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A common problem in numerous research areas, particularly in clinical trials, is to test whether the effect of an explanatory variable on an outcome variable is equivalent across different groups. In practice, these tests are frequently…

Methodology · Statistics 2024-05-03 Niklas Hagemann , Kathrin Möllenhoff

The design of experiments in psychology can often be summarized to participants reacting to stimuli. For such an experiment, the mixed effects model with crossed random effects is usually the appropriate tool to analyse the data because it…

Methodology · Statistics 2020-10-19 Jaromil Frossard , Olivier Renaud

Small study effects occur when smaller studies show different, often larger, treatment effects than large ones, which may threaten the validity of systematic reviews and meta-analyses. The most well-known reasons for small study effects…

Assessment of multimedia quality relies heavily on subjective assessment, and is typically done by human subjects in the form of preferences or continuous ratings. Such data is crucial for analysis of different multimedia processing…

Multimedia · Computer Science 2018-01-26 Manish Narwaria , Lukas Krasula , Patrick Le Callet

ANOVA Simultaneous Component Analysis (ASCA) is the current state-of-theart chemometric tool for analyzing and interpreting high-dimensional experimental data from a Design of Experiment (DoE). Being a multivariate extension of the ANOVA,…

Methodology · Statistics 2026-05-20 José Camacho , Jokin Ezenarro , Daniel Schorn-García , Johan A. Westerhuis

We propose a powerful adaptive contrast test with ordinal constraint contrast coefficients determined by observed responses. The adaptive contrast test can perform using easily calculated contrast coefficients and existing statistical…

Methodology · Statistics 2021-09-23 Masahiro Kojima

While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only account for a small proportion of heritability. Challenges remain…

Applications · Statistics 2025-08-18 Olga A. Vsevolozhskaya , Dmitri V. Zaykin , Mark C. Greenwood , Changshuai Wei , Qing Lu

Studies to compare the survival of two or more groups using time-to-event data are of high importance in medical research. The gold standard is the log-rank test, which is optimal under proportional hazards. As the latter is no simple…

Methodology · Statistics 2022-10-25 Ina Dormuth , Tiantian Liu , Jin Xu , Markus Pauly , Marc Ditzhaus

Network meta-analysis (NMA) is widely used to compare multiple interventions simultaneously by synthesizing direct and indirect evidence. The general fixed or random effects contrast-based NMA model can be applied to different outcomes and…

Methodology · Statistics 2026-03-03 Harlan Campbell , Jeroen P. Jansen

Standard (network) meta-analysis methods for medical test accuracy evaluation analyse the data separately for each test threshold - wasting data - unless every study reports all thresholds. Previously proposed "multiple threshold" models…

The paper introduces a novel approach to global sensitivity analysis, grounded in the variance-covariance structure of random variables derived from random measures. The proposed methodology facilitates the application of…

Methodology · Statistics 2025-10-20 Caleb Deen Bastian , Herschel Rabitz , Grzegorz A Rempala

A new method based on the rejection sampling for finding statistical tests is proposed. This method is conceptually intuitive, easy to implement, and applicable for arbitrary dimension. To illustrate its potential applicability, three…

Methodology · Statistics 2026-03-11 Markku Kuismin

It is largely taken for granted that differential abundance analysis is, by default, the best first step when analyzing genomic data. We argue that this is not necessarily the case. In this article, we identify key limitations that are…

Methodology · Statistics 2021-06-09 Thomas P Quinn , Elliott Gordon-Rodriguez , Ionas Erb

Classical analysis of variance requires that model terms be labeled as fixed or random and typically culminate by comparing variability from each batch (factor) to variability from errors; without a standard methodology to assess the…

Methodology · Statistics 2012-07-17 Steven Geinitz , Reinhard Furrer , Stephan R. Sain

Loss of power and clear description of treatment differences are key issues in designing and analyzing a clinical trial where non-proportional hazard is a possibility. A log-rank test may be very inefficient and interpretation of the hazard…

Applications · Statistics 2021-01-13 Satrajit Roychoudhury , Keaven M Anderson , Jiabu Ye , Pralay Mukhopadhyay

This paper considers the problem of estimating the variance of a sum of a triangular array of random vectors with heterogeneous means. When random vectors exhibit two-way cluster dependence or weak dependence, standard variance estimators…

Econometrics · Economics 2026-03-13 Luther Yap

We test against two different sets of data an apparently new approach to the analysis of the variance of a numerical variable which depends on qualitative characters. We suggest that this approach be used to complement other existing…

Temporal dependence and the resulting autocovariances in time series data can introduce bias into ANOVA test statistics, thereby affecting their size and power. This manuscript accounts for temporal dependence in ANOVA and develops a test…

Statistics Theory · Mathematics 2025-09-12 Yunyi Zhang

Positive and negative likelihood ratios are parameters which are used to assess and compare the effectiveness of binary diagnostic tests. Both parameters only depend on the sensitivity and specificity of the diagnostic test and are…

Other Statistics · Statistics 2024-09-02 Jose Antonio Roldan-Nofuentes , Saad Bouh Sidaty-Regad

The comparison of proportions is considered in the asymptotic generalized linear model with the odds ratio as effect size. When several doses are compared with a control assuming an order restriction, a Williams-type trend test can be used.…

Applications · Statistics 2020-11-30 Ludwig A. Hothorn