English

On a diffuse interface model of tumor growth

Analysis of PDEs 2014-12-05 v2

Abstract

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction φ\varphi nonlinearly coupled with a reaction-diffusion equation for ψ\psi, which represents the nutrient-rich extracellular water volume fraction. The coupling is expressed through a suitable proliferation function p(φ)p(\varphi) multiplied by the differences of the chemical potentials for φ\varphi and ψ\psi. The system is equipped with no-flux boundary conditions which entails the conservation of the total mass, that is, the spatial average of φ+ψ\varphi+\psi. Here we prove the existence of a weak solution to the associated Cauchy problem, provided that the potential FF and pp satisfy sufficiently general conditions. Then we show that the weak solution is unique and continuously depends on the initial data, provided that pp satisfies slightly stronger growth restrictions. Also, we demonstrate the existence of a strong solution and that any weak solution regularizes in finite time. Finally, we prove the existence of the global attractor in a phase space characterized by an a priori bounded energy.

Keywords

Cite

@article{arxiv.1405.3446,
  title  = {On a diffuse interface model of tumor growth},
  author = {Sergio Frigeri and Maurizio Grasselli and Elisabetta Rocca},
  journal= {arXiv preprint arXiv:1405.3446},
  year   = {2014}
}

Comments

31 pages

R2 v1 2026-06-22T04:13:50.154Z