used in isolation or in limited combinations. Here we show that…

X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale…

Plasma Physics · Physics 2019-06-26 J. Wenz , S. Schleede , K. Khrennikov , M. Bech , P. Thibault , M. Heigoldt , F. Pfeiffer , S. Karsch

When x-rays penetrate soft matter, their phase changes more rapidly than their amplitude. In- terference effects visible with high brightness sources creates higher contrast, edge enhanced images. When the object is piecewise smooth (made…

Imaging of nanoscale magnetic textures within extended material systems is of critical importance both to fundamental research and technological applications. Whilst high resolution magnetic imaging of thin nanoscale samples is…

Material decomposition in X-ray imaging uses the energy-dependence of attenuation to virtually decompose an object into specific constituent materials. X-ray phase contrast imaging is a developing technique that can enhance image contrast…

We reported the usage of grating-based X-ray phase-contrast imaging in nondestructive testing of grating imperfections. It was found that electroplating flaws could be easily detected by conventional absorption signal, and in particular, we…

Instrumentation and Detectors · Physics 2018-04-27 Shenghao Wang , Can Zhang

X-ray dark-field imaging creates a representation of the sample where contrast is generated by subresolution features within the volume under inspection. These are detected by a local measurement of the radiation field's angular…

New lensless diffractive X-ray technic for micro-scale imaging of biological tissue is based on quantitative phase retrieval schemes. By incorporating refraction, this method yields improved contrast compared to purely absorption-based…

Numerical Analysis · Mathematics 2018-03-28 Victor Palamodov

Articular cartilage is a musculoskeletal soft tissue renowned for its unique mechanical properties. Understanding both its hierarchical structure and the interplay between its constituents could shed light on the mechanical competence of…

Medical Physics · Physics 2025-10-17 Simone Fantoni , Luca Brombal , Paolo Cardarelli , Fabio Baruffaldi

Purpose: Grating-based X-ray phase-contrast imaging is a promising modality increasing the soft tissue contrast in medical imaging. In this work, the signature of lung tissue in X-ray grating-based physe-contrast imaging is investigated.…

Virtual histology is an emerging field in biomedicine that enables three-dimensional tissue visualization using X-ray micro-computed tomography. However, the method still lacks the specificity of conventional histology, in which parts of…

X-ray phase-contrast imaging enhances soft tissue visualization by leveraging the phase shift of X-rays passing through materials. It permits to minimize radiation exposure due to high contrast, as well as high resolution imaging limited by…

Optics · Physics 2024-03-13 Emilie Pietersoone , Jean Michel Létang , Simon Rit , Max Langer

Quantum imaging employs the nonclassical correlation of photons to break through the noise limitation of classical imaging, realizing high sensitivity, high SNR imaging and multifunctional image processing. To enhance the flexibility and…

Fabrication of X-ray gratings has surged in the last two decades thanks to their vast employment in X-ray Phase Contrast Imaging, an imaging technique able to boost X-ray sensitivity to detect otherwise invisible details. These high aspect…

Many lung diseases require detailed visualisation for accurate diagnosis and treatment. High-resolution computed tomography (CT) is the gold-standard technique for non-invasive lung disease detection, but it presents a risk to the patient…

The problem of optimization of propagation-based phase-contrast imaging setups is considered in the case of projection X-ray imaging and three-dimensional tomography with phase retrieval. For two-dimensional imaging, a simple model for a…

Medical Physics · Physics 2026-03-03 T. E. Gureyev , D. M. Paganin , H. M. Quiney

Three-dimensional phase contrast imaging of multiply-scattering samples in X-ray and electron microscopy is extremely challenging, due to small numerical apertures, the unavailability of wavefront shaping optics, and the highly nonlinear…

Computational Physics · Physics 2021-06-02 Philipp M Pelz , Hamish G Brown , Jim Ciston , Scott D Findlay , Yaqian Zhang , Mary Scott , Colin Ophus

Like many other advanced imaging methods, x-ray phase contrast imaging and tomography require mathematical inversion of the observed data to obtain real-space information. While an accurate forward model describing the generally nonlinear…

Numerical Analysis · Mathematics 2016-04-07 Simon Maretzke , Matthias Bartels , Martin Krenkel , Tim Salditt , Thorsten Hohage

Electron tomography is a technique used in both materials science and structural biology to image features well below optical resolution limit. In this work, we present a new algorithm for reconstructing the three-dimensional(3D)…

Signal Processing · Electrical Eng. & Systems 2018-07-12 David Ren , Michael Chen , Laura Waller , Colin Ophus

Low dose, high contrast x-ray imaging is of general interest in medical diagnostic applications. X-ray Mach-Zehnder interferometers using collimated synchrotron beams demonstrate the highest levels of phase contrast under a given exposure…