Neural correlates of episodic memory in the Memento cohort
Abstract
IntroductionThe free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.MethodsWe investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose--positron emission tomography evaluations.ResultsEncoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions.DiscussionThe neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.
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Cite
@article{arxiv.1812.08031,
title = {Neural correlates of episodic memory in the Memento cohort},
author = {Stéphane Epelbaum and Vincent Bouteloup and Jean Mangin and Valentina La Corte and Raffaela Migliaccio and Hugo Bertin and Marie O. Habert and Clara Fischer and Chabha Azouani and Ludovic Fillon and Marie Chupin and Bruno Vellas and Florence Pasquier and Jean Dartigues and Frédéric Blanc and Audrey Gabelle and Mathieu Ceccaldi and Pierre Krolak-Salmon and Jacques Hugon and Olivier Hanon and Olivier Rouaud and Renaud David and Geneviève Chêne and Bruno Dubois and Carole Dufouil},
journal= {arXiv preprint arXiv:1812.08031},
year = {2018}
}