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Poor access to eye care is a major global challenge that could be ameliorated by low-cost, portable, and easy-to-use diagnostic technologies. Diffuser-based imaging has the potential to enable inexpensive, compact optical systems that can…

Medical Physics · Physics 2020-06-23 Yunzhe Li , Gregory N. McKay , Nicholas J. Durr , Lei Tian

We present a deep learning driven computational approach to overcome the limitations of self-interference digital holography that imposed by inferior axial imaging performances. We demonstrate a 3D deep neural network model can…

We present a tomographic imaging technique, termed Deep Prior Diffraction Tomography (DP-DT), to reconstruct the 3D refractive index (RI) of thick biological samples at high resolution from a sequence of low-resolution images collected…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Kevin C. Zhou , Roarke Horstmeyer

Holographic Tomography (HT) or Optical Diffraction Tomography (ODT) provides slice-by-slice information about the refractive index (RI) of three-dimensional (3D) samples and is emerging as an important label-free imaging modality for Life…

Image and Video Processing · Electrical Eng. & Systems 2025-04-22 N Goyal , K Khare

One-shot full-field surface profilometry using digital diffractive-confocal imaging correlation microscope based on digital micromirror device is developed for one-shot microscopic 3D surface measurement. Optical configuration applies…

Optics · Physics 2019-04-24 Duc Trung Nguyen , Liang-Chia Chen , Nguyen Dinh Nguyen

Recovering molecular information remains a grand challenge in the widely used holographic and computational imaging technologies. To address this challenge, we developed a computational mid-infrared photothermal microscope, termed…

The highest three-dimensional (3D) resolution possible in in-vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics (AO). However, this combination brings important limitations, such as small…

Medical Physics · Physics 2020-10-21 Jules Scholler , Kassandra Groux , Kate Grieve , Claude Boccara , Pedro Mecê

Infrared thermography (IRT) and photothermal coherence tomography (PCT) exhibit potential in non-destructive testing and biomedical fields. However, the inevitable heat diffusion significantly affects the sensitivity and resolution of IRT…

Reflectance Confocal Microscopy (RCM) is a non-invasive imaging technique used in biomedical research and clinical dermatology. It provides virtual high-resolution images of the skin and superficial tissues, reducing the need for physical…

Image and Video Processing · Electrical Eng. & Systems 2024-04-26 Hong-Jun Yoon , Chris Keum , Alexander Witkowski , Joanna Ludzik , Tracy Petrie , Heidi A. Hanson , Sancy A. Leachman

Optical diffraction tomography (ODT) enables non-invasive information-rich 3D refractive index (RI) reconstruction of unimpaired transparent biological and technical samples, crucial in biomedical research, optical metrology, materials…

Label-free metabolic dynamics contrast is highly appealing but difficult to achieve in biomedical imaging. Interference offers a highly sensitive mechanism for capturing the metabolic dynamics of the subcellular scatterers. However,…

We demonstrate a label-free, scan-free {\it intensity} diffraction tomography technique utilizing annular illumination (aIDT) to rapidly characterize large-volume 3D refractive index distributions in vitro. By optimally matching the…

Optics · Physics 2020-01-01 Jiaji Li , Alex Matlock , Yunzhe Li , Qian Chen , Chao Zuo , Lei Tian

We propose FlowReg, a deep learning-based framework for unsupervised image registration for neuroimaging applications. The system is composed of two architectures that are trained sequentially: FlowReg-A which affinely corrects for gross…

Computer Vision and Pattern Recognition · Computer Science 2021-09-02 Sergiu Mocanu , Alan R. Moody , April Khademi

Optical imaging plays a critical role in advancing our understanding of three dimensional dynamics of biological systems. Coherent imaging (CI) methods exploit spatial phase information, encoded through propagation of coherent signal light…

Optics · Physics 2015-07-24 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Spectral Domain Optical Coherence Tomography (SD-OCT) is a well-known imaging modality which allows for \textit{in-vivo} visualization of the morphology of different biological tissues at cellular level resolutions. The overall SD-OCT…

We report the design of diffractive surfaces to all-optically perform arbitrary complex-valued linear transformations between an input (N_i) and output (N_o), where N_i and N_o represent the number of pixels at the input and output…

Optics · Physics 2021-09-27 Onur Kulce , Deniz Mengu , Yair Rivenson , Aydogan Ozcan

A zero-area four-blade perfect crystal neutron interferometer (NI) possess a decoherence-free subspace (DFS) for low-frequency mechanical vibrations and thus is easier to site. %has the potential to broaden the application of crystal-based…

Quantum Physics · Physics 2019-04-17 J. Nsofini , D. Sarenac , D. G. Cory , D. A. Pushin

As the lateral resolution of FFOCT with spatially incoherent illumination has been shown to be insensitive to aberrations, we demonstrate high resolution en face full-field OCT (FFOCT) retinal imaging without wavefront correction in the…

Medical Physics · Physics 2018-04-02 Peng Xiao , Viacheslav Mazlin , Kate Grieve , Jose-Alain Sahel , Mathias Fink , A. Claude Boccara

Super-resolution fluorescence microscopy provides unprecedented insight into cellular and subcellular structures. However, going "beyond the diffraction barrier" comes at a price since most far-field super-resolution imaging techniques…

Selective plane illumination microscopy (SPIM), also known as light sheet fluorescence microscopy, provides high specificity through fluorescence labeling. However, it lacks complementary structural information from the surrounding context,…

Optics · Physics 2024-12-19 Rui Ma , Olga Lyraki , Daniel Wehner , Jochen Guck
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