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Optimal control of interdependent epidemics spreading over complex networks is a critical issue. We first establish a framework to capture the coupling between two epidemics, and then analyze the system's equilibrium states by categorizing…

Systems and Control · Computer Science 2017-10-19 Juntao Chen , Rui Zhang , Quanyan Zhu

In this paper we study a diffusive age structured epidemic model with disease transmission between vector and host populations. The dynamics of the populations are described by reaction-diffusion equations, with infection age structure of…

Analysis of PDEs · Mathematics 2017-06-15 William E. Fitzgibbon , Jeffrey J. Morgan , Glenn F. Webb , Yixiang Wu

During the last decades, the global prevalence of dengue progressed dramatically. It is a disease that is now endemic in more than one hundred countries of Africa, America, Asia, and the Western Pacific. In this paper, we present a…

Major advances in public health have resulted from disease prevention. However, prevention of a new infectious disease by vaccination or pharmaceuticals is made difficult by the slow process of vaccine and drug development. We propose an…

Populations and Evolution · Quantitative Biology 2021-04-15 Jussi Taipale , Ioannis Kontoyiannis , Sten Linnarsson

We approach the development of models and control strategies of susceptible-infected-susceptible (SIS) epidemic processes from the perspective of marked temporal point processes and stochastic optimal control of stochastic differential…

Optimization and Control · Mathematics 2018-12-04 Lars Lorch , Abir De , Samir Bhatt , William Trouleau , Utkarsh Upadhyay , Manuel Gomez-Rodriguez

In the present paper, we are concerned with an SIS epidemic reaction-diffusion model governed by mass action infection mechanism and linear birth-death growth with no flux boundary condition. By performing qualitative analysis, we study the…

Analysis of PDEs · Mathematics 2018-07-11 Huicong Li , Rui Peng , Zhi-An Wang

In this article, we construct a numerical method for a stochastic version of the Susceptible Infected Susceptible (SIS) epidemic model, expressed by a suitable stochastic differential equation (SDE), by using the semi-discrete method to a…

Numerical Analysis · Mathematics 2023-07-28 Yiannis Kiouvrekis , Ioannis S. Stamatiou

The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary case…

Quantitative Methods · Quantitative Biology 2025-01-23 Hannah Craddock , Simon EF Spencer , Xavier Didelot

A class of stochastic vector-borne infectious disease models is derived and studied. The class type is determined by a general nonlinear incidence rate of the disease. The disease spreads in a highly random environment with variability from…

Populations and Evolution · Quantitative Biology 2020-05-05 Divine Wanduku

During the last decades, the global prevalence of dengue progressed dramatically. It is a disease which is now endemic in more than one hundred countries of Africa, America, Asia and the Western Pacific. This study addresses a mathematical…

Efficient testing and vaccination protocols are critical aspects of epidemic management. To study the optimal allocation of limited testing and vaccination resources in a heterogeneous contact network of interacting susceptible, recovered,…

Populations and Evolution · Quantitative Biology 2026-05-12 Mingtao Xia , Lucas Böttcher , Tom Chou

We introduce a methodology to guarantee safety against the spread of infectious diseases by viewing epidemiological models as control systems and by considering human interventions (such as quarantining or social distancing) as control…

Systems and Control · Electrical Eng. & Systems 2022-11-21 Tamas G. Molnar , Andrew W. Singletary , Gabor Orosz , Aaron D. Ames

In this paper, we study a novel control method for a generalized SIS epidemic process. In particular, we use predictive control to design optimal protective resource distribution strategies which balance the need to eliminate the epidemic…

Optimization and Control · Mathematics 2018-08-17 Nicholas J. Watkins , George J. Pappas

We study a diffusive SIS epidemic model with the mass-action transmission mechanism and show, under appropriate assumptions on the parameters, the existence of multiple endemic equilibria (EE). Our results answer some open questions on…

Analysis of PDEs · Mathematics 2023-11-07 Keoni Castellano , Rachidi B. Salako

Is it possible to break the host-vector chain of transmission when there is an influx of infectious hosts into a na\"{i}ve population and competent vector? To address this question, a class of vector-borne disease models with an arbitrary…

Populations and Evolution · Quantitative Biology 2018-10-17 Derdei Bichara

An SIRS epidemiological model for a vertically transmitted disease is discussed. We give a complete global analysis in terms of three explicit threshold parameters which respectively govern the existence and stability of an endemic…

Classical Analysis and ODEs · Mathematics 2007-05-23 M. R. Razvan

Human to human transmissible infectious diseases spread in a population using human interactions as its transmission vector. The early stages of such an outbreak can be modeled by a graph whose edges encode these interactions between…

Populations and Evolution · Quantitative Biology 2020-06-11 Goncalo Oliveira

Research in epidemiology often focusses on designing interventions that result in the number of infected individuals asymptotically approaching zero, without considering that this number may peak at high values during transients. Recent…

Optimization and Control · Mathematics 2020-03-24 Willem Esterhuizen , Tim Aschenbruck , Jean Lévine , Stefan Streif

Ordinary differential equation (ODE) models used in mathematical epidemiology assume explicitly or implicitly large populations. For the study of infections in a hospital this is an extremely restrictive assumption as typically a hospital…

Populations and Evolution · Quantitative Biology 2023-08-21 Fabio A. C. C. Chalub , Antonio Gómez-Corral , Martín López-García , Fátima Palacios-Rodríguez

Traditional studies about disease dynamics have focused on global stability issues, due to their epidemiological importance. We study a classical SIR-SI model for arboviruses in two different directions: we begin by describing an…

Populations and Evolution · Quantitative Biology 2014-08-28 Max O. Souza
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