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Fluorescence imaging is indispensable to biology and neuroscience. The need for large-scale imaging in freely behaving animals has further driven the development in miniaturized microscopes (miniscopes). However, conventional microscopes /…
Interferometric imaging is a well established method to image phase objects by mixing the image wavefront with a reference one on a CCD camera. It has also been applied to fast transient phenomena, mostly through the analysis of single…
We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…
A recently introduced two-channel confocal microscope with correlated detection promises up to 50% improvement in transverse spatial resolution [Simon, Sergienko, Optics Express {\bf 18}, 9765 (2010)] via the use of photon correlations.…
We present a scalable scheme to achieve photon distillation, i.e. the preparation of a single photon with reduced indistinguishability error out of multiple imperfect photons, based on multiphoton interference in Fourier matrices. Our…
Colocalization is a powerful tool to study the interactions between fluorescently labeled molecules in biological fluorescence microscopy. However, existing techniques for colocalization analysis have not undergone continued development…
Fundamental properties of light unavoidably impose features on images collected using fluorescence microscopes. Modeling these features is ever more important in quantitatively interpreting microscopy images collected at scales on par or…
There is currently no widely adopted standard for the optical characterisation of fluorescence microscopes. We used laser written fluorescence to generate two- and three-dimensional patterns to deliver a quick and quantitative measure of…
Determining the number of fluorescent entities that are coupled to a given molecule (DNA, protein, etc.) is a key point of numerous biological studies, especially those based on a single molecule approach. Reliable methods are important, in…
Fundamental understanding of biological pathways requires minimally invasive nanoscopic optical resolution imaging. Many approaches to high-resolution imaging rely on localization of single emitters, such as fluorescent molecule or quantum…
The measurement problem is approached from a mechanical aspect, utilizing schematics to better assist in visualizing the boundary and the interplay between the quantum and classical worlds. This approach graphically illustrates what happens…
One of the main limitations for the resolution of optical instruments is the size of the sensor's pixels. In this paper we introduce a new sub pixel resolution algorithm to enhance the resolution of images. This method is based on the…
A novel method to estimate the pixels simultaneous detection probability and the spatial resolution of pixelized detectors is proposed, which is based on the determination of the statistical correlations between detector neighbor pixels.…
Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but lacks chemical sensitivity limiting its application to…
This work studies the problem of few-shot object counting, which counts the number of exemplar objects (i.e., described by one or several support images) occurring in the query image. The major challenge lies in that the target objects can…
This paper presents a renewed overview of photosensor oculography (PSOG), an eye-tracking technique based on the principle of using simple photosensors to measure the amount of reflected (usually infrared) light when the eye rotates.…
Polarization is a fundamental property of light that carries distinct and valuable information. Consequently, its precise measurement is crucial for numerous applications, including biomedical imaging, remote sensing, and optical…
We experimentally demonstrate a testing strategy for boson samplers that is based on efficiently computable expressions for the output photon counting distributions binned over multiple optical modes. We apply this method to validate boson…
Microscopy is the workhorse of the physical and life sciences, producing crisp images of everything from atoms to cells well beyond the capabilities of the human eye. However, the analysis of these images is frequently little better than…
The learning of the physical world relies on sensing and data post-processing. When the signals are weak, multidimensional and correlated, the performance of learning is often bottlenecked by the quality of sensors, calling for integrating…