Comparisons of proportions in k dose groups against a negative control assuming order restriction: Williams-type test vs. closed test procedures
Applications
2020-11-30 v1 Other Statistics
Abstract
The comparison of proportions is considered in the asymptotic generalized linear model with the odds ratio as effect size. When several doses are compared with a control assuming an order restriction, a Williams-type trend test can be used. As an alternative, two variants of the closed testing approach are considered, one using global Williams-tests in the partition hypotheses, one with pairwise contrasts. Their advantages in terms of power and simplicity are demonstrated. Related R-code is provided.
Keywords
Cite
@article{arxiv.2011.13758,
title = {Comparisons of proportions in k dose groups against a negative control assuming order restriction: Williams-type test vs. closed test procedures},
author = {Ludwig A. Hothorn},
journal= {arXiv preprint arXiv:2011.13758},
year = {2020}
}
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