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We propose a model for glioma patterns in a microlocal tumor environment under the influence of acidity, angiogenesis, and tissue anisotropy. The bottom-up model deduction eventually leads to a system of reaction-diffusion-taxis equations…

Tissues and Organs · Quantitative Biology 2020-09-22 Pawan Kumar , Christina Surulescu

Mathematical modelling of tumor growth is one of the most useful and inexpensive approaches to determine and predict the stage, size and progression of tumors in realistic geometries. Moreover, these models has been used to get an insight…

Medical Physics · Physics 2017-08-01 Miguel Martín-Landrove

Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the…

Populations and Evolution · Quantitative Biology 2010-11-18 Ivana Bozic , Tibor Antal , Hisashi Ohtsuki , Hannah Carter , Dewey Kim , Sining Chen , Rachel Karchin , Kenneth W. Kinzler , Bert Vogelstein , Martin A. Nowak

The Moyal *-deformed noncommutative version of Burgers' equation is considered. Using the *-analog of the Cole-Hopf transformation, the linearization of the model in terms of the linear heat equation is found. Noncommutative q-deformations…

High Energy Physics - Theory · Physics 2007-05-23 L. Martina , O. K. Pashaev

We prove sharp estimates for the decay in time of solutions to a rather general class of non-local in time subdiffusion equations on a bounded domain subject to a homogeneous Dirichlet boundary condition. Important special cases are the…

Analysis of PDEs · Mathematics 2013-10-02 Vicente Vergara , Rico Zacher

Differential equations with convective terms such as the Burger's equation appear in many applications and have been the subject of intense research. In this paper we use a generalized form of Cole-Hopf transformation to relate the…

Mathematical Physics · Physics 2013-08-06 Mayer Humi

This article considers a limit system by passing to the limit in the following Cahn--Hilliard type phase field system related to tumor growth as $\beta\searrow0$: \begin{equation*} \begin{cases} \alpha\partial_{t} \mu_{\beta} + \partial_{t}…

Analysis of PDEs · Mathematics 2019-05-01 Shunsuke Kurima

Existing approaches to modeling the dynamics of brain tumor growth, specifically glioma, employ biologically inspired models of cell diffusion, using image data to estimate the associated parameters. In this work, we propose an alternative…

Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in the development of mathematical models capable of capturing…

Populations and Evolution · Quantitative Biology 2025-04-10 Chiara Villa , Philip K Maini , Alexander P Browning , Adrianne L Jenner , Sara Hamis , Tyler Cassidy

We consider a free boundary tumor model under the presence of angiogenesis and time delays in the process of proliferation, in which the cell location is incorporated. It is assumed that the tumor attracts blood vessels at a rate…

Analysis of PDEs · Mathematics 2021-03-09 Zejia Wang , Haihua Zhou , Huijuan Song

We consider an evolution equation generalising the viscous Burgers equation supplemented by an initial condition which is a homogeneous random field. We develop a non-linear framework enabling us to show the existence and regularity of…

Analysis of PDEs · Mathematics 2018-10-29 Miłosz Krupski

The time evolution of spatial fluctuations in inhomogeneous d-dimensional biological systems is analyzed. A single species continuous growth model, in which the population disperses via diffusion and convection is considered.…

Disordered Systems and Neural Networks · Physics 2009-10-30 David R. Nelson , Nadav M. Shnerb

Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behaviour, at least…

Dynamical Systems · Mathematics 2014-11-25 V. Castillo , J. Tomas Lazaro , J. Sardanyes

In the field of modeling the dynamics of oncolytic viruses, researchers often face the challenge of using specialized mathematical terms to explain uncertain biological phenomena. This paper introduces a basic framework for an oncolytic…

Dynamical Systems · Mathematics 2024-02-22 Zizi Wang

We explore the noiseless Burgers dynamics in the inviscid limit, the so-called ``adhesion model'' in cosmology, in a regime where (almost) all the fluid particles are embedded within point-like massive halos. Following previous works, we…

Cosmology and Nongalactic Astrophysics · Physics 2014-11-20 Francis Bernardeau , Patrick Valageas

In this paper we present a method for estimating unknown parameter that appear in a two dimensional nonlinear reaction-diffusion model of cancer invasion. This model considers that tumor-induced alteration of microenvironmental pH provides…

Optimization and Control · Mathematics 2014-05-21 A. A. I. Quiroga , D. R. Fernandez , G. A. Torres , C. V. Turner

We derive a Cahn-Hilliard-Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a…

Analysis of PDEs · Mathematics 2019-11-01 Harald Garcke , Kei Fong Lam , Robert Nürnberg , Emanuel Sitka

In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…

Analysis of PDEs · Mathematics 2021-08-31 Xu'an Dou , Jian-Guo Liu , Zhennan Zhou

We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $\varphi_p$, $\varphi_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The…

Analysis of PDEs · Mathematics 2017-09-06 Sergio Frigeri , Kei Fong Lam , Elisabetta Rocca , Giulio Schimperna

In this paper we present a method for estimating unknown parameters that appear on an avascular, spheric tumour growth model. The model for the tumour is based on nutrient driven growth of a continuum of live cells, whose birth and death…

Mathematical Physics · Physics 2012-09-14 D. A. Knopoff , D. R. Fernández , G. A. Torres , C. V. Turner
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