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Imaging mass spectrometry (IMS) has transformed proteomics by providing an avenue for collecting spatially distributed molecular data. Mass spectrometry data acquired with matrix assisted laser desorption ionization (MALDI) IMS consist of…

Applications · Statistics 2016-02-05 Lyron J. Winderbaum , Inge Koch , Ove J. R. Gustafsson , Stephan Meding , Peter Hoffmann

In several application domains, high-dimensional observations are collected and then analysed in search for naturally occurring data clusters which might provide further insights about the nature of the problem. In this paper we describe a…

Machine Learning · Statistics 2012-03-07 Brian McWilliams , Giovanni Montana

Recent hardware acceleration advances have enabled powerful specialized accelerators for finite element computations, spiking neural network inference, and sparse tensor operations. However, existing approaches face fundamental limitations:…

Hardware Architecture · Computer Science 2026-01-09 Chuanzhen Wang , Leo Zhang , Eric Liu

Frequency comb spectroscopy has significantly advanced molecular spectroscopy across scientific research and diverse applications. Among its key performance metrics especially for time-resolved studies, sensitivity and measurement speed are…

Objective: Acute mountain sickness (AMS) is the most prevalent altitude illness, affecting unacclimatized individuals ascending above 2,500 m and potentially escalating to life threatening cerebral or pulmonary edema. Conventional machine…

Symbolic Computation · Computer Science 2026-05-19 Abu Masum , Mehran Moghadam , M. Hassan Najafi , Bige Unluturk , Ulkuhan Guler , Beth A. Beidleman , Sercan Aygun

Identifying relationships between molecular variations and their clinical presentations has been challenged by the heterogeneous causes of a disease. It is imperative to unveil the relationship between the high dimensional molecular…

Methodology · Statistics 2021-09-02 Wennan Chang , Changlin Wan , Yong Zang , Chi Zhang , Sha Cao

Genome sequencing projects are rapidly increasing the number of high-dimensional protein sequence datasets. Clustering a high-dimensional protein sequence dataset using traditional machine learning approaches poses many challenges. Many…

Quantitative Methods · Quantitative Biology 2022-04-27 Preeti Jha , Aruna Tiwari , Neha Bharill , Milind Ratnaparkhe , Om Prakash Patel , Nilagiri Harshith , Mukkamalla Mounika , Neha Nagendra

Super-resolution imaging techniques have largely improved our capabilities to visualize nanometric structures in biological systems. Their application further enables one to potentially quantitate relevant parameters to determine the…

Biological Physics · Physics 2019-12-18 Tina Kosǔta , Marta Cullell-Dalmau , Francesca Cella Zanacchi , Carlo Manzo

Spectral clustering is a celebrated algorithm that partitions objects based on pairwise similarity information. While this approach has been successfully applied to a variety of domains, it comes with limitations. The reason is that there…

Statistics Theory · Mathematics 2018-05-24 Kwangjun Ahn , Kangwook Lee , Changho Suh

The emerging brain-inspired computing paradigm known as hyperdimensional computing (HDC) has been proven to provide a lightweight learning framework for various cognitive tasks compared to the widely used deep learning-based approaches.…

Emerging Technologies · Computer Science 2021-06-23 Geethan Karunaratne , Manuel Le Gallo , Michael Hersche , Giovanni Cherubini , Luca Benini , Abu Sebastian , Abbas Rahimi

Hyperspectral (HS) imaging presents itself as a non-contact, non-ionizing and non-invasive technique, proven to be suitable for medical diagnosis. However, the volume of information contained in these images makes difficult providing the…

Smart manufacturing requires on-device intelligence that meets strict latency and energy budgets. HyperDimensional Computing (HDC) offers a lightweight alternative by encoding data as high-dimensional hypervectors and computing with simple…

Machine Learning · Computer Science 2025-10-01 Fardin Jalil Piran , Anandkumar Patel , Rajiv Malhotra , Farhad Imani

The dissection of hyperspectral images into intrinsic components through hyperspectral intrinsic image decomposition (HIID) enhances the interpretability of hyperspectral data, providing a foundation for more accurate classification…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Zhiqiang Gong , Xian Zhou , Wen Yao , Xiaohu Zheng , Ping Zhong

Feature selection methods are widely used to address the high computational overheads and curse of dimensionality in classifying high-dimensional data. Most conventional feature selection methods focus on handling homogeneous features,…

Machine Learning · Computer Science 2021-11-17 Xuyang Yan , Mrinmoy Sarkar , Biniam Gebru , Shabnam Nazmi , Abdollah Homaifar

High-dimensional clustering analysis is a challenging problem in statistics and machine learning, with broad applications such as the analysis of microarray data and RNA-seq data. In this paper, we propose a new clustering procedure called…

Methodology · Statistics 2022-10-31 Tianqi Liu , Yu Lu , Biqing Zhu , Hongyu Zhao

Hyperspectral imaging (HSI) holds great potential for healthcare due to its rich spectral information. However, acquiring HSI data remains costly and technically demanding. Hyperspectral image reconstruction offers a practical solution by…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Yufei Wen , Yuting Zhang , Jingdan Kang , Hao Ren , Weibin Cheng , Jintai Chen , Kaishun Wu

Mass spectrometry-based proteomics has become the tool of choice for identifying and quantifying the proteome of an organism. Though recent years have seen a tremendous improvement in instrument performance and the computational tools used,…

Persistent homology has been devised as a promising tool for the topological simplification of complex data. However, it is computationally intractable for large data sets. In this work, we introduce multiresolution persistent homology for…

Biomolecules · Quantitative Biology 2015-04-02 Kelin Xia , Zhixiong Zhao , Guo-Wei Wei

Essential protein plays a crucial role in the process of cell life. The identification of essential proteins can not only promote the development of drug target technology, but also contribute to the mechanism of biological evolution. There…

Molecular Networks · Quantitative Biology 2020-05-20 Pengli Lu , JingJuan Yu

Spectral clustering is a popular method for community detection in network graphs: starting from a matrix representation of the graph, the nodes are clustered on a low dimensional projection obtained from a truncated spectral decomposition…

Machine Learning · Statistics 2022-08-10 Francesco Sanna Passino , Nicholas A. Heard , Patrick Rubin-Delanchy