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This paper deals with a general system of equations and conditions arising from a mathematical model of prostate cancer growth with chemotherapy and antiangiogenic therapy that has been recently introduced and analyzed (see [P. Colli et…

Analysis of PDEs · Mathematics 2021-04-02 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

Motivated by the incompressible limit of a cell density model, we propose a free boundary tumor growth model where the pressure satisfies an obstacle problem on an evolving domain $\Omega(t)$, and the coincidence set $\Lambda(t)$ captures…

Analysis of PDEs · Mathematics 2023-11-01 Xu'an Dou , Chengfeng Shen , Zhennan Zhou

In this work we study the degenerate diffusion equation $\partial_{t}=x^{\alpha}a\left(x\right)\partial_{x}^{2}+b\left(x\right)\partial_{x}$ for $\left(x,t\right)\in\left(0,\infty\right)^{2}$, equipped with a Cauchy initial data and the…

Analysis of PDEs · Mathematics 2020-09-01 Linan Chen , Ian Weih-Wadman

Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the…

Tissues and Organs · Quantitative Biology 2015-01-05 Arianna Bianchi , Kevin J. Painter , Jonathan A. Sherratt

A novel numerical technique has been proposed to solve a two-phase tumour growth model in one spatial dimension without needing to account for the boundary dynamics explicitly. The equivalence to the standard definition of a weak solution…

Numerical Analysis · Mathematics 2019-02-19 Gopikrishnan C. Remesan

This paper is devoted to the study of initial-boundary value problems for time-fractional analogues of Korteweg-de Vries, Benjamin-Bona-Mahony, Burgers, Rosenau, Camassa-Holm, Degasperis-Procesi, Ostrovsky and time-fractional modified…

Analysis of PDEs · Mathematics 2021-10-05 Bashir Ahmad , Ahmed Alsaedi , Mokhtar Kirane , Berikbol T. Torebek

When modeling of tumor-driven angiogenesis, a major source of analytical and computational complexity is the strong coupling between the kinetic parameters of the relevant stochastic branching-and-growth of the capillary network, and the…

Tissues and Organs · Quantitative Biology 2014-12-24 L. L. Bonilla , V. Capasso , M. Alvaro , M. Carretero

We consider here a model of accelerating fronts, introduced in [2], consisting of one equation with nonlocal diffusion on a line, coupled via the boundary condition with a reaction-diffusion equation of the Fisher-KPP type in the upper…

Analysis of PDEs · Mathematics 2019-11-11 Anne-Charline Chalmin , Jean-Michel Roquejoffre

We present a problem-suited numerical method for a particularly challenging cancer invasion model. This model is a multiscale haptotaxis advection-reaction-diffusion system that describes the macroscopic dynamics of two types of cancer…

Numerical Analysis · Mathematics 2016-05-18 Niklas Kolbe , Maria Lukacova-Medvidova , Nikolaos Sfakianakis , Bettina Wiebe

The main target of this paper is to present an efficient method to solve a nonlinear free boundary mathematical model of prostate tumor. This model consists of two parabolics, one elliptic and one ordinary differential equations that are…

Numerical Analysis · Mathematics 2022-03-31 Farzaneh Nasresfahani , M. R. Eslahchi

During the last decades, medical observations and multiscale data concerning tumor growth are mounting. At the same time, contemporary imaging techniques well established in clinical practice, provide a variety of information on real-time,…

Tissues and Organs · Quantitative Biology 2017-12-11 Markos Antonopoulos , Georgios Stamatakos

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

Analysis of PDEs · Mathematics 2014-12-05 Sergio Frigeri , Maurizio Grasselli , Elisabetta Rocca

Comparing mathematical models offers a means to evaluate competing scientific theories. However, exact methods of model calibration are not applicable to many probabilistic models which simulate high-dimensional spatio-temporal data.…

Quantitative Methods · Quantitative Biology 2026-01-13 Robert A McDonald , Helen M Byrne , Heather A Harrington , Thomas Thorne , Bernadette J Stolz

Tumor induced angiogenesis processes including the effect of stochastic motion and branching of blood vessels can be described coupling a (nonlocal in time) integrodifferential kinetic equation of Fokker-Planck type with a diffusion…

Analysis of PDEs · Mathematics 2016-12-30 Ana Carpio , Gema Duro

This paper is devoted to the analysis of a mathematical model of blood cells production in the bone marrow (hematopoiesis). The model is a system of two age-structured partial differential equations. Integrating these equations over the…

Analysis of PDEs · Mathematics 2009-04-17 Mostafa Adimy , Fabien Crauste , Shigui Ruan

Following our recent letter, we study in detail an entry-wise diffusion of non-hermitian complex matrices. We obtain an exact partial differential equation (valid for any matrix size $N$ and arbitrary initial conditions) for evolution of…

Mathematical Physics · Physics 2015-10-20 Zdzislaw Burda , Jacek Grela , Maciej A. Nowak , Wojciech Tarnowski , Piotr Warchoł

In this paper we study a convection-diffusion equation on a star-shaped graph composed by $n$ incoming edges and $m$ outgoing edges with a nonlinearity $f\in C^1(\rr)$ satisfying some additional general conditions. First, we prove the…

Analysis of PDEs · Mathematics 2022-01-11 Cristian M. Cazacu , Liviu I. Ignat , Ademir F. Pazoto , Julio D. Rossi

A nutrient-limited model for avascular cancer growth including cell proliferation, motility and death is presented. The model qualitatively reproduces commonly observed morphologies for primary tumors, and the simulated patterns are…

Statistical Mechanics · Physics 2011-03-09 S. C. Ferreira Junior , M. L. Martins , M. J. Vilela

We investigate avascular tumour growth as a two-phase process consisting of cells and liquid. Based on the one-dimensional continuum moving-boundary model formulated by (Byrne, King, McElwain, Preziosi, Applied Mathematics Letters, 2003,…

Analysis of PDEs · Mathematics 2020-06-24 Andrea Genovese de Oliveira , John R. King

In this work, we consider an inverse problem of determining a time dependent coefficient in a fully fractional diffusion equation with a nonlinear source term. The nonlocal initial-boundary value problem refers to the forward model: the…

Analysis of PDEs · Mathematics 2025-12-10 D. K. Durdiev , H. H. Turdiev