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Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that…
Background: Adolescence is a critical period of brain maturation and heightened vulnerability to cognitive and mental health disorders. Sleep plays a vital role in neurodevelopment, yet the mechanisms linking insufficient sleep to adverse…
Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key evidence from neuroimaging data for pathological commonness remains unrevealed. To explore this hypothesis,…
Evidence suggests that disruptions of the posteromedial cortex (PMC) and posteromedial corticothalamic connectivity contribute to disorders of consciousness (DOCs). While most previous studies treated the PMC as a whole, this structure is…
Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and their mechanisms are unclear. We computed grey matter…
The electroencephalographic (EEG) data intracerebrally recorded from 20 epileptic humans with different brain origins of focal epilepsies or types of seizures, ages and sexes are investigated (nearly 700 million data). Multi channel…
Prevention of secondary brain injury is a core aim of neurocritical care, with Spreading Depolarizations (SDs) recognized as a significant independent cause. SDs are typically monitored through invasive, high-frequency electrocorticography…
The extraction of brain functioning features is a crucial step in the definition of brain-computer interfaces (BCIs). In the last decade, functional connectivity (FC) estimators have been increasingly explored based on their ability to…
Neural biomarkers that can classify or predict disease are of broad interest to the neurological and psychiatric communities. Such biomarkers can be informative of disease state or treatment efficacy, even before there are changes in…
Alzheimer's disease (AD) causes alterations of brain network structure and function. The latter consists of connectivity changes between oscillatory processes at different frequency channels. We proposed a multi-layer network approach to…
Motion-related artifacts are inevitable in Magnetic Resonance Imaging (MRI) and can bias automated neuroanatomical metrics such as cortical thickness. These biases can interfere with statistical analysis which is a major concern as motion…
Executive function, also known as executive control, is a multifaceted construct encompassing several cognitive abilities, including working memory, attention, impulse control, and cognitive flexibility. To accurately measure executive…
Complex network analysis has an increasing relevance in the study of neurological disorders, enhancing the knowledge of brain's structural and functional organization. Network structure and efficiency reveal different brain states along…
Schizophrenia is a chronic neuropsychiatric disorder that causes distinct structural alterations within the brain. We hypothesize that deep learning applied to a structural neuroimaging dataset could detect disease-related alteration and…
Parkinsons Disease (PD) is a neurodegenerative disorder resulting in motor deficits due to advancing degeneration of dopaminergic neurons. PD patients report experiencing tremor, rigidity, visual impairment, bradykinesia, and several…
The present review presents multiple techniques in which ocular assessments may serve as a noninvasive approach for the early diagnoses of various cognitive and psychiatric disorders, such as Alzheimer's disease (AD), autism spectrum…
We propose a model of brain atrophy as a function of high-dimensional genetic information and low dimensional covariates such as gender, age, APOE gene, and disease status. A nonparametric single-index Bayesian model of high dimension is…
Mental disorders represent critical public health challenges as they are leading contributors to the global burden of disease and intensely influence social and financial welfare of individuals. The present comprehensive review concentrate…
Brain cognitive functions arise through the coordinated activity of several brain regions, which actually form complex dynamical systems operating at multiple frequencies. These systems often consist of interacting subsystems, whose…
IntroductionThe free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic…