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Large Language Models (LLMs), particularly those similar to ChatGPT, have significantly influenced the field of Natural Language Processing (NLP). While these models excel in general language tasks, their performance in domain-specific…

Computation and Language · Computer Science 2024-01-02 Omid Rohanian , Mohammadmahdi Nouriborji , David A. Clifton

Large Language Models (LLMs) are expected to significantly contribute to patient care, diagnostics, and administrative processes. Emerging biomedical LLMs aim to address healthcare-specific challenges, including privacy demands and…

Computation and Language · Computer Science 2025-10-14 Amin Dada , Marie Bauer , Amanda Butler Contreras , Osman Alperen Koraş , Constantin Marc Seibold , Kaleb E Smith , Jens Kleesiek

Large Language Models (LLMs), with their remarkable task-handling capabilities and innovative outputs, have catalyzed significant advancements across a spectrum of fields. However, their proficiency within specialized domains such as…

Quantitative Methods · Quantitative Biology 2024-03-05 Yin Fang , Xiaozhuan Liang , Ningyu Zhang , Kangwei Liu , Rui Huang , Zhuo Chen , Xiaohui Fan , Huajun Chen

Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale…

Large language models (LLMs) such as ChatGPT are fine-tuned on large and diverse instruction-following corpora, and can generalize to new tasks. However, those instruction-tuned LLMs often perform poorly in specialized medical natural…

Computation and Language · Computer Science 2025-03-11 Yujuan Velvin Fu , Giridhar Kaushik Ramachandran , Namu Park , Kevin Lybarger , Fei Xia , Ozlem Uzuner , Meliha Yetisgen

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Large Language Models (LLMs) demonstrate strong performance in real-world applications, yet existing open-source instruction datasets often concentrate on narrow domains, such as mathematics or coding, limiting generalization and widening…

Computation and Language · Computer Science 2025-06-16 Jijie Li , Li Du , Hanyu Zhao , Bo-wen Zhang , Liangdong Wang , Boyan Gao , Guang Liu , Yonghua Lin

Despite the effectiveness of vision-language supervised fine-tuning in enhancing the performance of Vision Large Language Models (VLLMs). However, existing visual instruction tuning datasets include the following limitations: (1)…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Yangzhou Liu , Yue Cao , Zhangwei Gao , Weiyun Wang , Zhe Chen , Wenhai Wang , Hao Tian , Lewei Lu , Xizhou Zhu , Tong Lu , Yu Qiao , Jifeng Dai

Large language models (LLMs) have demonstrated outstanding performance in natural language processing tasks. However, in the field of recommender systems, due to the inherent structural discrepancy between user behavior data and natural…

Information Retrieval · Computer Science 2026-01-01 Zekun Liu , Xiaowen Huang , Jitao Sang

Due to limited supervised training data, large language models (LLMs) are typically pre-trained via a self-supervised "predict the next word" objective on a vast amount of unstructured text data. To make the resulting model useful to users,…

Computation and Language · Computer Science 2026-01-30 Ajay Patel , Colin Raffel , Chris Callison-Burch

Large Language Models (LLMs) have transformed software development by enabling code generation, automated debugging, and complex reasoning. However, their continued advancement is constrained by the scarcity of high-quality, publicly…

Software Engineering · Computer Science 2025-08-11 Wasi Uddin Ahmad , Aleksander Ficek , Mehrzad Samadi , Jocelyn Huang , Vahid Noroozi , Somshubra Majumdar , Boris Ginsburg

Large language models (LLMs) can perform a wide range of tasks by following natural language instructions, without the necessity of task-specific fine-tuning. Unfortunately, the performance of LLMs is greatly influenced by the quality of…

Computation and Language · Computer Science 2023-10-23 Zhihan Zhang , Shuohang Wang , Wenhao Yu , Yichong Xu , Dan Iter , Qingkai Zeng , Yang Liu , Chenguang Zhu , Meng Jiang

Proprietary Large Language Models (LLMs), such as ChatGPT, have garnered significant attention due to their exceptional capabilities in handling a diverse range of tasks. Recent studies demonstrate that open-sourced smaller foundational…

Computation and Language · Computer Science 2023-10-10 Yue Zhang , Leyang Cui , Deng Cai , Xinting Huang , Tao Fang , Wei Bi

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

Large language models (LLMs) are initially pretrained for broad capabilities and then finetuned with instruction-following datasets to improve their performance in interacting with humans. Despite advances in finetuning, a standardized…

Computation and Language · Computer Science 2024-07-30 Yihan Cao , Yanbin Kang , Chi Wang , Lichao Sun

Training large language models (LLMs) to follow instructions has significantly enhanced their ability to tackle unseen tasks. However, despite their strong generalization capabilities, instruction-following LLMs encounter difficulties when…

Computation and Language · Computer Science 2025-05-29 Maja Stahl , Timon Ziegenbein , Joonsuk Park , Henning Wachsmuth

Large language models (LLMs) have demonstrated impressive capabilities in various natural language processing tasks. Despite this, their application to information retrieval (IR) tasks is still challenging due to the infrequent occurrence…

Computation and Language · Computer Science 2024-05-29 Yutao Zhu , Peitian Zhang , Chenghao Zhang , Yifei Chen , Binyu Xie , Zheng Liu , Ji-Rong Wen , Zhicheng Dou

Instruction tuning is crucial for enabling Large Language Models (LLMs) to solve real-world tasks. Prior work has shown the effectiveness of instruction-tuning data synthesized solely from LLMs, raising a fundamental question: Do we still…

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of…

Fine-tuning large language models (LLMs) on multi-task instruction-following data has been proven to be a powerful learning paradigm for improving their zero-shot capabilities on new tasks. Recent works about high-quality…

Computation and Language · Computer Science 2024-06-17 Wei Han , Hui Chen , Soujanya Poria
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