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A central pillar of the UK's response to the SARS-CoV-2 pandemic was the provision of up-to-the moment nowcasts and short term projections to monitor current trends in transmission and associated healthcare burden. Here we present a…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical presentation that ranges from asymptomatic, to severe disease with cytokine storm. The mortality rates also differ across the globe, ranging from 0.5-13%.…

As the year 2020 draws to an end, several new strains have been reported for the SARS-CoV-2 coronavirus, the agent responsible for the COVID-19 pandemic that has afflicted us all this past year. However, it is difficult to comprehend the…

Genomics · Quantitative Biology 2023-06-09 Rene L. Warren , Inanc Birol

The COVID-19 pandemic is spreading rapidly around the world, causing countries to impose lockdowns and efforts to develop vaccines on a global scale. However, human-to-animal and animal-to-human transmission cannot be ignored, as severe…

Populations and Evolution · Quantitative Biology 2024-08-20 Zi Hian Tan , Kian Yan Yong , Jian-Jun Shu

With recent advances in sequencing technology it has become affordable and practical to sequence genomes to very high depth-of-coverage, allowing researchers to discover low-frequency variants in the genome. However, due to the errors in…

Genomics · Quantitative Biology 2021-05-10 Bryce Kille , Yunxi Liu , Nicolae Sapoval , Michael Nute , Lawrence Rauchwerger , Nancy Amato , Todd J. Treangen

Accurate modeling of lockdown effects on SARS-CoV-2 epidemic evolution is a key issue in order e.g. to inform health-care decisions on emergency management. The compartmental and spatial models so far proposed use parametric descriptions of…

Systems and Control · Electrical Eng. & Systems 2020-08-31 Gianluigi Pillonetto , Mauro Bisiacco , Giorgio Palù , Claudio Cobelli

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening. However, rigorous determination of SARS-COV-2 infectivity is essentially…

Biomolecules · Quantitative Biology 2020-06-01 Jiahui Chen , Rui Wang , Menglun Wang , Guo-Wei Wei

SARS-CoV-2 lineages are defined according to placement in a phylogenetic tree, but approximated by a list of mutations based on sequences collected from clinical sampling. Wastewater lineage abundance is generally found under the assumption…

Methodology · Statistics 2025-08-06 Devan Becker

The SARS-CoV-2 pandemic has led to a significant emergence of highly mutated forms of viruses with a great ability to adapt to the human host. Some mutations resulted in changes in the amino acid sequences of viral proteins, including the…

Faced with the 2020 SARS-CoV2 epidemic, public health officials have been seeking models that could be used to predict not only the number of new cases but also the levels of hospitalisation, critical care and deaths. In this paper we…

Populations and Evolution · Quantitative Biology 2020-12-24 Jonathan Wells , Chris Robertson , Vincent Marmara , Alan Yeung , Adam Kleczkowski

In the case of SARS-CoV-2 pandemic management, wastewater-based epidemiology aims to derive information on the infection dynamics by monitoring virus concentrations in the wastewater. However, due to the intrinsic random fluctuations of the…

The importance of the working document is that it allows the analysis of information and cases associated with (SARS-CoV-2) COVID-19, based on the daily information generated by the Government of Mexico through the Secretariat of Health,…

Computers and Society · Computer Science 2021-12-03 Medel-Ramírez Carlos , Medel-López Hilario , Lara-Mérida Jennifer

In this paper, we estimate the seroprevalence against COVID-19 by country and derive the seroprevalence over the world. To estimate seroprevalence, we use serological surveys (also called the serosurveys) conducted within each country. When…

Applications · Statistics 2022-02-01 Kwangmin Lee , Seongmin Kim , Seongil Jo , Jaeyong Lee

The rapid spread of the COVID-19 pandemic has resulted in an unprecedented amount of sequence data of the SARS-CoV-2 genome -- millions of sequences and counting. This amount of data, while being orders of magnitude beyond the capacity of…

Genomics · Quantitative Biology 2022-07-20 Sarwan Ali , Bikram Sahoo , Alexander Zelikovskiy , Pin-Yu Chen , Murray Patterson

The identification of the transmission parameters of a virus is fundamental to identify the optimal public health strategy. These parameters can present significant changes over time caused by genetic mutations or viral recombination,…

Populations and Evolution · Quantitative Biology 2022-07-21 Eugenio Lippiello , Giuseppe Petrillo , Lucilla de Arcangelis

The spread of COVID-19 makes it essential to investigate its prevalence. In such investigation research, as far as we know, the widely-used sampling methods didn't use the information sufficiently about the numbers of the previously…

Applications · Statistics 2022-01-04 Ze Liu , Siyu Yi , Jianghu , Dong , Min-Qian Liu , Yongdao Zhou

This paper presents a critical analysis of the literature and perspective research ideas for modeling the epidemics caused by the SARS-CoV-2 virus. It goes beyond deterministic population dynamics to consider several key complexity features…

Populations and Evolution · Quantitative Biology 2025-01-24 Giulia Bertaglia , Andrea Bondesan , Diletta Burini , Raluca Eftimie , Lorenzo Pareschi , Giuseppe Toscani

The pandemic linked to COVID-19 infection represents an unprecedented clinical and healthcare challenge for many medical researchers attempting to prevent its worldwide spread. This pandemic also represents a major challenge for…

The determination of the infection fatality rate (IFR) for the novel SARS-CoV-2 coronavirus is a key aim for many of the field studies that are currently being undertaken in response to the pandemic. The IFR together with the basic…

In this worldwide spread of SARS-CoV-2 (COVID-19) infection, it is of utmost importance to detect the disease at an early stage especially in the hot spots of this epidemic. There are more than 110 Million infected cases on the globe,…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Sohail Iqbal , H. Fareed Ahmed , Talha Qaiser , Muhammad Imran Qureshi , Nasir Rajpoot