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Photoacoustic microscopy with large depth of focus is significant to the biomedical research. The conventional optical-resolution photoacoustic microscope (OR-PAM) suffers from limited depth of field (DoF) since the employed focused…

Image and Video Processing · Electrical Eng. & Systems 2020-09-07 Xianlin Song , Jianshuang Wei , Lingfang Song

In an inhomogeneously illuminated photoacoustic image, important information like vascular geometry is not readily available when only the initial pressure is reconstructed. To obtain the desired information, algorithms for image…

Image and Video Processing · Electrical Eng. & Systems 2019-06-19 Yoeri E. Boink , Srirang Manohar , Christoph Brune

Photoacoustic(PA) imaging is a non-destructive and non-invasive technology for visualizing minute blood vessel structures in the body using ultrasonic sensors. In PA imaging, the image quality of a single-shot image is poor, and it is…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Tatsuhiro Eguchi , Shumpei Takezaki , Mihoko Shimano , Takayuki Yagi , Ryoma Bise

Two-photon photoacoustic tomography (TP-PAT) is a non-invasive optical molecular imaging modality that aims at inferring two-photon absorption property of heterogeneous media from photoacoustic measurements. In this work, we analyze an…

Analysis of PDEs · Mathematics 2017-05-01 Kui Ren , Rongting Zhang

Anatomical segmentation of organs in ultrasound images is essential to many clinical applications, particularly for diagnosis and monitoring. Existing deep neural networks require a large amount of labeled data for training in order to…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Yordanka Velikova , Mohammad Farid Azampour , Walter Simson , Vanessa Gonzalez Duque , Nassir Navab

Significance: Optical imaging of blood oxygenation (sO$_2$) can be achieved based on the differential absorption spectra of oxy- and deoxy-haemoglobin. A key challenge in realising clinical validation of the sO$_2$ biomarkers is the absence…

Synthetic PET images are valuable for quantitative imaging workflow development, scalable virtual imaging trials, and deep learning model training, but conventional physics-based simulation approaches are computationally intensive, limited…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Suya Li , Kaushik Dutta , Debojyoti Pal , Jingqin Luo , Kooresh I. Shoghi

3D photoacoustic tomography (3D-PAT) using high-frequency hemispherical transducers offers near-omnidirectional reception and enhanced sensitivity to the finer structural details encoded in the high-frequency components of the broadband…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 I Gede Eka Sulistyawan , Takuro Ishii , Riku Suzuki , Yoshifumi Saijo

Photoacoustic tomography (PAT) is a promising imaging technique that can visualize the distribution of chromophores within biological tissue. However, the accuracy of PAT imaging is compromised by light fluence (LF), which hinders the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-11 Zhaoyong Liang , Shuangyang Zhang , Zhichao Liang , Zhongxin Mo , Xiaoming Zhang , Yutian Zhong , Wufan Chen , Li Qi

Estimation of blood oxygenation with spectroscopic photoacoustic imaging is a promising tool for several biomedical applications. For this method to be quantitative, it relies on an accurate method of the light fluence in the tissue. This…

Image and Video Processing · Electrical Eng. & Systems 2019-11-06 Geoffrey P. Luke , Kevin Hoffer-Hawlik , Austin C. Van Namen , Ruibo Shang

Photoacoustic microscopy is becoming an important tool for the biomedical research. It has been widely used in biological researches, such as structural imaging of vasculature, brain structural and functional imaging, and tumor detection.…

Image and Video Processing · Electrical Eng. & Systems 2020-09-09 Xianlin Song , Jianshuang Wei , Lingfang Song

Ultrasound (US) imaging is widely used for biometric measurement and diagnosis of internal organs due to the advantages of being real-time and radiation-free. However, due to inter-operator variations, resulting images highly depend on the…

Robotics · Computer Science 2023-11-30 Zhongliang Jiang , Yuan Bi , Mingchuan Zhou , Ying Hu , Michael Burke , Nassir Navab

We introduce DeepNAT, a 3D Deep convolutional neural network for the automatic segmentation of NeuroAnaTomy in T1-weighted magnetic resonance images. DeepNAT is an end-to-end learning-based approach to brain segmentation that jointly learns…

Computer Vision and Pattern Recognition · Computer Science 2017-02-28 Christian Wachinger , Martin Reuter , Tassilo Klein

Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e.,…

Image and Video Processing · Electrical Eng. & Systems 2021-04-09 Tri Vu , Anthony DiSpirito , Daiwei Li , Zixuan Zhang , Xiaoyi Zhu , Maomao Chen , Laiming Jiang , Dong Zhang , Jianwen Luo , Yu Shrike Zhang , Qifa Zhou , Roarke Horstmeyer , Junjie Yao

Deep learning-based reconstruction of positron emission tomography(PET) data has gained increasing attention in recent years. While these methods achieve fast reconstruction,concerns remain regarding quantitative accuracy and the presence…

We study the mathematical model of thermoacoustic and photoacoustic tomography when the sound speed has a jump across a smooth surface. This models the change of the sound speed in the skull when trying to image the human brain. We derive…

Analysis of PDEs · Mathematics 2015-05-19 Plamen Stefanov , Gunther Uhlmann

Photoacoustic imaging (PAI) is an emerging biomedical imaging modality capable of providing both high contrast and high resolution of optical and UltraSound (US) imaging. When a short duration laser pulse illuminates the tissue as a target…

Signal Processing · Electrical Eng. & Systems 2018-01-19 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji

Photoacoustic imaging (PAI) is a novel modality in biomedical imaging technology that combines the rich optical contrast with the deep penetration of ultrasound. To date, PAI technology has found applications in various biomedical fields.…

Medical Physics · Physics 2023-09-07 Daohuai Jiang , Luyao Zhu , Shangqing Tong , Yuting Shen , Feng Gao , Fei Gao

Background: A universal unanswered question in neuroscience and machine learning is whether computers can decode the patterns of the human brain. Multi-Voxels Pattern Analysis (MVPA) is a critical tool for addressing this question. However,…

Machine Learning · Statistics 2017-10-06 Muhammad Yousefnezhad , Daoqiang Zhang

Iterative image reconstruction algorithms for optoacoustic tomography (OAT), also known as photoacoustic tomography, have the ability to improve image quality over analytic algorithms due to their ability to incorporate accurate models of…

Analysis of PDEs · Mathematics 2015-06-05 Kun wang , Richard Su , Alexander A. Oraevsky , Mark A. Anastasio