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Related papers: FiltPIM: In-Memory Filter for DNA Sequencing

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Mixed-Integer Linear Programming (MILP) is a foundational tool for complex decision-making problems. However, the NP-hard nature of MILP presents a significant computational challenge, motivating the development of machine learning-based…

Optimization and Control · Mathematics 2026-03-03 Hongpei Li , Hui Yuan , Han Zhang , Jianghao Lin , Dongdong Ge , Mengdi Wang , Yinyu Ye

Automatic detection of brain neoplasm in Magnetic Resonance Imaging (MRI) is gaining importance in many medical diagnostic applications. This report presents two improvements for brain neoplasm detection in MRI data: an advanced…

Computer Vision and Pattern Recognition · Computer Science 2021-01-26 Nilanjan Sinhababu , Monalisa Sarma , Debasis Samanta

With growing investigations into solving partial differential equations by physics-informed neural networks (PINNs), more accurate and efficient PINNs are required to meet the practical demands of scientific computing. One bottleneck of…

Machine Learning · Computer Science 2025-10-29 Tianchi Yu , Yiming Qi , Ivan Oseledets , Shiyi Chen

When analyzing communities of microorganisms from their sequenced DNA, an important task is taxonomic profiling: enumerating the presence and relative abundance of all organisms, or merely of all taxa, contained in the sample. This task can…

Genomics · Quantitative Biology 2020-01-24 Simon Foucart , David Koslicki

Von Neumann architecture based computers isolate/physically separate computation and storage units i.e. data is shuttled between computation unit (processor) and memory unit to realize logic/ arithmetic and storage functions. This…

Emerging Technologies · Computer Science 2020-02-17 Sandeep Kaur Kingra , Vivek Parmar , Che-Chia Chang , Boris Hudec , Tuo-Hung Hou , Manan Suri

The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-27 Bertil Schmidt , Felix Kallenborn , Alexander Wichmann , Alejandro Chacon , Christian Hundt

Electroencephalography (EEG) and local field potentials (LFP) are two widely used techniques to record electrical activity from the brain. These signals are used in both the clinical and research domains for multiple applications. However,…

Machine Learning · Computer Science 2026-01-22 Manuel A. Hernandez Alonso , Michael Depass , Stephan Quessy , Ali Falaki , Soraya Rahimi , Numa Dancause , Ignasi Cos

Bloom Filter is a probabilistic data structure for the membership query, and it has been intensely experimented in various fields to reduce memory consumption and enhance a system's performance. Bloom Filter is classified into two key…

Data Structures and Algorithms · Computer Science 2021-06-09 Sabuzima Nayak , Ripon Patgiri

Designing protein sequences that fold into a target 3-D structure, termed as the inverse folding problem, is central to protein engineering. However, it remains challenging due to the vast sequence space and the importance of local…

Quantitative Methods · Quantitative Biology 2026-03-17 Sazan Mahbub , Souvik Kundu , Eric P. Xing

Memristive Processing In-Memory (PIM) is one of the promising techniques for overcoming the Von-Neumann bottleneck. Reduction of data transfer between processor and memory and data processing by memristors in data-intensive applications…

Emerging Technologies · Computer Science 2024-10-15 Seyed Erfan Fatemieh , Bahareh Bagheralmoosavi , Mohammad Reza Reshadinezhad

To build the connectomics map of the brain, we developed a new algorithm that can automatically refine the Membrane Detection Probability Maps (MDPM) generated to perform automatic segmentation of electron microscopy (EM) images. To achieve…

Neural and Evolutionary Computing · Computer Science 2015-06-22 Xundong Wu

Modern Artificial Intelligence (AI) applications are increasingly utilizing multi-tenant deep neural networks (DNNs), which lead to a significant rise in computing complexity and the need for computing parallelism. ReRAM-based…

Emerging Technologies · Computer Science 2024-08-12 Bojing Li , Duo Zhong , Xiang Chen , Chenchen Liu

While general-purpose computing follows Von Neumann's architecture, the data movement between memory and processor elements dictates the processor's performance. The evolving compute-in-memory (CiM) paradigm tackles this issue by…

Hardware Architecture · Computer Science 2024-11-15 Dhandeep Challagundla , Ignatius Bezzam , Riadul Islam

This paper aims to present a new re-configuration sequencing method for difference of read lengths that may take place as input data in which is crucial drawbacks lay impact on DNA sequencing methods.

Hardware Architecture · Computer Science 2020-09-22 Mahdi Taheri , Hamed Zandevakili , Ali Mahani

Mass spectrometry (MS) is essential for proteomics and metabolomics but faces impending challenges in efficiently processing the vast volumes of data. This paper introduces SpecPCM, an in-memory computing (IMC) accelerator designed to…

Hardware Architecture · Computer Science 2024-11-18 Keming Fan , Ashkan Moradifirouzabadi , Xiangjin Wu , Zheyu Li , Flavio Ponzina , Anton Persson , Eric Pop , Tajana Rosing , Mingu Kang

Due to the very rapidly growing use of Artificial Neural Networks (ANNs) in real-world applications related to machine learning and Artificial Intelligence (AI), several hardware accelerator de-signs for ANNs have been proposed recently. In…

Hardware Architecture · Computer Science 2021-03-09 Supreeth Mysore Shivanandamurthy , Ishan. G. Thakkar , Sayed Ahmad Salehi

To address the increasing computational demands of artificial intelligence (AI) and big data, compute-in-memory (CIM) integrates memory and processing units into the same physical location, reducing the time and energy overhead of the…

Emerging Technologies · Computer Science 2023-09-19 Xiwen Liu , Keshava Katti , Yunfei He , Paul Jacob , Claudia Richter , Uwe Schroeder , Santosh Kurinec , Pratik Chaudhari , Deep Jariwala

Edge deployment of low-batch large language models (LLMs) faces critical memory bandwidth bottlenecks when executing memory-intensive general matrix-vector multiplications (GEMV) operations. While digital processing-in-memory (PIM)…

Hardware Architecture · Computer Science 2026-01-21 Ye Lin , Chao Fang , Xiaoyong Song , Qi Wu , Anying Jiang , Yichuan Bai , Li Du

Compute-In-Memory (CIM) systems, particularly those utilizing ReRAM and memristive technologies, offer a promising path toward energy-efficient neural network computation. However, conventional quantization and compression techniques often…

Hardware Architecture · Computer Science 2025-12-23 Guan-Cheng Chen , Chieh-Lin Tsai , Pei-Hsuan Tsai , Yuan-Hao Chang

Many approaches to program synthesis perform a search within an enormous space of programs to find one that satisfies a given specification. Prior works have used neural models to guide combinatorial search algorithms, but such approaches…

Machine Learning · Computer Science 2023-10-31 Kensen Shi , Hanjun Dai , Kevin Ellis , Charles Sutton