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Cutting edge techniques developed in the general NLP domain are often subsequently applied to the high-value, data-rich biomedical domain. The past few years have seen generative language models (LMs), instruction finetuning, and few-shot…

Computation and Language · Computer Science 2025-07-28 Aviv Brokman , Ramakanth Kavuluru

As large language models (LLMs) continue to advance, instruction tuning has become critical for improving their ability to generate accurate and contextually appropriate responses. Although numerous instruction-tuning datasets have been…

Computation and Language · Computer Science 2024-10-18 Jielin Song , Siyu Liu , Bin Zhu , Yanghui Rao

Instruction tuning of open-source large language models (LLMs) like LLaMA, using direct outputs from more powerful LLMs such as Instruct-GPT and GPT-4, has proven to be a cost-effective way to align model behaviors with human preferences.…

Computation and Language · Computer Science 2023-10-23 Haoran Li , Yiran Liu , Xingxing Zhang , Wei Lu , Furu Wei

Instruction tuning enhances large language models (LLMs) to follow human instructions across diverse tasks, relying on high-quality datasets to guide behavior. However, these datasets, whether manually curated or synthetically generated,…

Open-source, multilingual medical large language models (LLMs) have the potential to serve linguistically diverse populations across different regions. Adapting generic LLMs for healthcare often requires continual pretraining, but this…

Computation and Language · Computer Science 2024-09-10 Meng Zhou , Surajsinh Parmar , Anubhav Bhatti

In this work, we evaluate 10 open-source instructed LLMs on four representative code comprehension and generation tasks. We have the following main findings. First, for the zero-shot setting, instructed LLMs are very competitive on code…

Computation and Language · Computer Science 2023-08-03 Zhiqiang Yuan , Junwei Liu , Qiancheng Zi , Mingwei Liu , Xin Peng , Yiling Lou

Recent work has shown that fine-tuning large pre-trained language models on a collection of tasks described via instructions, a.k.a. instruction-tuning, improves their zero and few-shot generalization to unseen tasks. However, there is a…

Large language models (LLMs) have demonstrated remarkable prowess in language understanding and generation. Advancing from foundation LLMs to instructionfollowing LLMs, instruction tuning plays a vital role in aligning LLMs to human…

Computation and Language · Computer Science 2023-06-22 Shaolei Zhang , Qingkai Fang , Zhuocheng Zhang , Zhengrui Ma , Yan Zhou , Langlin Huang , Mengyu Bu , Shangtong Gui , Yunji Chen , Xilin Chen , Yang Feng

Advancements in Large Language Models (LLMs) have significantly enhanced instruction-following capabilities. However, most Instruction Fine-Tuning (IFT) datasets are predominantly in English, limiting model performance in other languages.…

Computation and Language · Computer Science 2024-07-03 Sathish Reddy Indurthi , Wenxuan Zhou , Shamil Chollampatt , Ravi Agrawal , Kaiqiang Song , Lingxiao Zhao , Chenguang Zhu

Objective: Most existing fine-tuned biomedical large language models (LLMs) focus on enhancing performance in monolingual biomedical question answering and conversation tasks. To investigate the effectiveness of the fine-tuned LLMs on…

Instruction tuning improves the reasoning abilities of large language models (LLMs), with data quality and scalability being the crucial factors. Most instruction tuning data come from human crowd-sourcing or GPT-4 distillation. We propose…

Computation and Language · Computer Science 2024-05-24 Xiang Yue , Tuney Zheng , Ge Zhang , Wenhu Chen

Large Language Models are traditionally finetuned on large instruction datasets. However recent studies suggest that small, high-quality datasets can suffice for general purpose instruction following. This lack of consensus surrounding…

Machine Learning · Computer Science 2023-12-29 Aditi Jha , Sam Havens , Jeremy Dohmann , Alex Trott , Jacob Portes

Large Language Models (LLMs) have achieved remarkable success, where instruction tuning is the critical step in aligning LLMs with user intentions. In this work, we investigate how the instruction tuning adjusts pre-trained models with a…

Computation and Language · Computer Science 2024-04-05 Xuansheng Wu , Wenlin Yao , Jianshu Chen , Xiaoman Pan , Xiaoyang Wang , Ninghao Liu , Dong Yu

Large Language Models (LLMs) for public use require continuous pre-training to remain up-to-date with the latest data. The models also need to be fine-tuned with specific instructions to maintain their ability to follow instructions…

Computation and Language · Computer Science 2024-10-15 Ishan Jindal , Chandana Badrinath , Pranjal Bharti , Lakkidi Vinay , Sachin Dev Sharma

Visual instruction tuning has recently shown encouraging progress with open-source large multimodal models (LMM) such as LLaVA and MiniGPT-4. However, most existing studies of open-source LMM are performed using models with 13B parameters…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Yadong Lu , Chunyuan Li , Haotian Liu , Jianwei Yang , Jianfeng Gao , Yelong Shen

Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

Computation and Language · Computer Science 2026-01-21 Muhammad Muneeb , David B. Ascher

Tabular instruction tuning has emerged as a promising research direction for improving LLMs understanding of tabular data. However, the majority of existing works only consider question-answering and reasoning tasks over tabular data,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Milad Abdollahzadeh , Abdul Raheem , Zilong Zhao , Uzair Javaid , Kevin Yee , Nalam Venkata Abhishek , Tram Truong-Huu , Biplab Sikdar

Large language models are trained in two stages: (1) unsupervised pretraining from raw text, to learn general-purpose representations, and (2) large scale instruction tuning and reinforcement learning, to better align to end tasks and user…

Computation and Language · Computer Science 2023-05-22 Chunting Zhou , Pengfei Liu , Puxin Xu , Srini Iyer , Jiao Sun , Yuning Mao , Xuezhe Ma , Avia Efrat , Ping Yu , Lili Yu , Susan Zhang , Gargi Ghosh , Mike Lewis , Luke Zettlemoyer , Omer Levy

With the capabilities of understanding and executing natural language instructions, Large language models (LLMs) can potentially act as a powerful tool for textual data augmentation. However, the quality of augmented data depends heavily on…

Computation and Language · Computer Science 2024-04-30 Yichuan Li , Kaize Ding , Jianling Wang , Kyumin Lee

Instruction-tuning language models has become a crucial step in aligning them for general use. Typically, this process involves extensive training on large datasets, incurring high training costs. In this paper, we introduce a novel…

Computation and Language · Computer Science 2024-02-19 Dheeraj Mekala , Alex Nguyen , Jingbo Shang