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Large language models (LLMs) trained on internet-scale corpora can exhibit systematic biases that increase the probability of unwanted behavior. In this study, we examined potential biases towards synthetic vs. biological technological…

Computation and Language · Computer Science 2026-03-11 Trent R Northen , Mingxun Wang

Instruction tuning is a pivotal technique for aligning large language models (LLMs) with human intentions, safety constraints, and domain-specific requirements. This survey provides a comprehensive overview of the full pipeline,…

Computation and Language · Computer Science 2025-11-20 Xudong Han , Junjie Yang , Tianyang Wang , Ziqian Bi , Xinyuan Song , Junfeng Hao , Junhao Song

Large Language Models (LLMs) have shown promising results on machine translation for high resource language pairs and domains. However, in specialised domains (e.g. medical) LLMs have shown lower performance compared to standard neural…

Computation and Language · Computer Science 2025-07-31 Miguel Rios

The integration of large language model (LLM) techniques in the field of medical analysis has brought about significant advancements, yet the scarcity of large, diverse, and well-annotated datasets remains a major challenge. Medical data…

Computation and Language · Computer Science 2024-10-18 Wenhan Han , Meng Fang , Zihan Zhang , Yu Yin , Zirui Song , Ling Chen , Mykola Pechenizkiy , Qingyu Chen

Large language models (LLMs) with instruction fine-tuning demonstrate superior generative capabilities. However, these models are resource-intensive. To alleviate this issue, we explore distilling knowledge from instruction-tuned LLMs into…

Computation and Language · Computer Science 2024-01-30 Minghao Wu , Abdul Waheed , Chiyu Zhang , Muhammad Abdul-Mageed , Alham Fikri Aji

Large language models (LLMs) hold the promise of solving diverse tasks when provided with appropriate natural language prompts. However, prompting often leads models to make predictions with lower accuracy compared to finetuning a model…

Computation and Language · Computer Science 2024-08-13 Chenyang Zhao , Xueying Jia , Vijay Viswanathan , Tongshuang Wu , Graham Neubig

Instruction fine-tuning is crucial for today's large language models (LLMs) to learn to follow instructions and align with human preferences. Conventionally, supervised data, including the instruction and the correct response, is required…

Computation and Language · Computer Science 2024-09-04 Juncheng Xie , Shensian Syu , Hung-yi Lee

Fine-tuning Large Language Models (LLMs) incurs considerable training costs, driving the need for data-efficient training with optimised data ordering. Human-inspired strategies offer a solution by organising data based on human learning…

Computation and Language · Computer Science 2024-11-06 Yushi Yang , Andrew M. Bean , Robert McCraith , Adam Mahdi

Despite the success of large language models (LLMs) on general-purpose tasks, their performance in highly specialized domains such as biomedicine remains unsatisfactory. A key limitation is the inability of LLMs to effectively leverage…

Computation and Language · Computer Science 2026-05-08 Xin Gao , Ruiyi Zhang , Meixi Du , Peijia Qin , Pengtao Xie

In recent years, instruction tuning has gained increasing attention and emerged as a crucial technique to enhance the capabilities of Large Language Models (LLMs). To construct high-quality instruction datasets, many instruction processing…

Computation and Language · Computer Science 2024-06-25 Yixin Ou , Ningyu Zhang , Honghao Gui , Ziwen Xu , Shuofei Qiao , Yida Xue , Runnan Fang , Kangwei Liu , Lei Li , Zhen Bi , Guozhou Zheng , Huajun Chen

Instruction tuning significantly enhances the performance of large language models (LLMs) across various tasks. However, the procedure to optimizing the mixing of instruction datasets for LLM fine-tuning is still poorly understood. This…

Computation and Language · Computer Science 2024-02-20 Renxi Wang , Haonan Li , Minghao Wu , Yuxia Wang , Xudong Han , Chiyu Zhang , Timothy Baldwin

Large vision language models (LVLMs) have demonstrated impressive performance across a wide range of tasks. These capabilities largely stem from visual instruction tuning, which fine-tunes models on datasets consisting of curated…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Myeongkyun Kang , Soopil Kim , Xiaoxiao Li , Sang Hyun Park

Instruction-tuning is a widely adopted finetuning method that enables large language models (LLMs) to generate output that more closely resembles human responses. However, no studies have shown that instruction-tuning actually teaches LLMs…

Computation and Language · Computer Science 2024-08-12 Khai Loong Aw , Syrielle Montariol , Badr AlKhamissi , Martin Schrimpf , Antoine Bosselut

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

We evaluate four state-of-the-art instruction-tuned large language models (LLMs) -- ChatGPT, Flan-T5 UL2, Tk-Instruct, and Alpaca -- on a set of 13 real-world clinical and biomedical natural language processing (NLP) tasks in English, such…

Computation and Language · Computer Science 2024-06-11 Yanis Labrak , Mickael Rouvier , Richard Dufour

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable capabilities in processing complex text information. But their…

Large language models (LLMs) have shown great potential in medical question answering (MedQA), yet adapting them to biomedical reasoning remains challenging due to domain-specific complexity and limited supervision. In this work, we study…

Computation and Language · Computer Science 2025-11-12 Chenqian Le , Ziheng Gong , Chihang Wang , Haowei Ni , Panfeng Li , Xupeng Chen

Large Language Models (LLMs) have demonstrated significant potential in transforming clinical applications. In this study, we investigate the efficacy of four techniques in adapting LLMs for clinical use-cases: continuous pretraining,…

Large Language Models (LLMs) have the unique capability to understand and generate human-like text from input queries. When fine-tuned, these models show enhanced performance on domain-specific queries. OpenAI highlights the process of…

Computation and Language · Computer Science 2024-07-02 Scott Barnett , Zac Brannelly , Stefanus Kurniawan , Sheng Wong

Pretrained large language models (LLMs) are currently state-of-the-art for solving the vast majority of natural language processing tasks. While many real-world applications still require fine-tuning to reach satisfactory levels of…