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The brain-age gap is one of the most investigated risk markers for brain changes across disorders. While the field is progressing towards large-scale models, recently incorporating uncertainty estimates, no model to date provides the…

Manic episodes of bipolar disorder can lead to uncritical behaviour and delusional psychosis, often with destructive consequences for those affected and their surroundings. Early detection and intervention of a manic episode are crucial to…

Cerebral microbleeds, markers of brain damage from vascular and amyloid pathologies, are linked to cognitive decline in aging, but their role in Alzheimer's disease (AD) onset and progression remains unclear. This study aimed to explore…

Neurons and Cognition · Quantitative Biology 2024-10-18 Saima Rathore , Jatin Chaudhary , Boning Tong , Selen Bozkurt

The cerebral cortex performs higher-order brain functions and is thus implicated in a range of cognitive disorders. Current analysis of cortical variation is typically performed by fitting surface mesh models to inner and outer cortical…

Image and Video Processing · Electrical Eng. & Systems 2020-10-06 Samuel Budd , Prachi Patkee , Ana Baburamani , Mary Rutherford , Emma C. Robinson , Bernhard Kainz

Bimodal stimulation, combining cochlear implant (CI) and acoustic input from the opposite ear, typically enhances speech perception but varies due to factors like temporal mismatch. Previously, we used cortical auditory evoked potentials…

Neurons and Cognition · Quantitative Biology 2025-01-29 Hanna Dolhopiatenko , Waldo Nogueira

Neurodegenerative diseases and traumatic brain injuries (TBI) are among the main causes of cognitive dysfunction in humans. Both manifestations exhibit the extensive presence of focal axonal swellings (FAS). FAS compromises the information…

Neurons and Cognition · Quantitative Biology 2016-09-27 Melanie Weber , Pedro D. Maia , J. Nathan Kutz

Brain parenchymal fraction (BPF) has been used as a surrogate measure of global brain atrophy, and as a biomarker of brain reserve in studies evaluating clinical outcomes after brain injury. Total brain volume at the time of injury has…

Neurons and Cognition · Quantitative Biology 2024-03-20 Kenda Alhadid , Robert W. Regenhardt , Natalia S. Rost , Markus D. Schirmer

For long it has been known that specific patterns of folding are necessary for an optimally functioning brain. For instance, lissencephaly and polymicrogyria can lead to severe mental retardation, short life expectancy, epileptic seizures,…

Biological Physics · Physics 2020-04-03 Lucas da Costa Campos , Raphael Hornung , Gerhard Gompper , Jens Elgeti , Svenja Caspers

Electroencephalography (EEG)-based attention disorder research seeks to understand brain activity patterns associated with attention. Previous studies have mainly focused on identifying brain regions involved in cognitive processes or…

Neurons and Cognition · Quantitative Biology 2024-10-15 Debashis Das Chakladar , Foteini Simistira Liwicki , Rajkumar Saini

Objective: We aimed to determine the relationship between day-to-day sleep efficiency variability and cognitive function among older adults using accelerometer data and three cognitive tests. Methods: Older adults aged 65+ with 5 days of…

Applications · Statistics 2023-11-07 Collin Sakal , Tingyou Li , Juan Li , Xinyue Li

Most studies indicate that intelligence (g) is positively correlated with cortical thickness. However, the interindividual variability of cortical thickness has not been taken into account. In this study, we aimed to identify the…

Neurons and Cognition · Quantitative Biology 2019-11-25 Qi Zhao , Lingli Zhang , Chun Shen , Jie Zhang , Jianfeng Feng

Hippocampal atrophy in Alzheimer's disease (AD) is asymmetric and spatially inhomogeneous. While extensive work has been done on volume and shape analysis of atrophy of the hippocampus in AD, less attention has been given to hippocampal…

Image and Video Processing · Electrical Eng. & Systems 2024-09-20 Shen Zhu , Ifrah Zawar , Jaideep Kapur , P. Thomas Fletcher

Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. In this paper, we leverage recent advances in…

First-episode schizophrenia (FES) results in abnormality of brain connectivity at different levels. Despite some successful findings on functional and structural connectivity of FES, relatively few studies have been focused on morphological…

Neurons and Cognition · Quantitative Biology 2022-12-27 Mowen Yin , Weikai Huang , Zhichao Liang , Quanying Liu , Xiaoying Tang

Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be…

Bipolar disorder is a mental health disorder that causes mood swings that range from depression to mania. Diagnosis of bipolar disorder is usually done based on patient interviews, and reports obtained from the caregivers of the patients.…

Computation and Language · Computer Science 2021-12-20 Pınar Baki

In Alzheimer's disease (AD), the progressive atrophy leads to aberrant network reconfigurations both at structural and functional levels. In such network reorganization, the core and peripheral nodes appear to be crucial for the prediction…

Brain-computer interfaces (BCIs) constitute a promising tool for communication and control. However, mastering non-invasive closed-loop systems remains a learned skill that is difficult to develop for a non-negligible proportion of users.…

Intracortical US imaging extends B-mode imaging into bone using a dedicated image reconstruction algorithm that corrects for refraction at the bone-soft tissue interfaces. It has shown promising results in a few healthy, predominantly young…

Medical Physics · Physics 2025-02-14 Amadou S. Dia , Guillaume Renaud , Christine Chappard , Quentin Grimal

The deficit of executive functioning was found to be associated with attention deficit hyperactivity disorder (ADHD) in general and its subtypes. One of the important functions of central executive is the ability simultaneously coordinate…

Neurons and Cognition · Quantitative Biology 2011-01-11 Ketevan Inasaridze , Vera Bzhalava