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The novel coronavirus (SARS-CoV-2) has led to a pandemic. The current testing regime based on Reverse Transcription-Polymerase Chain Reaction for SARS-CoV-2 has been unable to keep up with testing demands, and also suffers from a relatively…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing pandemic infecting 219 million people as of 10/19/21, with a 3.6% mortality rate. Natural selection can generate favorable mutations with improved fitness…

Quantitative Methods · Quantitative Biology 2021-11-04 Yingying Wu , Shusheng Xu , Shing-Tung Yau , Yi Wu

While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication…

Recent outbreaks of infectious diseases have been monitored closely from an epidemiological and microbiological perspective. Extracting from this wealth of data the information that is relevant for the evolution of the pathogen and predict…

Populations and Evolution · Quantitative Biology 2024-10-10 Baptiste Filoche , Stefan Hohenegger

Identifying mutations of SARS-CoV-2 strains associated with their phenotypic changes is critical for pandemic prediction and prevention. We compared an explainable convolutional neural network (CNN) approach and the traditional genome-wide…

Genomics · Quantitative Biology 2025-01-03 Parisa Hatami , Richard Annan , Luis Urias Miranda , Jane Gorman , Mengjun Xie , Letu Qingge , Hong Qin

SARS-CoV-2 is a new human coronavirus (CoV), which emerged in China in late 2019 and is responsible for the global COVID-19 pandemic that caused more than 59 million infections and 1.4 million deaths in 11 months. Understanding the origin…

Populations and Evolution · Quantitative Biology 2020-11-26 Erwan Sallard , José Halloy , Didier Casane , Etienne Decroly , Jacques van Helden

We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and general procedure, based on the representation of the molecular…

The COVID-19 pandemic has been a great catastrophe that upended human lives and caused millions of deaths all over the world. The rapid spread of the virus, with its early-stage exponential growth and subsequent 'waves', caught many medical…

Populations and Evolution · Quantitative Biology 2022-05-31 Anne V. Ginzburg , Valeriy V. Ginzburg , Julia O. Ginzburg , Ana Garcia Arias , Leela Rakesh

CovID-19 genetics analysis is critical to determine virus type,virus variant and evaluate vaccines. In this paper, SARS-Cov-2 RNA sequence analysis relative to region or territory is investigated. A uniform framework of sequence SVM model…

Quantitative Methods · Quantitative Biology 2021-01-12 Jingwei Liu

To support the ongoing management of viral respiratory diseases, many countries are moving towards an integrated model of surveillance for SARS-CoV-2, influenza, and other respiratory pathogens. While many surveillance approaches catalysed…

The current SARS-CoV-2 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this snapshot, our aim is to provide a…

Other Quantitative Biology · Quantitative Biology 2020-04-01 Yinon M. Bar-On , Avi I. Flamholz , Rob Phillips , Ron Milo

The mechanism of SARS-CoV-2 evolution and transmission is elusive and its understanding, a prerequisite to forecast emerging variants, is of paramount importance. SARS-CoV-2 evolution is driven by the mechanisms at molecular and organism…

Populations and Evolution · Quantitative Biology 2021-09-20 Jiahui Chen , Rui Wang , Guo-Wei Wei

We propose a Markovian stochastic approach to model the spread of a SARS-CoV-2-like infection within a closed group of humans. The model takes the form of a Partially Observable Markov Decision Process (POMDP), whose states are given by the…

Systems and Control · Electrical Eng. & Systems 2022-04-26 Luigi Palopoli , Daniele Fontanelli , Marco Frego , Marco Roveri

Covid-19 infection, which spread to the whole world in December 2019 and is still active, caused more than 250 thousand deaths in the world today. Researches on this subject have been focused on analyzing the genetic structure of the virus,…

Machine Learning · Computer Science 2023-04-25 Selcuk Yazar

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the importance and challenges of correctly interpreting antibody test results. Identification of positive and negative samples requires a…

Quantitative Methods · Quantitative Biology 2023-04-26 Rayanne A. Luke , Anthony J. Kearsley , Nora Pisanic , Yukari C. Manabe , David L. Thomas , Christopher D. Heaney , Paul N. Patrone

The rapid spreading of SARS-CoV-2 and its dramatic consequences, are forcing policymakers to take strict measures in order to keep the population safe. At the same time, societal and economical interactions are to be safeguarded. A wide…

Disordered Systems and Neural Networks · Physics 2021-02-17 Lorenzo Chicchi , Lorenzo Giambagli , Lorenzo Buffoni , Duccio Fanelli

The pandemic of COVID-19 has imposed tremendous pressure on public health systems and social economic ecosystems over the past years. To alleviate its social impact, it is important to proactively track the prevalence of COVID-19 within…

In this work, we derive a system of Boltzmann-type equations to describe the spread of SARS-CoV-2 virus at the microscopic scale, that is by modeling the human-to-human mechanisms of transmission. To this end, we consider two populations,…

Populations and Evolution · Quantitative Biology 2024-02-09 Marzia Bisi , Silvia Lorenzani

With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

Genomics · Quantitative Biology 2021-11-16 Sarwan Ali , Murray Patterson

How may exposure risks to SARS-CoV-2 be assessed quantitatively? The material metabolism approach of Industrial Ecology can be applied to the mass flows of these virions by their numbers, as a key step in the analysis of the current…

Quantitative Methods · Quantitative Biology 2020-10-30 Gjalt Huppes , Ruben Huele
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