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Standard ANOVA is among the most widely used tests in the life sciences and beyond. Several alternatives are proposed to provide simultaneous confidence intervals, ensure tight control of FWER, be robust to variance heterogeneity, avoid…

Methodology · Statistics 2022-06-01 Ludwig A. Hothorn

Traditional analysis of variance (ANOVA) software allows researchers to test for the significance of main effects in the presence of interactions without exposure to the details of how the software encodes main effects and interactions to…

Methodology · Statistics 2018-01-16 Roger Levy

Popular software packages report four generalizations of the ANOVA F test when conducting a multivariate analysis of variance (MANOVA). The reported operating characteristics of these fours tests vary widely depending on which research…

Computation · Statistics 2026-04-22 Joseph D Consiglio

Many psychologists do not realize that exploratory use of the popular multiway analysis of variance (ANOVA) harbors a multiple comparison problem. In the case of two factors, three separate null hypotheses are subject to test (i.e., two…

Testing for the significance of a subset of regression coefficients in a linear model, a staple of statistical analysis, goes back at least to the work of Fisher who introduced the analysis of variance (ANOVA). We study this problem under…

Statistics Theory · Mathematics 2012-02-24 Ery Arias-Castro , Emmanuel J. Candès , Yaniv Plan

Analysis of variance (ANOVA) is an extremely important method in exploratory and confirmatory data analysis. Unfortunately, in complex problems (e.g., split-plot designs), it is not always easy to set up an appropriate ANOVA. We propose a…

Statistics Theory · Mathematics 2007-06-13 Andrew Gelman

The present study defines a new statistic for detecting laboratory effects in the analysis of ordinal variation (ORDANOVA). The ORDANOVA is an analysis method similar to one-way analysis of variance for analysing ordinal data obtained from…

Applications · Statistics 2022-02-10 Jun-ichi Takeshita , Yuto Arai , Mayu Ogawa , Xiao-Nan Lu , Tomomichi Suzuki

Assessing variability according to distinct factors in data is a fundamental technique of statistics. The method commonly regarded to as analysis of variance (ANOVA) is, however, typically confined to the case where all levels of a factor…

Methodology · Statistics 2013-03-15 Steven Geinitz , Reinhard Furrer

Factorial experiments in research on memory, language, and in other areas are often analyzed using analysis of variance (ANOVA). However, for effects with more than one numerator degrees of freedom, e.g., for experimental factors with more…

Methodology · Statistics 2019-07-19 Daniel J. Schad , Shravan Vasishth , Sven Hohenstein , Reinhold Kliegl

When comparing multiple groups in clinical trials, we are not only interested in whether there is a difference between any groups but rather the location. Such research questions lead to testing multiple individual hypotheses. To control…

Most comparisons of treatments or doses against a control are performed by the original Dunnett single step procedure \cite{Dunnett1955} providing both adjusted p-values and simultaneous confidence intervals for differences to the control.…

Methodology · Statistics 2023-03-17 Ludwig A. Hothorn , Mario Hasler

Meta-analysis aims to combine effect measures from several studies. For continuous outcomes, the most popular effect measures use simple or standardized differences in sample means. However, a number of applications focus on the absolute…

Methodology · Statistics 2023-10-03 Elena Kulinskaya , David C. Hoaglin

The likelihood ratio test against a tree ordered alternative in one-way heteroscedastic ANOVA is considered for the first time. Bootstrap is used to implement this and two multiple comparisons based tests and shown to have very good size…

Methodology · Statistics 2025-07-24 Subha Halder , Anjana Mondal , Somesh Kumar

Sample size calculation is crucial in biomedical in vivo research investigations mainly for two reasons: to design the most resource-efficient studies and to safeguard ethical issues when alive animals are subjects of testing. In this…

Applications · Statistics 2025-05-27 Hasan Al-Nashash , Jiajin Wei , Ke Yang , Ayman Alzaatreh , Mohsen Adeli , Tiejun Tong , Angelo All

New tests are developed for two-way ANOVA models with heterogeneous error variances. The testing problems are considered for testing the significant interaction effects, simple effects, and treatment effects. The likelihood ratio tests…

Methodology · Statistics 2026-03-02 Anjana Mondal , Somesh Kumar

Stratifying factors, like age and gender, can modify the effect of treatments and exposures on risk of a studied outcome. Several effect measures, including the relative risk, hazard ratio, odds ratio, and risk difference, can be used to…

Methodology · Statistics 2021-11-05 Jake Shannin , Babette A. Brumback

Comparing the mean vectors across different groups is a cornerstone in the realm of multivariate statistics, with quadratic forms commonly serving as test statistics. However, when the overall hypothesis is rejected, identifying specific…

Methodology · Statistics 2025-06-04 Paavo Sattler , Markus Pauly , Merle Munko

When evaluating the clinical performance of a medical imaging device, a multi-reader multi-case (MRMC) analysis is usually applied to account for both case and reader variability. For a clinical task that equates to a quantitative…

Quantitative Methods · Quantitative Biology 2021-07-20 Si Wen , Brandon D. Gallas

Factorial designs are frequently used in different fields of science, e.g. psychological, medical or biometric studies. Standard approaches, as the ANOVA $F$-test, make different assumptions on the distribution of the error terms, the…

Methodology · Statistics 2018-02-21 Maria Umlauft

One limitation on the performance of optical traps is the noise inherently present in every setup. Therefore, it is the desire of most experimentalists to minimize and possibly eliminate noise from their optical trapping experiments. A step…

Data Analysis, Statistics and Probability · Physics 2009-09-01 Fabian Czerwinski , Andrew C. Richardson , Christine Selhuber-Unkel , Lene B. Oddershede
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