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Type 1 diabetes (T1D) management can be significantly enhanced through the use of predictive machine learning (ML) algorithms, which can mitigate the risk of adverse events like hypoglycemia. Hypoglycemia, characterized by blood glucose…

Quantitative Methods · Quantitative Biology 2025-04-02 Beyza Cinar , Jennifer Daniel Onwuchekwa , Maria Maleshkova

\begin{abstract} We model individual T2DM patient blood glucose level (BGL) by stochastic process with discrete number of states mainly but not solely governed by medication regimen (e.g. insulin injections). BGL states change otherwise…

Quantitative Methods · Quantitative Biology 2017-10-24 Mark Shifrin , Hava Siegelmann

Modern treatments for Type 1 diabetes (T1D) use devices known as artificial pancreata (APs), which combine an insulin pump with a continuous glucose monitor (CGM) operating in a closed-loop manner to control blood glucose levels. In…

Machine Learning · Computer Science 2018-12-04 Matthew O'Kelly , Aman Sinha , Justin Norden , Hongseok Namkoong

High quality real world datasets are essential for advancing data driven approaches in type 1 diabetes (T1D) management, including personalized therapy design, digital twin systems, and glucose prediction models. However, progress in this…

Machine Learning · Computer Science 2025-06-19 Saman Khamesian , Asiful Arefeen , Bithika M. Thompson , Maria Adela Grando , Hassan Ghasemzadeh

We propose and create an incentive based recommendation algorithm aimed at improving the lifestyle of diabetic patients. This algorithm is integrated into a real world mobile application to provide personalized health recommendations.…

Human-Computer Interaction · Computer Science 2025-04-22 Wasim Abbas , Hafiz Syed Muhammad Bilal , Asim Abbas , Muhammad Afzal , Je-Hoon Lee

Diabetes mellitus is a global health crisis characterized by poor blood sugar regulation, impacting millions of people worldwide and leading to severe complications and mortality. Although Type 1 Diabetes Mellitus (T1DM) has a lower number…

Other Quantitative Biology · Quantitative Biology 2025-04-14 Rinrada Jadsadaphongphaibool , Dadi Bi , Christian D. Lorenz , Yansha Deng , Robert Schober

Fluid administration, also called fluid resuscitation, is a medical treatment to restore the lost blood volume and optimize cardiac functions in critical care scenarios such as burn, hemorrhage, and septic shock. Automated fluid…

Systems and Control · Electrical Eng. & Systems 2024-01-15 Elham Estiri , Hossein Mirinejad

In this paper, we study the problem of blood glucose forecasting and provide a deep personalized solution. Predicting blood glucose level in people with diabetes has significant value because health complications of abnormal glucose level…

Machine Learning · Computer Science 2021-09-08 Mohammadreza Armandpour , Brian Kidd , Yu Du , Jianhua Z. Huang

Effective traffic control is essential for mitigating congestion in transportation networks. Conventional traffic management strategies, including route guidance and ramp metering, often rely on state feedback controllers, which are used…

Machine Learning · Computer Science 2026-04-13 Giray Önür , Azita Dabiri , Bart De Schutter

Medical Large Vision-Language Models (Med-LVLMs) have shown strong potential in multimodal diagnostic tasks. However, existing single-agent models struggle to generalize across diverse medical specialties, limiting their performance. Recent…

Machine Learning · Computer Science 2026-01-27 Peng Xia , Jinglu Wang , Yibo Peng , Kaide Zeng , Zihan Dong , Xian Wu , Xiangru Tang , Hongtu Zhu , Yun Li , Linjun Zhang , Shujie Liu , Yan Lu , Huaxiu Yao

Objective: The design of an Artificial Pancreas (AP) to regulate blood glucose levels requires reliable control methods. Model Predictive Control has emerged as a promising approach for glycemia control. However, model--based control…

Optimization and Control · Mathematics 2022-02-02 Claudia Lopez-Zazueta , Øyvind Stavdahl , Anders Lyngvi Fougner

The dead-in-bed syndrome describes the sudden and unexplained death of young individuals with Type 1 Diabetes (T1D) without prior long-term complications. One leading hypothesis attributes this phenomenon to nocturnal hypoglycemia (NH), a…

Machine Learning · Computer Science 2025-04-15 Marco Voegeli , Sonia Laguna , Heike Leutheuser , Marc Pfister , Marie-Anne Burckhardt , Julia E Vogt

In the UK, approximately 400,000 people with type 1 diabetes (T1D) rely on insulin delivery due to insufficient pancreatic insulin production. Managing blood glucose (BG) levels is crucial, with continuous glucose monitoring (CGM) playing a…

Machine Learning · Computer Science 2023-12-21 Chengzhe Piao , Ken Li

We propose a reinforcement learning (RL)-based system that would automatically prescribe a hypothetical patient medication that may help the patient with their mental health-related speech disfluency, and adjust the medication and the…

Around a third of type 2 diabetes patients (T2D) are escalated to basal insulin injections. Basal insulin dose is titrated to achieve a tight glycemic target without undue hypoglycemic risk. In the standard of care (SoC), titration is based…

Systems and Control · Electrical Eng. & Systems 2023-09-19 Anas El Fathi , Mohammadreza Ganji , Dimitri Boiroux , Henrik Bengtsson , Marc D. Breton

Effective patient monitoring is vital for timely interventions and improved healthcare outcomes. Traditional monitoring systems often struggle to handle complex, dynamic environments with fluctuating vital signs, leading to delays in…

Machine Learning · Computer Science 2024-10-30 Thanveer Shaik , Xiaohui Tao , Lin Li , Haoran Xie , Hong-Ning Dai , Feng Zhao , Jianming Yong

The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either…

Tissues and Organs · Quantitative Biology 2019-06-19 Afroza Shirin , Fabio Della Rossa , Isaac Klickstein , John Russell , Francesco Sorrentino

The recent DeepSeek-R1 has showcased the emergence of reasoning capabilities in LLMs through reinforcement learning (RL) with rule-based rewards. Despite its success in language models, its application in multi-modal domains, particularly…

Artificial Intelligence · Computer Science 2025-05-27 Zhengxi Lu , Yuxiang Chai , Yaxuan Guo , Xi Yin , Liang Liu , Hao Wang , Han Xiao , Shuai Ren , Guanjing Xiong , Hongsheng Li

We present the design and \textit{in-silico} evaluation of a closed-loop insulin delivery algorithm to treat type 1 diabetes (T1D) consisting in a data-driven multi-step-ahead blood glucose (BG) predictor integrated into a Linear…

Systems and Control · Electrical Eng. & Systems 2023-07-25 Eleonora Maria Aiello , Mehrad Jaloli , Marzia Cescon

Reinforcement learning (RL) agents with pre-specified reward functions cannot provide guaranteed safety across variety of circumstances that an uncertain system might encounter. To guarantee performance while assuring satisfaction of safety…

Artificial Intelligence · Computer Science 2021-04-20 Aquib Mustafa , Majid Mazouchi , Subramanya Nageshrao , Hamidreza Modares