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A deep convolutional neural network has been developed to denoise atomic-resolution TEM image datasets of nanoparticles acquired using direct electron counting detectors, for applications where the image signal is severely limited by shot…

Image enhancement is an important image processing technique that processes images suitably for a specific application e.g. image editing. The conventional solutions of image enhancement are grouped into two categories which are spatial…

Computer Vision and Pattern Recognition · Computer Science 2016-09-14 Hui Li , Xiaomeng Wang , Weifeng Liu , Yanjiang Wang

An efficient computational approach for optimal reconstructing parameters of binary-type physical properties for models in biomedical applications is developed and validated. The methodology includes gradient-based multiscale optimization…

Computational Physics · Physics 2020-12-24 Priscilla M. Koolman , Vladislav Bukshtynov

This report presents the comprehensive implementation, evaluation, and optimization of Denoising Diffusion Probabilistic Models (DDPMs) and Denoising Diffusion Implicit Models (DDIMs), which are state-of-the-art generative models. During…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Jaineet Shah , Michael Gromis , Rickston Pinto

Recently it has been shown that precise dose control and an increase in the overall acquisition speed of atomic resolution scanning transmission electron microscope (STEM) images can be achieved by acquiring only a small fraction of the…

Aberration-corrected Scanning Transmission Electron Microscopy (STEM) has become an essential tool in understanding materials at the atomic scale. However, tuning the aberration corrector to produce a sub-{\AA}ngstr\"om probe is a complex…

We propose an adaptive learning procedure to learn patch-based image priors for image denoising. The new algorithm, called the Expectation-Maximization (EM) adaptation, takes a generic prior learned from a generic external database and…

Computer Vision and Pattern Recognition · Computer Science 2016-08-24 Enming Luo , Stanley H. Chan , Truong Q. Nguyen

Electroencephalography (EEG) is a generally used neuroimaging approach in brain-computer interfaces due to its non-invasive characteristics and convenience, making it an effective tool for understanding human intentions. Therefore, recent…

Signal Processing · Electrical Eng. & Systems 2024-11-19 Sung-Jin Kim , Dae-Hyeok Lee , Hyeon-Taek Han

Image simulation for scanning transmission electron microscopy at atomic resolution for samples with realistic dimensions can require very large computation times using existing simulation algorithms. We present a new algorithm named PRISM…

Materials Science · Physics 2017-04-24 Colin Ophus

Electron cryomicroscopy (cryo-EM) is a technique in structural biology used to reconstruct accurate volumetric maps of molecules. One step of the cryo-EM pipeline involves solving an inverse-problem. This inverse-problem, referred to as…

Quantitative Methods · Quantitative Biology 2024-11-26 Aaditya V. Rangan , Wai-Shing Tang , Pilar Cossio , Kexin Zhang , Nikolaus Grigorieff

Particle picking is currently a critical step in the cryo-electron microscopy single particle reconstruction pipeline. Contaminations in the acquired micrographs severely degrade the performance of particle pickers, resulting is many…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Amitay Eldar , Ido Amos , Yoel Shkolnisky

Accurate detection of quantum states is a vital step in the development of quantum computing. Image-charge detection of quantum states of electrons on liquid helium can potentially be used for the readout of a single-electron qubit;…

Quantum Physics · Physics 2021-01-12 Asem Elarabi , Erika Kawakami , Denis Konstantinov

A major challenge in single particle reconstruction from cryo-electron microscopy is to establish a reliable ab-initio three-dimensional model using two-dimensional projection images with unknown orientations. Common-lines based methods…

Machine Learning · Computer Science 2013-04-11 Lanhui Wang , Amit Singer , Zaiwen Wen

Cryogenic electron microscopy (Cryo-EM) has become an essential tool for capturing high-resolution biological structures. Despite its advantage in visualizations, the large storage size of Cryo-EM data file poses significant challenges for…

Machine Learning · Computer Science 2025-12-16 Chunyu Zou

The recent improvements in cryo-electron microscopy (cryo-EM) in the past few years are now allowing to observe molecular complexes at atomic resolution. As a consequence, numerous structures derived from cryo-EM are now available in the…

Biomolecules · Quantitative Biology 2020-05-04 Mikael Trellet , Gydo van Zundert , Alexandre M. J. J. Bonvin

High-sensitivity imaging of ultracold atoms is often challenging when interference patterns are imprinted on the imaging light. Such image noises result in low signal-to-noise ratio and limit the capability to extract subtle physical…

Quantum Gases · Physics 2020-09-09 Bo Song , Chengdong He , Zejian Ren , Entong Zhao , Jeongwon Lee , Gyu-Boong Jo

The maximum entropy method (MEM) is a well known deconvolution technique in radio-interferometry. This method solves a non-linear optimization problem with an entropy regularization term. Other heuristics such as CLEAN are faster but highly…

Instrumentation and Methods for Astrophysics · Physics 2022-10-27 M. Cárcamo , P. Román , S. Casassus , V. Moral , F. R. Rannou

The usage of digital content (photos and videos) in a variety of applications has increased due to the popularity of multimedia devices. These uses include advertising campaigns, educational resources, and social networking platforms. There…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Muhammad Turab

Electron cryo-tomography (cryo-ET) enables 3D imaging of complex, radiation-sensitive structures with molecular detail. However, image contrast from the interference of scattered electrons is nonlinear with atomic density and multiple…

An efficient computational approach for optimal reconstruction of binary-type images suitable for models in various applications including biomedical imaging is developed and validated. The methodology includes derivative-free optimization…

Optimization and Control · Mathematics 2022-09-27 Paul R. Arbic , Vladislav Bukshtynov